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Hybrid screening strategy emerges for colorectal cancer
Date:8/27/2013

A strategy that combines two effective colorectal cancer screening methods, fecal immunological test and colonoscopy, may improve prevention and detection of colorectal cancer and reduce costs, according to a new study in Clinical Gastroenterology and Hepatology (CGH), the official clinical practice journal of the American Gastroenterological Association.

The study used a simulation model to test a hybrid screening strategy consisting of annual or biennial fecal immunological test at younger ages (50 to 65 years of age), combined with a single colonoscopy when the patient is 66 years old. This approach led to substantial reductions in colorectal cancer incidence and mortality, comparable to those of the currently recommended strategies, and reductions in costs. Adherence to colonoscopy at age 66 is critical to maintain the effectiveness of this hybrid screening program.

"Although colonoscopy is recognized as the most comprehensive colorectal examination, its role in screening is viewed very differently across health-care systems. Fecal immunochemical tests are emerging as the tests of choice in many population-based colorectal cancer screening programs," said Uri Ladabaum, MD, MS, study author from the Division of Gastroenterology and Hepatology at Stanford University School of Medicine. "This modeling study suggests that a hybrid screening approach of fecal immunological test at younger ages and then a well-timed single colonoscopy in the mid-sixties offers the potential to deliver health benefits that are similar to those of the current screening strategies with lower resources demand."

Colorectal cancer is the second leading cause of cancer deaths among men and women in the U.S., according to the Centers for Disease Control and Prevention. This form of cancer is largely preventable through proper screening. The AGA, in conjunction with U.S. Multi-Society Task Force on Colorectal Cancer, the American Cancer Society
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Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

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