Navigation Links
Human stem cells provide a new model for Lou Gehrig's disease
Date:2/22/2009

February 23, 2009, Cambridge, UK Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating condition in which motor neuron degeneration causes progressive loss of movement and muscle tone, leading to death. Overcoming the limited success of previous models, a report published in Disease Models & Mechanisms (DMM), dmm.biologists.org describes how neurons can be derived from human stem cells, and engineered to mimic inherited ALS.

Researchers at the University of California Los Angeles developed an optimized protocol to generate motor neurons from human embryonic stem cells (ES cells), which express normal or mutant forms of the SOD-1 gene, which is linked to inherited, familial ALS. Resulting cells exhibit hallmark characteristics of motor nerve cells, and neurons expressing mutant SOD-1 display abnormalities typical of ALS. Defects included shortened cell projections and a reduced life span compared to cells containing the normal SOD-1 gene.

This human cell-derived model of ALS provides a new method of studying this disease and testing novel therapeutics. This is especially helpful as only one drug is approved to help slow ALS progression, and animal models currently used in drug development have had limited success. Additionally, this research may aid other gene-linked neurodegenerative diseases, as they too may benefit from studies in a human cell-derived model.


'/>"/>

Contact: Donna Perry
donna@biologists.com
44-122-343-3319
The Company of Biologists
Source:Eurekalert

Page: 1

Related medicine news :

1. Embryonic Stem Cells Repair Human Heart
2. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
3. Human Papilloma Virus vaccines may decrease chances of oral cancer
4. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
5. MassMutual Promotes Debra Palermino to Senior Vice President of Human Resources
6. Toddler Study Proves Humans Outsmart Apes
7. Human C-reactive protein regulates myeloma tumor cell growth and survival
8. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
9. AtriCure Reports First Human Implant of the Cosgrove-Gillinov Left Atrial Appendage Occlusion System
10. New class of RNA molecules may be important in human cancer
11. The Humana Foundation and Libraries for the Future Launch Health Literacy Pilot in Atlanta
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... ... prominently feature 150+ Hospital and Health System Executive Speakers including: , , ... President of the United States of America: George W. Bush , Boxing Legend, ... Sugar Ray Leonard , JD, Chairperson, McGuireWoods LLP: Amber McGraw Walsh , ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... help improve all aspects of people’s health and nutrition, announced its product Leyzene ... , Natural Subsistence develops nutritional supplements that help people improve all aspects ...
(Date:3/23/2017)... ... March 23, 2017 , ... The American Board of Quality Assurance and Utilization ... ABQAURP’s dedication to Health Care Quality and Management and Patient Safety. , It is ... the association, but also to the Health Care Quality and Patient Safety movements. Diplomates ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... MEDDEV 2.7/1 Rev. 4 Guidance, **An FDAnews Webinar**, April 4, 2017 — ... the new EU MDR language change the way manufacturers approach CERs? , ...
(Date:3/23/2017)... ... March 23, 2017 , ... “Beyond and Back”: a true-life ... is the creation of published author Bonetta Rose, a wife, mother and grandmother committed ... Published by Christian Faith Publishing, Bonetta Rose‘s new book presents actual events in the ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... ReNeuron reported in December 2016 positive Phase II trial ... not meeting the three-month time frame of a two-point improvement ... (ARAT). As a result, the company has confirmed that it ... Beyond CTX, we expect safety and efficacy data from its ... from its critical limb ischaemia (CLI) trial. Our rNPV has ...
(Date:3/23/2017)... , Mar 23, 2017 The Board ... to the Annual General Meeting, which is to take place on ... 2 in Lund, Sweden . ... Please see the attached notification, which ... Inrikes Tidningar. NeuroVive Pharmaceutical AB (Publ) The Board Of ...
(Date:3/22/2017)... Corp. (NASDAQ: DRIO), a leading global digital health ... today reported financial and operational results for the ... 2016. 2016 Highlights ... to the full year 2015  ... Direct-to-consumer model launched in U.S. ...
Breaking Medicine Technology: