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Human papillomavirus genotype distribution in New Mexico cervical cancers
Date:3/24/2009

d in a U.S. population," the authors write. "This study of HPV genotypes in New Mexico provides important baseline data for evaluating the effectiveness of newly implemented HPV-based technologies, HPV vaccines, and HPV screening in the prevention of cervical cancer. Moreover, these data can guide the future application of these technologies to maximize the cost-effective, public health benefits of these interventions."

The newly approved HPV vaccine protects against infections due to HPV16 and HPV18, which are associated with an earlier cancer diagnosis than other HPV genotypes. The authors suggest, therefore, that cervical cancer screening might safely be delayed, once the vaccine is more widely used, until women reach the age of 25. This possibility is further supported by the fact that very few women under age of 25 are diagnosed with cervical cancer.

In an accompanying editorial, Lauri E. Markowitz, M.D., of the Centers for Disease Control and Prevention in Atlanta, and colleagues describe some of the challenges the scientific and public health communities face in evaluating the impact of HPV vaccines. They also discuss issues related to cervical cancer screening and changing screening guidelines for vaccinated populations.

The work by Wheeler and colleagues provides important baseline data and raises numerous issues that must be considered, according to the editorialists. They conclude that "continued work is needed to determine the best methods for monitoring vaccine impact and optimal strategies for both primary and secondary prevention of cervical cancer."


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Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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