Navigation Links
Hybrid vaccine demonstrates potential to prevent breast cancer recurrence
Date:5/17/2012

CHICAGO A breast cancer vaccine already shown to elicit a powerful immune response in women with varying levels of HER2 expression has the ability to improve recurrence rates and is well tolerated in an adjuvant setting, according to new research from a clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

The findings, released today, will be presented on Monday, June 4 in an oral presentation at the 2012 Annual Meeting of the American Society of Clinical Oncology (ASCO). It builds on previous research showing the vaccine, known as AE37, to safely and effectively raise immunity against human epidermal growth factor receptor 2 (HER2) an oncoprotein that promotes tumor growth and is expressed to some extent in 75-80% of breast cancer tumors.

The researchers found that patients who received the vaccination had an estimated recurrence rate of 10.3% compared to 18% in the control group at a median follow up of 22 months. This represented a 43% reduction in the risk of recurrence.

"The vaccine educates the immune system to recognize HER2 as an invader," said Elizabeth Mittendorf, M.D., assistant professor in the Department of Surgical Oncology at MD Anderson and the trial's national principal investigator. "By introducing it into women who have had breast cancer, our goal is to instruct the immune system to immediately recognize any recurring cancer cells and orchestrate an attack."

Building a Powerful Vaccine

The AE37 peptide vaccine used in this study is a hybrid modified to increase its potency in generating an immune response specific to cancer cells expressing HER2. It consists of a fragment of the HER2 protein (AE36), a MHC Class II epitope, linked to an Ii-Key peptide. Together, they work to stimulate a robust CD4+ T cell response, prompting the components of the immune system to seek and destroy tumor cells.

To help T cells better recognize AE37, researcher
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Transplant Procedure Creates Hybrid Immune System to Combat Rejection
2. New hybrid NOSH aspirin as possible anti-cancer drug
3. New hybrid imaging device shows promise in spotting hard-to-detect ovarian cancer
4. Individuals with partial hearing loss may benefit from hybrid cochlear implant
5. UCLA uses new hybrid, precision heart procedures to help stop deadly arrhythmias
6. Phybridge Network Solution Achieves Avaya “Compliant” Status
7. Rare hybrid cell key to regulating the immune system
8. Phybridge Named "Cool Vendor" by Leading Analyst Firm
9. TCT for Surgeons course will highlight hybrid surgical and interventional techniques
10. Phybridge Inc. Joins the Cisco Developer Network and Completes Cisco Interoperability Verification Testing
11. Cancer vaccine combination therapy shows survival benefit in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... (PRWEB) April 27, 2015 Telematics Berlin ... tier 1&2 suppliers, associations, CE players and the government ... has opened to the car. This year’s panel on ... DG-Move at the European Commission, is an opportunity to ... and define a European Automotive Security Standard for years ...
(Date:4/27/2015)... 27, 2015 Attorney Dan Newlin, of the ... and protecting his clients, took that commitment to a whole ... code which makes it easier for existing and potential clients ... building his brand and added value to the firm’s services, ... area where Newlin has law offices. , “I knew the ...
(Date:4/27/2015)... Scooter Direct is now offering Pride ... price of only $929.00, marked down from the MSRP ... is known for offering quality mobility solutions to its ... wheel chairs, lift chairs, and their accessories at unbeatable ... of Go Go Traveller Elite, a senior store manager ...
(Date:4/27/2015)... On the top floor of the luxurious Beverly ... Los Angeles, CA, Per Wickstrom had an in-depth conversation ... of Orange County” Gretchen Christine Rossi. , In ... “Salute to the Oscars” celebration, sponsored by Choices Recovery, ... Wickstrom, Rossi felt that the evening’s interviews would not ...
(Date:4/27/2015)... Denver, Colorado (PRWEB) April 27, 2015 ... a ground-breaking solution to a problem that has ... marketing and advertising campaigns: by announcing the ... engine of its kind. , Officially launched ... industry and was created to index only marijuana-related ...
Breaking Medicine News(10 mins):Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 3Health News:Dan Newlin Hashtags It With #Dan 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 3Health News:Per Wickstrom Shares His Vision of Choices Recovery with Reality TV Star Gretchen Christine Rossi 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 3
... risk factor for active tuberculosis (TB) disease, according to a ... research analyzed data from nearly 17,000 individuals in Taiwan as ... While past studies have reported increased mortality among TB patients ... direct effect of smoking on active TB incidence using a ...
... ... professionals , ... August 23, 2009 -- An aging population and medical advances are a couple of ... (NRAF) is honoring the difference they make during the 2009 National Rehabilitation Awareness ...
... and methods, experts say simple CPR works best , SUNDAY, ... to participating in a flurry of activity when trying to ... IVs, placing a breathing tube, performing defibrillation to restart the ... advanced techniques saves lives as well as ordinary cardiopulmonary resuscitation, ...
... , LOUISVILLE, Ky., Aug. 22 A top medical ... Legion and colleague veterans service organizations can play a key role ... national suicide prevention coordinator, in pointing to the 5,000 self-inflicted deaths ... of our responsibility to own up to that. There,s no reason ...
... YouTube ... , ... August 22, 2009 -- Over 50 million American men suffer from hair loss. With that ... male pattern hair loss sufferer, Kevin Nalty (a.k.a. "Nalts") to raise awareness about hair loss ...
... Aug. 7, 2009 Dr. Glen Weiss of ... this week announced two significant advances in treating lung ... Weiss, M.D., an Associate Investigator in TGen,s Cancer and ... TGen Clinical Research Services at Scottsdale Healthcare, made both ...
Cached Medicine News:Health News:Smoking increases risk of developing active TB 2Health News:Smoking increases risk of developing active TB 3Health News:Medical Advances, Population Changes Fuel Demand for Rehabilitation Professionals 2Health News:It's Back to Basics to Save a Life 2Health News:It's Back to Basics to Save a Life 3Health News:The American Legion Can Play Key Role in Vets' Suicide Prevention, Says VA 2Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 2Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 3Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 4Health News:Advances in lung cancer research announced at conference 2
(Date:4/27/2015)... MILAN , April 27, 2015  USL di ... Italian province of Reggio Emilia, has implemented Zebra ... throughout the hospital. The Wireless Network Solution ... patients, medical records securely and in real time via ... available at all times. Zebra also provides employee and ...
(Date:4/27/2015)... 27, 2015  Novira Therapeutics, Inc., a privately held, ... of chronic hepatitis B virus (HBV) infection, today announced ... HBV core inhibitor candidate, NVR 3-778, at the 2015 ... of the Liver (EASL) in Vienna, Austria ... 3-778 from studies performed in a humanized UPA/SCID mouse ...
(Date:4/27/2015)... , April 27, 2015 - ... Process Patent by the State Intellectual Property Office of ... Based on Pooling Technology  - A New Treatment ... (CLI)    - About 20% of Elderly Urban ... in Women is Substantially Higher Than in Men. CLI is ...
Breaking Medicine Technology:Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 2Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 3Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 4Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 5Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 2Novira Therapeutics Announces Presentation of Preclinical Antiviral Data for NVR 3-778 at EASL 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 2Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 4
Midstream Catch Kits...
... The BladderScan® is a portable, noninvasive ... is battery-operated, easy to use, and quickly ... minutes, you can use the BladderScan® to ... bladder volume. The BladderScan® supplies the information ...
... The Pediatric BladderScan® is ... Diagnostic Ultrasound's trusted family ... enabling healthcare providers to ... volume noninvasively, this easy-to-use, ...
... BVI 6300 Bladder Monitor is a ... the healthcare provider to enable patients ... ongoing basis. It is easy to ... so the patient can make informed ...
Medicine Products: