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Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research
Date:5/3/2010

be your neighbor who is talking to you about the importance of having a mammogram." Gloria Coronado, Ph.D., an associate member of the Hutchinson Center's Public Health Sciences Division, will lead the project.

PROJECT 2: Metabolic Response to Western versus Indigenous Diets in Hispanic Women This feeding study, which will involve 50 first- and second-generation Seattle-area Hispanic women and be carried out in the Hutchinson Center's Human Nutrition Laboratory, will assess how ancestral genetic variation may influence how the body metabolizes food comparing a traditional, indigenous Mexican diet to a more modern, Westernized way of eating. "We hypothesize that the biological response to a Western diet will produce a detrimental metabolic profile, leading to obesity, while the physiologic response to an indigenous Mexican diet will produce a favorable metabolic profile," said project leader and nutritional scientist Marian Neuhouser, Ph.D., an associate member of the Hutchinson Center's Public Health Sciences Division. Studying the interplay of genes and diet is an important issue in the realm of health disparities because nearly 80 percent of U.S. Hispanic women are overweight or obese, and obesity increases the risk of numerous chronic diseases, including breast cancer. The researchers will measure metabolic response to modern versus traditional diets by measuring various biomarkers in the blood, from insulin and glucose to C-reactive protein, all signs of inflammation. "This project will provide important data for understanding the causes of obesity in Hispanic women, which can be used to design effective programs for prevention," Thompson said.

PROJECT 3: Risk Factors for Triple-negative and HER2-overexpressing Breast Cancer Among Hispanic Women and Non-Hispanic Women This project is the largest of its kind to study the origins and causes of poor-prognosis breast cancers in Hispanic women. The project aims to identify risk factors related to triple
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

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