Navigation Links
Hundreds of random mutations in leukemia linked to aging, not cancer
Date:7/19/2012

Hundreds of mutations exist in leukemia cells at the time of diagnosis, but nearly all occur randomly as a part of normal aging and are not related to cancer, new research shows.

Scientists at Washington University School of Medicine in St. Louis have found that even in healthy people, stem cells in the blood routinely accumulate new mutations over the course of a person's lifetime. And their research shows that in many cases only two or three additional genetic changes are required to transform a normal blood cell already dotted with mutations into acute myeloid leukemia (AML).

The research is published July 20 in the journal Cell.

"Now we have a very accurate picture of how acute leukemia develops," says senior author Richard K. Wilson, PhD, director of The Genome Institute at Washington University. "It's not hundreds of mutations that are important but only a few in each patient that push a normal cell to become a cancer cell. Finding these mutations will be important for identifying targeted therapies that can knock down a patient's cancer."

The study is the first to investigate how often mutations typically develop in healthy stem cells in the blood. These immature cells in the bone marrow give rise to all the blood cells in the body.

AML is a blood cancer that develops when too many immature blood cells crowd out the healthy cells. In recent years, Washington University researchers at the Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine have sequenced the genomes of 200 patients with AML to try to understand the mutations at the root of the disease.

Without fail, each patient's leukemia cells held hundreds of mutations, posing a conundrum for scientists, who have long believed that all the mutations in a cancer cell are likely to be important for the disease to progress.

"But we knew all of these mutations couldn't be important," says co-
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Tai Chi increases brain size, benefits cognition in randomized controlled trial of Chinese elderly
2. Canada should significantly increase its funding of randomized clinical trials
3. Evolutionary information improves discovery of mutations associated with diseases
4. Study finds new gene mutations that lead to enlarged brain size, cancer, autism, epilepsy
5. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
6. Study sheds new light on role of genetic mutations in colon cancer development
7. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
8. Cancer may require simpler genetic mutations than previously thought
9. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
10. Researchers Find Gene Mutations That May Be a Key to Autism
11. A new target in acute myeloid leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hundreds of random mutations in leukemia linked to aging, not cancer
(Date:10/20/2014)... Principle Business Enterprises, a family owned ... top-of-the-line absorbent products. The company has recently made ... brand, Tranquility® Premium Protection absorbent products. The company ... its packaging a new look, and is currently working ... the public. , The new website, developed with Thread ...
(Date:10/20/2014)... PA (PRWEB) October 20, 2014 ... Matthew Voicheck as Assistant Director of their ... role in managing the innovative turnkey drug sourcing, ... , Matthew brings over 12 years of industry ... joins Myoderm at the peak of their international ...
(Date:10/20/2014)... Succeed is proud to announce that they ranked ... the Every Body Walk! campaign by Kaiser Permanente. ... encourages workers to be more active outside of the workplace. ... at the end of September, was a friendly competition between ... Participating companies gave their staff pedometers and each day, ...
(Date:10/20/2014)... 2014 National Teen Driver Safety Week is ... Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ) is joining ... of teen drivers to talk to their teens and always ... vehicle crashes are the leading cause of death for U.S. ... fatal crashes, and 859 (42%) of those teen drivers were ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, The Center ... hospital ROI on membership dues at 12.5. In other words, ... in value to member hospitals. The calculation used to determine ... , “This is the first time we’ve actually been ... methodology is really sound,” said Bill Ryan , president ...
Breaking Medicine News(10 mins):Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4
... River Valley Water Supply Project's key agenda is to transfer ... heavily populated areas in the red river drainage basin. // ... proposition, due to a perceptible risk of foreign biota filling ... of the Earth Canada, feels that a task of such ...
... pneumonia, bronchitis and other infections. Bristol-Myers Squibb Co. (BMY) ... Food and Drug Administration said that the drug would ... blood-sugar changes due to this drug. ,This ... serious cases of hypoglycemia (low blood sugar) and hyperglycemia ...
... Ranbaxy has introduced a diagnostic test for Bird Flu that ... accurate results within 24 hours. Named as RT-PCR test, // ... be available in a day. Certainly a blessing in the ... available to check for Bird Flu report results only after ...
... of dance lovers in discos has been found to work ... was first synthesised in 1910. It was patented two years ... suppressant. ,The study finds that loud music exacerbates ... was conducted by Italian scientists on rats. Who were given ...
... on either couple, men seem to be more vulnerable, according ... his research team from Harvard Medical School. ,The ... the risk of illness in the other partner in a ... ,They found that when a spouse was hospitalized, ...
... Medicines Racket is growing at alarming proportions. The United Nations ... wide initiative , by way of a task force team ... of counterfeit drugs. A three day meeting is underway in ... - Pharamaceutical companies, Regulatory bodies and groups which represent the ...
Cached Medicine News:Health News:The effects of Ecstasy more pronounced in presence of music 2
(Date:10/20/2014)... -- Indianapolis interventional medical device maker NICO Corporation ... visualization leader Synaptive Medical announced today ... that they have joined forces to integrate their ... the first of its kind and will make ... BrainPath® interventional access technology and Synaptive,s BrightMatter™ real-time ...
(Date:10/20/2014)...  AnaptysBio, Inc., a leader in the discovery ... appointment of Marco Londei , M.D. as ... preclinical and clinical development of AnaptysBio,s proprietary antibody ... welcome Dr. Londei to AnaptysBio,s executive leadership team," ... Executive Officer of AnaptysBio. "Dr. Londei,s extensive expertise ...
(Date:10/20/2014)... -- Norgine B.V. today announced that the ... preparation, NER1006, presented at the 79 th Annual ... Philadelphia, PA , has met its ... endpoint of cleansing success. The study demonstrated high quality ... in screening colonoscopy patients. [1] (Logo: ...
Breaking Medicine Technology:Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 2Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 3Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 4Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 5AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Positive Results from Phase II Data Show NER1006 Achieves High Quality Bowel Cleansing Efficacy 2
... 2011 The Radiosurgery Society™ (RSS), a non-profit organization ... clinical practice of stereotactic body radiotherapy (SBRT) and radiosurgery ... at the La Costa Resort in Carlsbad, Calif.   ... Radiosurgery Society has been expanded to serve as a ...
... To reward loyal shoppers, CVS/pharmacy today ... multiple free gift cards just by shopping for essentials ... began on Sunday October 16 and will go through ... can earn $10 gift cards to Macy,s, Gap, Applebee,s, ...
Cached Medicine Technology:Announcing The Radiosurgery Society™ And Its 2012 SRS/SBRT Scientific Meeting 2Announcing The Radiosurgery Society™ And Its 2012 SRS/SBRT Scientific Meeting 3Save Big This Fall with CVS/pharmacy's Free Gift Cards Promotion 2Save Big This Fall with CVS/pharmacy's Free Gift Cards Promotion 3
Straight 9 mm downcutting Royce blade. Can be placed in closed handle for protection. Handle length folded 109 mm, 4.3 inches. Blade can be set automatically and rigidly at any point from straight to...
Duckbill. 3.5 mm tip. Light curve....
Duckbill type, sharp. 3 mm x 8 mm curved blade. Octagonal handle....
4 mm x 9 mm tip....
Medicine Products: