Navigation Links
Human model of Huntington's disease created from skin's stem cells
Date:6/28/2012

Irvine, Calif., June 28, 2012 An international consortium of Huntington's disease experts, including several from the Sue & Bill Gross Stem Cell Research Center at UC Irvine, has generated a human model of the deadly inherited disorder directly from the skin cells of affected patients.

The re-created neurons, which live in a petri dish, will help researchers better understand what disables and kills brain cells in people with HD and let them gauge the effects of potential drug therapies on cells that are otherwise locked deep in the brain.

UCI scientists were part of a consortium that in 1993 identified the autosomal dominant gene mutation responsible for HD, but there is still no cure, and no treatments are available to even slow its onset or progression. The research, published online today in the journal Cell Stem Cell, is the work of the Huntington's Disease iPSC Consortium. Participants examined several other cell lines and control cell lines to ensure that their results were consistent and reproducible in different labs.

"Our discovery will enable us for the first time to test therapies on human Huntington's disease neurons," said Leslie Thompson, UCI professor of psychiatry & human behavior and neurobiology & behavior, one of the world's leading HD experts and a senior author of the study. "This has been a remarkable time in HD research, with the advent of stem cell technologies that have allowed these scientific advancements. Also, having a team of scientists working together as a consortium has benefited the research tremendously and accelerated its pace."

Leslie Lock, a UCI assistant professor of developmental & cell biology and biological chemistry whose lab helped develop the induced pluripotent stem cells (iPSC), added: "It's exciting to be carrying out work that provides hope for HD patients and their families."

Thompson said that UCI scientists will use the new model to study the specific gen
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fossilized Teeth Hold Clues to Early Human Species Diet
2. Human factors researcher pushes for safer gas fireplaces
3. Moving 3D computer model of key human protein is powerful new tool in fight against cancer
4. NOVAtime Solutions to be showcased at Booth #1821 in the upcoming Society for Human Resource Management (SHRM) Annual Conference and Exposition
5. Fish shed light on human melanoma
6. Anti-cocaine vaccine described in Human Gene Therapy Journal
7. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
8. Scientists Probe Diversity of Human Bodys Microbes
9. Bonobo Genome Sheds Light on Their Links to Chimps, Humans
10. Entire Genome of Human Fetus Deciphered
11. New molecular structure offers first picture of a protein family vital to human health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... 2015 Today is International Ear Care ... the occasion to applaud and promote the launch of ... Health Organization (WHO) for stemming the threat of noise-induced ... young people to practice safe listening when they recreate, ... or sporting events, or engaging in other forms of ...
(Date:3/3/2015)... March 03, 2015 The Calistoga Chamber of ... of All Weekends,” taking place Friday, March 27, through Sunday, ... Pretty Muddy 5K fun run, restaurant and bar crawl, lodging ... open to women, ages 14 and older. , A variety ... getting in on the action by offering Mudder of All ...
(Date:3/3/2015)... 03, 2015 In a segment ... science correspondent Shankar Vedantam shared research ... the drastic decrease in hand-hygiene compliance that occurs over the ... problem could be solved in part by alerts on healthcare ... they enter and exit a patient’s room. , “Over ...
(Date:3/3/2015)... OncLive® and Indiana University Melvin ... to share news about the center’s research and ... part of OncLive’s Strategic Alliance Partnership initiative. ... marketing teams will partner with the IU Simon ... to highlight accomplishments. They include the center’s recent ...
(Date:3/3/2015)... March 03, 2015 eMedEvents, a ... continuing medical education (CME) credit information, has officially ... doctors was initially launched in the United States ... its kind in the field of healthcare conference ... of this Denver, Colorado-based start-up company was successful ...
Breaking Medicine News(10 mins):Health News:ASHA Applauds Launch of New WHO Campaign 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 3Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 2Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 3Health News:IU Simon Cancer Center Teams with OncLive® in Strategic Alliance Partnership 2Health News:IU Simon Cancer Center Teams with OncLive® in Strategic Alliance Partnership 3Health News:eMedEvents Launches Online Medical Conference, Speaker and CME Platform in India 2
... -- Approximately one in three U.S. adults between the ... for colorectal cancer have not been, according to the ... Cancer Awareness Month kicks off, the society is reminding ... to screen for colorectal cancer, which is largely preventable, ...
... HealthDay Reporter , FRIDAY, March 2 (HealthDay News) -- ... demands of their own biology, women are more likely than ... see insomnia much more frequently in women, probably at least ... an assistant professor of neurology at the University of Texas ...
... In an emergency, minutes matter. With this knowledge, ... determining where emergency vehicle stations should be located. The ... for the 200 million Americans who dial 911 each ... "If we can meet this critical time window [of ...
... slowly break over time due to the pressure from ordinary ... breaks chemical bonds and produces free radicals: ions with unpaired ... aging, DNA damage and cancer in the human body. ... polymers and free radicals in a search for new energy ...
... FRIDAY, March 2 (HealthDay News) -- Researchers report they ... cell patients are most likely to experience the most severe ... at its worst, patients can suffer intense pain, internal ... people worldwide are thought to have the disease, which is ...
... Newly proposed asthma outcome measures will help standardize and ... the National Institutes of Health (NIH) spends annually to ... Inc. (MCAN), the nation,s only organization focused solely on ... led to groundbreaking improvements in better understanding and managing ...
Cached Medicine News:Health News:Too Many Americans Skipping Colon Cancer Screening 2Health News:For Sleep Struggles, Women Urged to Alter Routines 2Health News:For Sleep Struggles, Women Urged to Alter Routines 3Health News:For Sleep Struggles, Women Urged to Alter Routines 4Health News:GIS siting of emergency vehicles improves response time 2Health News:Energy squeeze 2Health News:Energy squeeze 3Health News:Sickle Cell Blood Test Might Predict Severity of Disease 2Health News:NIH asthma outcome measures aim to maximize research investments, reduce disparities 2Health News:NIH asthma outcome measures aim to maximize research investments, reduce disparities 3
(Date:3/3/2015)... 3, 2015 /CNW/ - The issue: ... product being injected at Art Nails Ltd., located at 751 Helmcken ... unauthorized as it contained no labelling. All products administered by injection ... Canada and must have approved labelling. The ... to consumers. Potential risks associated with injecting an unauthorized version of ...
(Date:3/3/2015)... -- UnaliWear announces the market preview of its first wearable ... against wandering and provides support for falls and medication ... Kanega watch ( http://www.UnaliWear.com ) – is also the ... interface rather than buttons, use cellular and Wi-Fi technology, ... The watch goes wherever the wearer goes 24/7, ...
(Date:3/3/2015)... N.J. , March 3, 2015 Konica ... USA announced today a new, integrated portable ... portable solution is now available with a larger integrated ... console mounted system offers a larger viewing area to ... now provides additional space for accessories and storage, along ...
Breaking Medicine Technology:Advisory - Health product seized from Art Nails in Vancouver 2UnaliWear's Wearable For Seniors Extends Independence With Advanced Technology 2Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 2Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 3
... The Global Genes Project ( www.globalgenesproject.org ), ... awareness about the prevalence of rare diseases worldwide, ... The 7,000 Bracelets for Hope™ campaign is designed ... chronic, life-threatening and fatal rare diseases and disorders ...
... SEATTLE, Nov. 1, 2010 Cell Therapeutics, Inc. ... it has submitted a Marketing Authorization Application ("MAA") ... (pixantrone dimaleate) as monotherapy for the treatment of ... non-Hodgkin,s lymphoma ("NHL"). The application submission follows a ...
Cached Medicine Technology:7,000 Bracelets For Hope™ - A Rare Disease Awareness Campaign 27,000 Bracelets For Hope™ - A Rare Disease Awareness Campaign 3Cell Therapeutics, Inc. (CTI) Submits European Marketing Authorization Application for Pixuvri® 2Cell Therapeutics, Inc. (CTI) Submits European Marketing Authorization Application for Pixuvri® 3
Sealing Mat for 96-well PCR Plate, Natural...
... unit, these new pads may be used in applications ... may be sealed with the same pad. The Moto ... sticking to the block and lid, and Microseal P+ ... means you can use as little as 50% of ...
Microseal 'M' mats, seals 96-well plates, reusable, pkg of 10...
An alternative sealing method for samples that are stored in 96-well plates after PCR. The mat is fully autoclavable and can be reused up to 50 times....
Medicine Products: