Navigation Links
Human umbilical cord blood cells found to enhance survival and maturation of key brain cells
Date:12/14/2010

Laboratory culture (in vitro) studies examining the activity of human umbilical cord blood cells (HUCB) on experimental models of central nervous system aging, injury and disease, have shown that HUCBs provide a 'trophic effect' (nutritional effect) that enhances survival and maturation of hippocampal neurons harvested from both young and old laboratory animals.

"As we age, cognitive function tends to decline," said Alison E. Willing, PhD, a professor in the University of South Florida's (USF) Department of Neurosurgery and Brain repair and lead author for a study published in the current issue of Aging and Disease (www.aginganddisease.org) . "Changes in cognitive function are accompanied by changes in the hippocampus, an area of the brain where long term memory, as well as other functions, are located, an area of the brain among those first to suffer the effects of diseases such as Alzheimer's disease."

According to Dr. Willing and her USF co-authors, these changes contribute to stroke and dementia in the aging population when neural cells become more susceptible to stressors and disease processes. Because HUCB cells have received attention as an alternative source of stem cells that have been studied and shown to be effective with wide therapeutic potentials, how the cells might be used to repair the diseased, as well as normally aging brain, has become an important question.

"It is important to understand how these cells may be manipulated to support hippocampal function in order to develop new therapies," she explained. "Accordingly, this study sought to examine the potential for HUCBs to enhance proliferation and increase survival of hippocampal cells derived from aging adult rat brains."

The study found that HUCBs were not only able to protect hippocampal neurons taken from the brains of young adult and aged rats, but also promoted the growth of dendrites - the branching neurons acting as signaling nerve communicatio
'/>"/>

Contact: Randolph Fillmore
rfillmor@health.usf.edu
813-974-0868
University of South Florida (USF Health)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cognitively-impaired human research subjects need better protection
2. Species Extinctions May Spell Trouble for Human Health
3. Experts urge US to create emergency cholera vaccine stockpile for humanitarian use
4. Female fish -- and humans? -- lose interest when their male loses a slugfest
5. To be or not to be? Public event examines question of human identity and consciousness
6. PARP inhibitor, MK-4827, shows anti-tumor activity in first trial in humans
7. HFES announces Release of Reviews of Human Factors and Ergonomics, Volume 6
8. Rogue gene hijacks stem cells to jumpstart human cancer
9. Scientists Use Tarantulas to Explore Human Fear
10. Dangerous chemicals in food wrappers likely migrating to humans: U of T study
11. Early Humans More Advanced Than Thought
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... that a new drug could prove useful in treating small ... cancer. , Scientists from the Cancer Research UK Manchester Institute, ... Manchester Cancer Research Centre, teamed up with experts at AstraZeneca, ... a drug known as AZD3965 - on small cell ... Clinical Cancer Research , also helps identify which patients ...
(Date:7/9/2014)... the first time, researchers have access to detailed information ... health care. A new study, called Our Health Counts, ... challenges faced by urban Aboriginal people in Canada ... The findings, published today in BMJ Open , ... the general population. , Researchers interviewed 554 First Nations ...
(Date:7/9/2014)... innovative tool that captures heretofore hidden ways that cells ... protein that makes breast cancer cells more likely to ... cancer,s spread in part by blocking two other proteins ... suggests these two disease processes could have unexpected ties. ... 10 issue of Nature , points to the ...
(Date:7/9/2014)... policing injection drug users in Russia might contribute ... A study, conducted by researchers from Boston University ... with St. Petersburg Pavlov State University, sought to ... health outcomes of a cohort of HIV-positive people ... who were arrested by police were more likely ...
(Date:7/9/2014)... Researchers from Montefiore Medical Center and the ... University will present new findings at the Alzheimer,s Association ... 17 in Copenhagen, Denmark. Data from the four abstracts ... cognitive normality to mild cognitive impairment and dementia. The ... , established in 1980 to examine healthy brain aging ...
Breaking Medicine News(10 mins):Health News:New drug active against most aggressive type of lung cancer cells 2Health News:Urban Aboriginal people face unique health challenges 2Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:BU researchers relate arrests with HIV risk environment 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3
... the illegal organ trade in Tamil Nadu, led to the ... illegal organ trade; their license has been revoked. This operation ... the sale of kidneys by poor fisherwomen on Chennai coast. ... cause notices. ,The laws pertaining to organ transplant ...
... developed a new method of delivering drugs to fight ... which they say would be less// physically traumatic to ... at the National University of Singapore's department of chemical ... they cannot be detected under a standard microscope, are ...
... Bird flu patients who get early treatment with the antiviral ... steroids can do more harm// than good, the World Health ... agency was reporting on the preliminary conclusions of international experts ... treatments, including the attempt by doctors in some countries to ...
... religious community have called upon the US Congress to cast ... , This program, State Children's Health Insurance ... children whose parents are not offered health insurance through their ... April 23, faith leaders, heads of the Detroit Medical Center's ...
... Pharmaceutical companies will be required to declare the production ... planning to introduce// into the Thai market, Siriwat Thiptaradol, ... the Bangkok Post reports. ,According to ... is included in a new bill being considered by ...
... more of a burden for the women than a boon. The ... //the right kind of health care that is needed. They are ... of having insurance. , A national survey conducted by the ... on health and social issues found that the women patients don’t ...
Cached Medicine News:Health News:Tamiflu Key to Treat Bird Flu, Avoid Steroids: WHO 2Health News:Call To Extend Health Insurance To All Children 2Health News:Thailand Directs Pharma Companies to Declare Production Cost of Drugs 2Health News:Costlier Health Care Weigh Downs the Women 2Health News:Costlier Health Care Weigh Downs the Women 3
(Date:1/14/2014)... , Jan. 14, 2014 HeartWare International, Inc ... of less invasive, miniaturized circulatory support technologies that are ... that it expects revenues for the fourth quarter of ... 2013 revenues to approximately $208 million. "Our ...
(Date:1/14/2014)... 14, 2014 InformEx, North America,s ... chemistry, will hold the 30 th edition of its ... Convention Center from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ... pharmaceutical, fine chemical and specialty chemical companies will take part ...
(Date:1/14/2014)... 14, 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio ... acquired Progressive Home Medical Equipment, Inc. ("Progressive") of ... of the acquisition were not disclosed. Progressive ... a wide range of sleep, mobility, and respiratory products to ...
Breaking Medicine Technology:HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3
... Mumps IgG Enzyme- linked Immunosorbent Assay (ELISA) ... determination of IgG antibody to Mumps virus ... be used for the determination of immune ... be used to demonstrate seroconversion or a ...
The DSL-05-10-MUG Mumps IgG Enzyme-Linked Immunosorbent Assay (ELISA) kit provides materials for the determination of IgG-class antibodies to Mumps Virus in human serum. This assay is intended for in...
With BareWire technology, the wire crosses the lesion first, independent of the filter and delivery catheter. All other actions, including filter placement and retrieval, balloon dilatations, and ste...
... Ultra Laboratory has been uniquely designed ... single facility to integrated networks spanning ... to management reporting and accounts receivable, ... precise laboratory management. All system modules ...
Medicine Products: