Navigation Links
Hundreds of alterations and potential drug targets to starve cancer tumors identified
Date:4/21/2013

Right now we have something like a static road map. We know where the streets are, but we don't know how traffic flows through the streets and intersections," said Jie Hu, PhD, a postdoctoral researcher at Columbia and first author of the study. "What researchers need is something similar to Google Traffic, which shows the flow and dynamic changes in car traffic."

Drs. Hu and Vitkup's study is an important step toward achieving this dynamic view of cancer metabolism. Notably, the researchers found that the tumor-induced expression changes are significantly different across diverse tumors. Although some metabolic changessuch as an increase in nucleotide biosynthesis and glycolysisappear to be more frequent across tumors, others, such as changes in oxidation phosphorylation, are heterogeneous.

"Our study clearly demonstrates that there are no single and universal changes in cancer metabolism," said Matthew Vander Heiden, MD, PhD, assistant professor at MIT, and a co-author of the paper. "That means that to understand transformation in cancer metabolism, researchers will need to consider how different tumor types adapt their metabolism to meet their specific needs."

The researchers also found that expression changes can mimic or cooperate with cancer mutations to drive tumor formation. A notable example is the enzyme isocitrate dehydrogenase. In several cancers, such as glioblastoma and acute myeloid leukemia, mutations in this enzyme are known to produce a specific metabolite2-hydroxyglutaratethat promotes tumor growth. The Columbia team found that isocitrate dehydrogenase expression significantly increases in tumors with the recurrent mutations. Such an overexpression may create an efficient enzymatic factory for overproduction of 2-hydroxyglutarate.

The analysis also led the researchers to an interesting finding in colon cancer. In several other cancers, mutations in two enzymessuccinate dehydrogenase and fumarate hydratasecan pro
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Hundreds of random mutations in leukemia linked to aging, not cancer
2. Physicians at Pain Care Bring Hope to Hundreds of Pain Management Patients Who Previously Had None Through Use of a New Procedure Called Spinal Cord Stimulation
3. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
4. Medtronic Infuse Bone Graft Lawsuits: Bernstein Liebhard LLP Notes New Report Predicting Hundreds of Medtronic Infuse Lawsuits
5. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
6. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
7. Study identifies potential treatment for lethal childhood leukemia
8. McMaster researchers find potential for new uses of old drug
9. Army researcher develops potential vaccine carrier
10. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
11. New study of NIH funding allocations suggests potential efficiency gains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... , ... On May 30th, 2015, Best Drug Rehabilitation, a results-based substance abuse ... Mission” benefit concert in Mendon, IL. Held in the Show Barn at the Adams ... education programs in the underfunded local school districts of Mendon at neighboring Quincy, IL. ...
(Date:8/28/2015)... ... August 28, 2015 , ... Saint Petersburg, FL ... with zero fat, carbs, sugar, gluten, lactose or caffeine in a convenient 2 ... 2015 SupplySide CPG Editor’s Choice Awards. , Five consumer packaged goods (CPG) products ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... for documenting and diagramming network and data center assets and audio-video devices, recently ... Model, Cisco Nexus 5000 Series, HP ProLiant Gen9, EMC VNX Series , Super ...
(Date:8/28/2015)... ... August 28, 2015 , ... Medical Solutions, one of the ... Places to Work in Healthcare by Modern Healthcare and will be honored at ... in its eighth year, the Best Places to Work in Healthcare program recognizes outstanding ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... a three-year accreditation for its adolescent residential, counseling, day treatment and intensive family ... it meets international standards for quality and its pursuit of excellence. As a ...
Breaking Medicine News(10 mins):Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 2Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 3Health News:West Ridge Academy Awarded CARF Three-Year Accrediation 2
... ... branded accredited programs for patient safety, fall prevention and bed safety. ... ... to bundle Health Care Brands as an educational opportunity for each company’s healthcare customers. ...
... ... to grow sales and reduce its impact on the environment. While renewing ... Foods, the largest Home Food service company in America, discovered they had ... once again measured and offset 100% of Service Foods’ scope 1 and ...
... , INDIANAPOLIS , Feb. 16 ... Day previously scheduled for February 23, 2010 , and announced that ... on March 17, 2010 , at 8:30 a.m. Eastern Daylight ... income to be at least $6.00 per share, subject to ...
... ... room infrastructure announced a 237% year over year revenue growth. Unlimited use data room offer ... ... infrastructure for corporate transactions and secure extranets today announced that it had year over year ...
... , ABBOTT PARK, Ill., Feb. 16 ... completed its EUR 4.5 billion ( $6.2 billion ) ... large and complementary portfolio of pharmaceutical products and expanding Abbott,s presence ... of the close, Abbott expects the acquisition to add approximately ...
... LYON, France , February ... of TCS 7560 and TCS 7561 Silbione(R) products designed,for the ... medical equipment). These two new silicone elastomers have,excellent "anti-slip" non-compression ... http://www.newscom.com/cgi-bin/prnh/20100216/377913 ) , Self-fixing ...
Cached Medicine News:Health News:Medical Nurse Training, Inc. Partners With Healthcare Companies to Develop Corporate Branded, Accredited Programs for Patient/Bed Safety and Fall Prevention/Protection 2Health News:Service Foods Reduces its Carbon Footprint and Grows Sales 2Health News:Service Foods Reduces its Carbon Footprint and Grows Sales 3Health News:WellPoint To Hold Conference Call and Webcast To Discuss 2010 Financial Outlook on March 17, 2010 2Health News:WellPoint To Hold Conference Call and Webcast To Discuss 2010 Financial Outlook on March 17, 2010 3Health News:WellPoint To Hold Conference Call and Webcast To Discuss 2010 Financial Outlook on March 17, 2010 4Health News:WellPoint To Hold Conference Call and Webcast To Discuss 2010 Financial Outlook on March 17, 2010 5Health News:Firmex Achieves 237% Annual Revenue Growth Despite Tough M&A Environment in 2009 2Health News:Firmex Achieves 237% Annual Revenue Growth Despite Tough M&A Environment in 2009 3Health News:Firmex Achieves 237% Annual Revenue Growth Despite Tough M&A Environment in 2009 4Health News:Abbott Completes Acquisition of Solvay Pharmaceuticals 2Health News:Abbott Completes Acquisition of Solvay Pharmaceuticals 3Health News:Bluestar Silicones Launches a New Range of Silbione(R) TCS 7560 & 7561 Elastomers for Lingerie, Support Stockings and Medical Textile Applications 2
(Date:8/27/2015)... 2015 According to a new market research ... Universal, Standing, Bariatric ), Material (Nylon, Padded, Canvas), Usage Type (Disposable, ... by MarketsandMarkets, the Medical Lifting Sling Market is poised to reach ... at a CAGR of 11.4 % from 2015 to 2020. ... rket data T ables and 65 ...
(Date:8/27/2015)... Women Grow , the fastest-growing professional networking organization for women ... Cannabis World Congress & Business Exposition (CWCBExpo) in ... sessions. CWCBExpo in LA will take place September 16-18, 2015 ... in Los Angeles, CA , and is ... marijuana industry. The Women Grow tracks at ...
(Date:8/27/2015)... Aug. 27, 2015  A mere one in seven ... Allen Hamilton . A new white paper ... are impeding and disrupting manufacturers, success. The ... Improve Value In Product Development Processes provides insight ... and how it affects the product development process resulting ...
Breaking Medicine Technology:Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4New White Paper Reveals How Manufacturers Can Improve Product Development Processes 2
... 18 Telik, Inc.,(Nasdaq: TELK ) announced ... small molecule kinase inhibitors will be presented at ... in,San Francisco. The presentation, "In Vitro and Vivo ... VEGFR2" (Abstract # C206) will be,on Thursday, October ...
... MRSA, WASHINGTON, Oct. 18 Building on the ... infection by 50 percent,the Department of Veterans Affairs (VA) ... of its 153 hospitals., In addition to emphasizing ... special precautions, VA facilities monitor,all incoming patients on key ...
Cached Medicine Technology:VA National Campaign Takes Aim at Resistant Staph Infections 2
Endoscopes are also available in fully autoclavable models in 1.8, 2.7, 4.0. 5.0 and 10.0 mm diameters. Manufactured with precise swiss lenses. Built-in temperature measuring device to exactly determ...
Endoscopes are also available in fully autoclavable models in 1.8, 2.7, 4.0. 5.0 and 10.0 mm diameters. Manufactured with precise swiss lenses. Built-in temperature measuring device to exactly determ...
Cottle Tenaculum Skin Hook. 5 1/2" small, shallow curve....
Large deep curve....
Medicine Products: