Navigation Links
Hydrophobic proteins: Potential biomarkers for colorectal cancer
Date:6/24/2010

Colorectal cancer, cancer of the colon and rectum, is a common cause of mortality worldwide. Statistical data showed that the number of deaths caused by colorectal cancer is increasing in both men and women. Proteins are functional components of the cell that regulate the cell's activity. Understanding the differential expression of proteins in colorectal cancer and normal tissues will lead to a better understanding of the development of the disease, furthermore, these proteins may serve as biomarkers for treatment or detection of the disease. Hydrophobic proteins play a vital role in various cellular processes, by virtue of their cellular location, and may serve as a target for drug-targeted therapy.

This study, led by Assoc. Prof. Dr. Gam Lay Harn from Universiti Sains Malaysia, Malaysia will be published on June 14, 2010 in the World Journal of Gastroenterology. By using two-dimensional gel electrophoresis (2D-PAGE), the hydrophobic proteins extracted from colorectal cancer tissues were separated according to their pI and MW, subsequently the protein profiles between cancerous and normal tissues were compared. Using this approach, the researchers identified a few differentially expressed proteins that were up-regulated in cancerous tissues. The expression of such proteins was shown to be significantly related to stage and grade of the cancer and also to gender of the patients.

Although the extraction of hydrophobic proteins from tissues poses certain challenges, a combination of protein reagents can be used successfully to extract this group of proteins. Followed by 2D-gel electrophoresis separation and mass spectrometry analysis, the identity of these proteins can be confirmed. The results obtained revealed the differentially expressed proteins between colorectal cancerous and normal tissues. These proteins may indicate the progression of colorectal carcinogenesis. Furthermore, they can potentially be used to design drug targeted therapy for the treatment of colorectal cancer.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Therapeutic potential of embryonic stem cells
2. Diabetic potential to create own insulin
3. MSU researchers discover potential genetic factor in eating disorders
4. Potential New Source of Stem Cells for Heart Repair
5. Decline in Potentially Lethal Hospital-Based Infections
6. Martek Biosciences and the National Center for Creative Aging Introduce New Brain Health Awareness Campaign, "Beautiful Minds: Finding Your Lifelong Potential"
7. Dr. Phillip Chang Introduces New Ways to Decrease Scars and Potential Complications For Breast Augmentations in Loudoun and Fairfax Virginia
8. Gene discovery potential key to cost-competitive cellulosic ethanol
9. Nanotech breath sensor detects diabetes and potentially serious complication
10. New twist on potential malaria drug target acts by trapping parasites in cells
11. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... Cortland, OH (PRWEB) , ... May 24, 2017 , ... ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, ... smiles while simultaneously improving their oral health and functionality. , Dr. Bedich ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... in which the endometrial lining of the uterus spreads into the pelvic ... experiencing painful intercourse, painful periods, pelvic pain, or irregular bleeding may have ...
(Date:5/24/2017)... Massapequa Park, NY (PRWEB) , ... May 24, ... ... today announced the practice is offering holistic pediatric dentistry options for its patients ... the context of the patient’s entire physical well being, and is one of ...
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – with ... either lifting weights for strength training and exercise or simply lifting heavy objects, advises ... “Body position is everything,” Dr. Chang says. “Improper technique in lifting anything heavy or ...
(Date:5/23/2017)... ... 2017 , ... Allegheny Health Network and the Alexis Joy ... Women’s Behavioral Health at West Penn Hospital , a unique facility that will ... pregnancy-related depression. Construction of the Center is underway with a scheduled opening in ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)...  Demonstrating its commitment to representing research- based ... Pharmaceutical Research and Manufacturers of America (PhRMA) today ... now have to meet new research and development ... join PhRMA. "By putting in place ... clear message that being a member of PhRMA ...
(Date:5/8/2017)... , May 8, 2017  Diplomat Pharmacy, Inc. (NYSE: ... Inc. ("WRB"), a health care service center company ... WRB specializes in relationship management programs for leading ... WRB will join Envoy ... support services for manufacturers, biotech firms, and other service ...
(Date:5/4/2017)... , May 4, 2017  Fortuna Fix Inc. (" Fortuna ... be the first to eliminate the need for embryonic and ... to treat neurodegenerative diseases. Fortuna announced ... Professor Michael Fehlings , MD, PhD; Father Kevin ... MD, MPH; and Professor James Giordano , PhD. ...
Breaking Medicine Technology: