Navigation Links
Hundreds of alterations and potential drug targets to starve tumors identified
Date:4/22/2013

mote tumor formation as a result of efflux from mitochondria and accumulation of their substrates, fumarate and succinate. The researchers found that in colon cancer, accumulation of these metabolites may be caused by a significant decrease in the enzymes' expression. This was confirmed when metabolomics data from colon tumor patients showed significantly higher concentrations of fumarate in tumors than in normal tissue.

"These are just several examples of how cancer cells use various creative mechanisms to hijack the metabolism of native cells for their own purposes," said Dr. Vitkup.

For cancer researchers looking for new drug targets, Dr. Vitkup's team also found hundreds of differences between normal and cancer cells' use of isoenzymes. This opens up additional possibilities for turning off cancer's fuel and supply lines. Isoenzymes often catalyze the same reactions, but have different kinetic properties: Some act quickly and sustain rapid growth, while others are more sluggish. In kidney and liver cancers, for example, a quick-acting aldolase isoenzymesuitable for fast cell proliferationwas found to be more prevalent than the more typical slow-moving version found in normal kidney and liver tissue. Although a few examples of differential isoenzyme expression in tumors were already known, the Columbia researchers identified hundreds of isoenzymes with cancer-specific expression patterns.

"Inhibiting specific isoenzymes in tumors may be a way to selectively hit cancer cells without affecting normal cells, which could get by with other isoenzymes," said Dr. Hu.

In fact, a recent study from Matthew Vander Heiden's laboratory demonstrated the potential of targeting a specific isoenzyme, pyruvate kinase M2, expression of which often increases in tumors. "The comprehensive expression analysis suggests that a similar approach could potentially be applied in multiple other cases," said Dr. Vander Heiden.

Targeting metabolis
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Hundreds of alterations and potential drug targets to starve cancer tumors identified
2. Medtronic Infuse Bone Graft Lawsuits: Bernstein Liebhard LLP Notes New Report Predicting Hundreds of Medtronic Infuse Lawsuits
3. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
4. Physicians at Pain Care Bring Hope to Hundreds of Pain Management Patients Who Previously Had None Through Use of a New Procedure Called Spinal Cord Stimulation
5. Hundreds of random mutations in leukemia linked to aging, not cancer
6. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
7. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
8. Tekturna Infographic Released by d’Oliveira & Associates Imparts Potential Side Effects of Blood Pressure Drug
9. Key bone marrow protein identified as potential new leukemia treatment target
10. UCLA researchers find potential link between auto pollution, some childhood cancers
11. Flies model a potential sweet treatment for Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... 01, 2014 Recently, BambooIndustry.com, one of the ... with a new selection of bamboo veneers . Additionally, ... percent off) for these high quality products. The promotion will ... senior spokesman says that its top quality veneers are hot ... the new designs of bamboo veneers. All these items are ...
(Date:8/31/2014)... With years of hard work, Delta has now become ... Recently, the company has updated its wheel loader ... All these items are guaranteed to be great. Additionally, they ... It is true that all items in Delta’s used ... specialists. The firm is making full efforts to help worldwide ...
(Date:8/31/2014)... 31, 2014 Asked to offer ... between "Bioavailability" and "absorption," Dr. Priya Khan, Director ... great interest. "Bioavailability" and "absorption" are possibly ... the supplement industry, second perhaps only to the ... and absorption, while related, are not the same. ...
(Date:8/31/2014)... Ticket Down is a dependable source ... Goods Park in suburban Denver. The Mexican national ... other international teams on USA soil. , ... soccer coach aboard, Miguel Herrera, and he has had excellent ... World Cup in Brazil, the Mexican team played quite well ...
(Date:8/31/2014)... (PRWEB) September 01, 2014 Market ... System Industry, 2009-2019 is a professional and in-depth ... System industry. The report firstly reviews the basic ... application and manufacturing technology. , The report then ... Harvesting System listing their product specification, capacity, production ...
Breaking Medicine News(10 mins):Health News:High Quality Bamboo Veneers from Bambooindustry.com Receive International Attention 2Health News:Delta Updates Its Wheel Loader Assortment With A Lot Of Cheap Used Cat 966 Loaders 2Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 2Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 3Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 4Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 3Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4
... The following is a statement of Matthew L. ... http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO )The Campaign for Tobacco-Free ... his leadership role in Senate committee approval of ... Administration (FDA) regulatory authority over tobacco products, including ...
... a statement of Matthew L. Myers, President, Campaign ... ) The Campaign for Tobacco-Free Kids applauds ... role in Senate committee approval of legislation that ... regulatory authority over tobacco products, including the authority ...
... of Clinical Oncology. , ... Evanston, IL (Vocus) May 20, 2009 -- ... David J. Winchester , FACS, M.D., Chief of General Surgery and Surgical ... cancer has spread to the lymph nodes may not need a ...
... Alan B. Miller to Retain Chairman and CEO Positions Michael ... Pa., May 20 The Board of Directors of Universal ... nation,s largest hospital companies, today announced the election of Marc ... of Universal Health Service,s Chairman and Chief Executive, Alan Miller, ...
... On May 20, 2009, the US District Court for the ... AZN ) for an injunction barring Apotex (Apotex, ... AstraZeneca,s PULMICORT RESPULES (budesonide inhalation suspension) in the US. ... March 30, 2009, the US Food and Drug Administration granted ...
... SCHAUMBURG, Ill., May 20 Sagent Pharmaceuticals, Inc., ... it has raised $30 million in a second ... strategic investors. The round was again led by ... support upcoming product launches, development activities and strategic ...
Cached Medicine News:Health News:Sen. Jeff Merkley Votes to Protect America's Kids From Tobacco 2Health News:Sen. Jeff Merkley Votes to Protect America's Kids From Tobacco 3Health News:Sen. Tom Harkin Votes to Protect America's Kids From Tobacco 2Health News:Sen. Tom Harkin Votes to Protect America's Kids From Tobacco 3Health News:Breast Cancer Patients May be Spared Additional Surgery 2Health News:Breast Cancer Patients May be Spared Additional Surgery 3Health News:Universal Health Services, Inc. Announces Marc D. Miller Named President of Universal Health Services 2Health News:Court Grants AstraZeneca Preliminary Injunction Against Apotex in PULMICORT RESPULES Patent Litigation 2
(Date:8/29/2014)... Aug. 29, 2014 Does your doctor know what ... doctors have recommended marijuana to the over 112,000 currently registered ... the majority of the other roughly 20,300+ active physicians listed ... little about it – even though a poll in February ... say they have tried it. "With marijuana ...
(Date:8/29/2014)... , Aug. 29, 2014 Diseases largely ... a generation ago are returning. Measles was declared eliminated ... in 2014 as of August 15—the highest incidence in ... public health department declared whooping cough a problem of ... are getting sick and dying from these preventable diseases—in ...
(Date:8/29/2014)... Calif. , Aug. 29, 2014  Abaxis, Inc. ... manufacturing point-of-care blood instrumentation and consumables to the medical, ... Severson , Chairman and Chief Executive Officer, will present ... Ideas Conference 2014 on Tuesday, September 9, 2014 at ... the Omni Berkshire Place Hotel in New ...
Breaking Medicine Technology:Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2
... (OTC Pink: MHCC) announced the appointment of Ed Joyce ... Chris Amandola commented, "Ed brings deep experience from multiple ... join our advisory board.  Our Company,s advantage is to ... individuals and he will be a tremendous addition to ...
... March 7, 2012  Amgen Inc. ("Amgen") (NASDAQ: AMGN ... of the tender offer (the "Offer") by a wholly owned ... stock of Micromet, Inc. ("Micromet") (NASDAQ: MITI ) ... expired at 12:00 midnight, New York City time, at the ...
Cached Medicine Technology:Millennium HealthCare Appoints Ed Joyce to Company Advisory Board 2Amgen Completes Tender Offer for Outstanding Shares of Micromet, Inc. 2Amgen Completes Tender Offer for Outstanding Shares of Micromet, Inc. 3Amgen Completes Tender Offer for Outstanding Shares of Micromet, Inc. 4
Straight shafts with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Colibri style tips. Double toothed tips with 0.10 mm teeth spaced 1 mm apart and 7 mm tying platform. Wide serrated handle with polished finish....
Straight shafts with teeth and 6 mm crisscross serrated tying surfaces. Serrated handle with polished finish....
Serrated, 10 mm tips angled 30 degrees. Serrated cross action handle with polished finish....
Medicine Products: