Navigation Links
Human neural stem cells restore motor function in mice with chronic spinal cord injury
Date:8/19/2010

Irvine, Calif., Aug. 19, 2010 A UC Irvine study is the first to demonstrate that human neural stem cells can restore mobility in cases of chronic spinal cord injury, suggesting the prospect of treating a much broader population of patients.

Previous breakthrough stem cell studies have focused on the acute, or early, phase of spinal cord injury, a period of up to a few weeks after the initial trauma when drug treatments can lead to some functional recovery.

The UCI study, led by Aileen Anderson and Brian Cummings of the Sue & Bill Gross Stem Cell Research Center, is significant because the therapy can restore mobility during the later chronic phase, the period after spinal cord injury in which inflammation has stabilized and recovery has reached a plateau. There are no drug treatments to help restore function in such cases.

The study appears in the open-access, peer-reviewed journal PLoS ONE and is available online at http://dx.plos.org/10.1371/journal.pone.0012272.

The Anderson-Cummings team transplanted human neural stem cells into mice 30 days after a spinal cord injury caused hind-limb paralysis. The cells then differentiated into neural tissue cells, such as oligodendrocytes and early neurons, and migrated to spinal cord injury sites. Three months after initial treatment, the mice demonstrated significant and persistent recovery of walking ability in two separate tests of motor function when compared to control groups.

"Human neural stem cells are a novel therapeutic approach that holds much promise for spinal cord injury," said Anderson, associate professor of physical medicine & rehabilitation and anatomy & neurobiology at UCI. "This study builds on the extensive work we previously published in the acute phase of injury and offers additional hope to those who are paralyzed or have impaired motor function."

"About 1.3 million individuals in the U.S. are living with chronic spinal cord injury," added Cummings, associate professor of physical medicine & rehabilitation and anatomy & neurobiology. "This latest study provides additional evidence that human neural stem cells may be a viable treatment approach for them."

The research is the latest in a series of collaborative studies conducted since 2002 with StemCells Inc. that have focused on the use of StemCells' human neural stem cells in spinal cord injury and resulted in multiple co-authored publications. StemCells Inc., based in Palo Alto, Calif., is engaged in the research, development and commercialization of stem cell therapeutics and tools for use in stem cell-based research and drug discovery.

According to Dr. Stephen Huhn, vice president and head of the central nervous system program at StemCells Inc., "the strong preclinical data we have accumulated to date will enable our transition to a clinical trial, which we plan to initiate in 2011."


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Input-output trade-offs found in human information processing
2. Human Meds Are Pets Biggest Poisoning Danger
3. NIH launches effort to define markers of human immune responses
4. New human adenovirus may not make for good vaccines, after all
5. Human clinical trial of NIH-developed dengue vaccine begins
6. Human embryonic stem cells purified in new, rapid technique
7. Scientists develop the first model for investigating the origins of testicular cancer in humans
8. Scientists unravel human-ecosystem interactions
9. UCLA scientists for the first time identify a cell-of-origin for human prostate cancer
10. Plant compound resveratrol shown to suppresses inflammation, free radicals in humans
11. Non-human sugar in biotech drugs causes inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... ... March 27, 2017 , ... Buzzies parent company, The TouchPoint Solution’s ... the Runway Foundation and UBS’ Project Entrepreneur. Mayo will present her pitch about the ... , Project Entrepreneur’s second annual venture competition ignites bold ideas by providing women access ...
(Date:3/27/2017)... , ... March 27, 2017 , ... The Case Management ... of Directors on June 30, 2017. CMSA’s membership has elected their upcoming President-Elect, ... our current Military Advisory position, a new VA Advisory position has also been added ...
(Date:3/27/2017)... Birmingham, Clarkston, and Lake Orion, Michigan (PRWEB) , ... ... ... can affect weight loss results. The comprehensive weight management program at Women’s ... begins with an initial evaluation and physical exam. The specialists at ...
(Date:3/27/2017)... ... March 27, 2017 , ... Kwalu, a leading provider of ... row; they are the recipient of the prestigious “Best Overall Design Strategy in ... at Design Connections 2017. Top A&D professionals from leading firms, furniture manufacturers and ...
(Date:3/27/2017)... ... March 27, 2017 , ... According to the American Cancer Society , ... more than 95%. Once the cancer spreads to other organs, bones, or lymph nodes, ... how to avoid this latter group, tune in to Lifestyle Magazine on ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... , March 27, 2017 BioLineRx ... and immunology, announced today that AGI-134, an immunotherapy for the ... of Agalimmune Ltd., will be featured at the upcoming ... Washington, DC to be held on ... ...
(Date:3/27/2017)... March 27, 2017  BERG, a biopharmaceutical ... biological research approach, today announced that the ... discovery of new data using a cold-induced ... fat metabolism. Joslin Diabetes Center led the ... platform for analysis of samples.  The findings ...
(Date:3/27/2017)... and BOSTON , ... a leading global pharmaceutical company and Paratek Pharmaceuticals, ... the development and commercialization of innovative therapies based ... 3 trials of sarecycline for the treatment of ... primary efficacy endpoints. Sarecycline is a once-daily, oral, ...
Breaking Medicine Technology: