Navigation Links
Human stem cells from fat tissue fuse with rat heart cells and beat
Date:2/28/2011

If Dr. Doolittle is famous for talking to animals, then here's a story that might make him hold his tongue: According to new research published online in The FASEB Journal (http://www.fasebj.org), scientists have successfully fused human stem cells derived from subcutaneous adipose (fat) tissue with muscle cells from rat hearts. Not only did these cells "talk" to form new muscle cells altogether, but they actually beat.

"Recovery of regenerative cells located in the stromal vascular fraction of a patient's own subcutaneous tissue is relatively simple and can be used for self-healing," said Christopher Alt, Ph.D., a researcher involved in the work from the Department of Molecular Pathology at the University of Texas in Houston. "A patient's quality of life can be improved by application of those recovered regenerative cells to the heart, as well as to bone, tendons, non-healing wounds and joints."

Using newborn rats, scientists studied the combination of rat heart muscle cells (cardiomyocytes) and human adipose (fat) stem cells derived from human subcutaneous adipose tissue. They found that the two fused and formed new heart muscle cells with several nuclei. When kept in a culture environment, these cells beat. These new cells exhibited an ability to compensate for a loss of cardiomyocytes as following a myocardial infarction, via fusion with cardiomyocytes. Furthermore, this study shows that contrary to previous findings suggesting that genetic modification of certain embryonic genes in adult stem cells is required as a prerequisite for turning into heart cells, the human stem cells used in this study were not genetically modified.

"Much work is still ahead before this method can be applied to humans, but the hope is that this technique might eventually make heart transplants unnecessary," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study not only shows the power of stem cell fusion technology, but also that cardiac regeneration is on the horizon."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. A guide star lets scientists see deep into human tissue
2. Fossil Suggests Humans Walked Upright 3 Million Years Ago
3. Rice University technology in human trials to spot cardiac disease, cancer, drug abuse
4. Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
5. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
6. Wild Hogs in Texas Pose Infection Risk to Humans
7. Researchers reveal function of novel molecule that underlies human deafness
8. Illegal use of human growth hormone common among young male weightlifters
9. Like humans, amoebae pack a lunch before they travel
10. Speaker series highlights the role of animals in human culture
11. Obesity in horses could be as high as in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... California (PRWEB) , ... August 16, 2017 , ... An August 3rd article ... was the subject of a report in JAMA (the Journal of the American Medical Association). ... 50 were able to achieve BMIs under 30, when compared to patients with lower BMIs. ...
(Date:8/16/2017)... ... 16, 2017 , ... For the second year, the Brain ... educate the public on the impact of concussions. Brooke Mills, student and founder ... Awareness Day. , Brooke is working diligently is to raise awareness of concussion ...
(Date:8/16/2017)... Island, NY (PRWEB) , ... August 16, 2017 , ... ... with IV starts and blood draws. By broadly deploying AccuVein devices, Maury Regional Medical ... takes much of the guesswork out of a needle stick and more importantly, helps ...
(Date:8/16/2017)... YORK, NY (PRWEB) , ... August 16, 2017 , ... ... for better treatments and ultimately, a cure. , The grants are awarded through ... comprised of scientists with a wide array of backgrounds and expertise in all areas ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... eBook, 9781498499620    ) shares that during the time of a cancer diagnosis, surgery and ... God's love, and all the many ways God shows love to those who ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... Tenn. , July 31, 2017 Three Tru-D SmartUVC ... Yongsan, South Korea . Tru-D, short for "Total Room ... and operating rooms after an environmental services (ES) professional cleans the area ... ... "Although the ...
(Date:7/28/2017)... 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... ended June 30, 2017, and updated its financial outlook ... For the fiscal third quarter, Hill-Rom reported earnings ... diluted share in the prior-year period. These results reflect ... diluted share primarily related to the non-cash write-down of ...
(Date:7/27/2017)... WARSAW, Ind., July 27, 2017  Zimmer Biomet Holdings, ... the quarter ended June 30, 2017.  The Company reported ... of 1.1% over the prior year period, and an ... approximately 240 basis points of contribution from the LDR ... from the second quarter of 2016, or 0.3% on ...
Breaking Medicine Technology: