Navigation Links
Human stem cells from fat tissue fuse with rat heart cells and beat
Date:2/28/2011

If Dr. Doolittle is famous for talking to animals, then here's a story that might make him hold his tongue: According to new research published online in The FASEB Journal (http://www.fasebj.org), scientists have successfully fused human stem cells derived from subcutaneous adipose (fat) tissue with muscle cells from rat hearts. Not only did these cells "talk" to form new muscle cells altogether, but they actually beat.

"Recovery of regenerative cells located in the stromal vascular fraction of a patient's own subcutaneous tissue is relatively simple and can be used for self-healing," said Christopher Alt, Ph.D., a researcher involved in the work from the Department of Molecular Pathology at the University of Texas in Houston. "A patient's quality of life can be improved by application of those recovered regenerative cells to the heart, as well as to bone, tendons, non-healing wounds and joints."

Using newborn rats, scientists studied the combination of rat heart muscle cells (cardiomyocytes) and human adipose (fat) stem cells derived from human subcutaneous adipose tissue. They found that the two fused and formed new heart muscle cells with several nuclei. When kept in a culture environment, these cells beat. These new cells exhibited an ability to compensate for a loss of cardiomyocytes as following a myocardial infarction, via fusion with cardiomyocytes. Furthermore, this study shows that contrary to previous findings suggesting that genetic modification of certain embryonic genes in adult stem cells is required as a prerequisite for turning into heart cells, the human stem cells used in this study were not genetically modified.

"Much work is still ahead before this method can be applied to humans, but the hope is that this technique might eventually make heart transplants unnecessary," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study not only shows the power of stem cell fusion technology, but also that cardiac regeneration is on the horizon."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. A guide star lets scientists see deep into human tissue
2. Fossil Suggests Humans Walked Upright 3 Million Years Ago
3. Rice University technology in human trials to spot cardiac disease, cancer, drug abuse
4. Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
5. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
6. Wild Hogs in Texas Pose Infection Risk to Humans
7. Researchers reveal function of novel molecule that underlies human deafness
8. Illegal use of human growth hormone common among young male weightlifters
9. Like humans, amoebae pack a lunch before they travel
10. Speaker series highlights the role of animals in human culture
11. Obesity in horses could be as high as in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... Boston,MA (PRWEB) , ... February 19, 2017 , ... ... software solutions for connected home healthcare, will join forces with Healthwise ® ... and education. Healthwise, the industry leader in evidence-based health education, technology and ...
(Date:2/18/2017)... ... February 17, 2017 , ... Butler Mobility invited Ken Matthews ... and other Butler products. Ken was impressed with the safety and reliability of ... the product on his show. This endorsement by Ken Matthews can be heard ...
(Date:2/18/2017)... ... February 18, 2017 , ... ProParagraph Fashion Volume ... Studios ’ ProParagraph Fashion Volume 2 for all multi-line FCPX project needs. ... can pick and choose from hand-crafted trend-setting designs with smooth animations that will ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... kept pace. Enovate Medical has introduced an innovative workstation designed to reduce nursing ... nurses, the Encore Mobile EHR Workstation offers a lightweight, highly mobile, multi-functional alternative ...
(Date:2/17/2017)... ... February 17, 2017 , ... For the first time, ... to the exhibit floor for the 2017 HIMSS Conference & Exhibition ... 19–23, 2017, more than 40,000 healthcare industry professionals are expected at the conference, ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... --  Orion Health ™ announced today the ... to the Amazon Web Services, Inc. (AWS) Cloud. ... records globally. "We are impressed by Orion ... on modern, scalable technology," said Steve Halliwell , ... Cloud gives healthcare companies a powerful tool to enable ...
(Date:2/20/2017)... , Feb. 20, 2017  Today from HIMSS17, ... image management suite, announced the launch of  Ambra ... medical imaging. Built around modern, RESTful web-services, this is ... imaging. With these new APIs, IT departments ... and imaging data into other applications such as population ...
(Date:2/20/2017)... Research and Markets has announced the ... to 2022" report to their offering. ... An increasing number ... rising adoption of tension free repair procedures and increasing demand ... repair devices global market. However, Inconsistent reimbursement and the high ...
Breaking Medicine Technology: