Navigation Links
Human stem cells from fat tissue fuse with rat heart cells and beat
Date:2/28/2011

If Dr. Doolittle is famous for talking to animals, then here's a story that might make him hold his tongue: According to new research published online in The FASEB Journal (http://www.fasebj.org), scientists have successfully fused human stem cells derived from subcutaneous adipose (fat) tissue with muscle cells from rat hearts. Not only did these cells "talk" to form new muscle cells altogether, but they actually beat.

"Recovery of regenerative cells located in the stromal vascular fraction of a patient's own subcutaneous tissue is relatively simple and can be used for self-healing," said Christopher Alt, Ph.D., a researcher involved in the work from the Department of Molecular Pathology at the University of Texas in Houston. "A patient's quality of life can be improved by application of those recovered regenerative cells to the heart, as well as to bone, tendons, non-healing wounds and joints."

Using newborn rats, scientists studied the combination of rat heart muscle cells (cardiomyocytes) and human adipose (fat) stem cells derived from human subcutaneous adipose tissue. They found that the two fused and formed new heart muscle cells with several nuclei. When kept in a culture environment, these cells beat. These new cells exhibited an ability to compensate for a loss of cardiomyocytes as following a myocardial infarction, via fusion with cardiomyocytes. Furthermore, this study shows that contrary to previous findings suggesting that genetic modification of certain embryonic genes in adult stem cells is required as a prerequisite for turning into heart cells, the human stem cells used in this study were not genetically modified.

"Much work is still ahead before this method can be applied to humans, but the hope is that this technique might eventually make heart transplants unnecessary," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study not only shows the power of stem cell fusion technology, but also that cardiac regeneration is on the horizon."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. A guide star lets scientists see deep into human tissue
2. Fossil Suggests Humans Walked Upright 3 Million Years Ago
3. Rice University technology in human trials to spot cardiac disease, cancer, drug abuse
4. Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
5. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
6. Wild Hogs in Texas Pose Infection Risk to Humans
7. Researchers reveal function of novel molecule that underlies human deafness
8. Illegal use of human growth hormone common among young male weightlifters
9. Like humans, amoebae pack a lunch before they travel
10. Speaker series highlights the role of animals in human culture
11. Obesity in horses could be as high as in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... ... at the 2016 Anti-Aging & Beauty Awards at The Aesthetic & Anti-aging ... Anti-aging Medicine European Congress (AMEC) brings together the industry’s leading scientific experts, ...
(Date:12/5/2016)... Columbus, OH (PRWEB) , ... December 05, 2016 ... ... novel engineering solution called the CardioQuick Patch® significantly improves the reproducibility and accuracy ... usability in various healthcare settings. , Over the last 60 years, studies ...
(Date:12/4/2016)... York, NY (PRWEB) , ... December 03, 2016 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – hosted its first Swirl: A Wine Tasting Event in New York ...
(Date:12/4/2016)... ... December 03, 2016 , ... While James Earl Jones is known ... for in a show called "Front Page". One of the forthcoming episodes examines mammogram ... rates have plummeted in large part due to early detection. Like any other disease, ...
(Date:12/4/2016)... ... December 03, 2016 , ... ... Entrepreneurial Company in the Dallas area” Tuesday evening at the 26th Annual SMU ... presented by SMU's Cox School’s Caruth Institute for Entrepreneurship. Dallas 100™, co-founded by ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... 2016   Pairnomix, LLC, a genetic research company ... by the White House, today announced that findings from its ... of candidate therapies for a patient with epileptic encephalopathy caused ... presented at the 70 th Annual Meeting of the ... , December 2-6, 2016.  Pairnomix, unique process ...
(Date:12/4/2016)... , Dec. 3, 2016  Findings from ... safety of CTL019, an investigational chimeric antigen receptor ... pediatric and young adult patients with B-cell acute ... an oral session at the 58th American Society ... 3, 4:00-5:30 p.m.). The global Phase II study ...
(Date:12/2/2016)... British Columbia , December 2, 2016 bioLytical Laboratories, ... de la Compañía, el INSTI HIV Self Test , a los miembros ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) ...
Breaking Medicine Technology: