Navigation Links
Human clinical trial of NIH-developed dengue vaccine begins
Date:8/9/2010

e combinations of the four monovalent vaccines.

In this Phase I trial, study volunteers who have never been exposed to dengue were randomly assigned to receive one of the candidate tetravalent vaccine formulations or a placebo. http://clinicaltrials.gov/ct2/show/NCT01072786?term=dengue&state1=NA%3AUS%3AMD&rank=11. The candidate vaccines are live-attenuated, or created by making the live virus harmless or less virulent.

Evaluation of a second candidate combination vaccine has been initiated at the University of Vermont in Burlington, and trials of the third candidate will begin shortly thereafter at Johns Hopkins. These early clinical trials are designed to test the vaccine's safety and ability to stimulate immune responses in healthy adults ages 18 to 50. After a baseline assessment, participants will receive one dose of the assigned vaccine or placebo. At follow-up study visits over the next six months, the researchers will assess their health and dengue symptoms and collect blood and urine samples for analysis. After determining which tetravalent vaccine is most promising, the researchers will test that candidate in a trial in a new group of volunteers in Brazil, where dengue has become highly prevalent.

The next stage of testing, a Phase II trial, will involve more participants and will test for differences in preliminary signs of effectiveness between people who have been exposed to dengue and those who have not, as well as the need for a booster shot within a few months of the initial vaccination. "If everything goes well after that stage, we hope to start the final phase of human testing in three to four years," says Dr. Durbin.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Actor and Humanitarian Harrison Ford Assists Operation Smiles Relief Efforts in Haiti
2. Human Dental Technology Leads to Breakthroughs for Pet Dental Health at Sergeants Pet Care Products, Inc.
3. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
4. New drug for kidney transplant recipients effective in humans
5. Agility Consulting Partners with pan (Performance Assessment Network) to Bring Custom Private Label Assessment Capability to Human Resource Professionals and Consultants
6. Dolphins health shed light on human and ocean health
7. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
8. Dolphins May Warn of Health Risks in Humans
9. Inadequate access to opioid-based pain relief is a human rights issue for cancer patients
10. Sociologist expands US conversation on human rights
11. State of Oregon Department of Human Services Selects Netsmart Technologies for Comprehensive Behavioral Healthcare Integration Project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... cancer is the leading cause of cancer death in ... so many medical professionals encourage women to get mammograms, ... a minority of suspicious mammograms actually leads to a ... worry for women and their familiesnot to mention the ... and biopsies. , Recently, a different type of ...
(Date:9/30/2014)... Dynamic health trends, changing consumer ... the Bread Production industry over the past five ... their consumption of a variety of industry goods ... the market for white loaf bread and other ... introducing more nutritious products to attract health-conscious consumers, ...
(Date:9/30/2014)... Maryland-led research team has been awarded a three-year ... Health (NIH) to develop new imaging technologies and ... of how large networks of neurons in the ... will help researchers identify the precise interactions between ... decision-making and speaking, and alterations in these interactions ...
(Date:9/30/2014)... 2014 The American Diabetes Association ... diabetics curb their sweet tooth, but the most recent ... September, suggests that zero-calorie sweeteners may actually be linked ... , The Weizmann Institute of Science in Israel ... to mice, the mice developed glucose intolerance. They then ...
(Date:9/30/2014)... Regenerative Medicine Solutions (RMS) is set ... Nashville, Tennessee. RMS welcomes the launch of an entirely ... of a new treatment center for the Lung Institute. ... Institute to Nashville, the hope is to bring awareness ... diagnosed and undiagnosed. With Nashville being a hub for ...
Breaking Medicine News(10 mins):Health News:'Virtual breast' could improve cancer detection 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:UMD receives inaugural BRAIN Initiative Award 2Health News:Artificial Sweeteners May be Linked to Greater Diabetes Risk 2Health News:Regenerative Medicine Solutions Expanding 2
... 2010Announcing the launch of the Liebert Mobile iPhone ... news, resources, press releases, research, and multimedia content ... across the biomedical, biotechnology, medicine, surgery, and nursing, ... available with this free application. Updated ...
... Addicts ... ... economic times like these many students are postponing or quitting their educational pursuits for financial ... addict these challenges are not only real but exacerbated due to their personal fight. Today, ...
... while 87% of younger patients got it after surgery , ... are less likely than younger ones to receive potentially life-prolonging ... , The research indicates that those with advanced colon cancer ... likely to receive chemotherapy and more likely to receive less ...
... in the signature bracelet -- that they give to supporters when they make a minimum $15.00 donation -- they immediately took action.  The ... ... , ... ...
... to be associated with more appropriate follow-up and shorter ... an abnormal result on a mammogram, according to a ... of Internal Medicine , one of the JAMA/Archives journals. ... for Research on Inner City Health, St. Michael,s Hospital, ...
... News media, scientists and others interested in finance, entrepreneurship ... American Chemical Society (ACS) Small & Medium Business Webinar ... with subject matter experts and global thought leaders in ... of interest to scientific and engineering professionals. Each ...
Cached Medicine News:Health News:Academy's Community Initiative Offers Qualifying Former Addicts Free Vocational Training 2Health News:Older Colon Cancer Patients Less Likely to Get Chemo 2Health News:Older Colon Cancer Patients Less Likely to Get Chemo 3Health News:Older Colon Cancer Patients Less Likely to Get Chemo 4Health News:An Update on Mel's Bracelet 2
(Date:9/30/2014)... , Sept. 30, 2014 The Eastern European ... established medical-device providers as well as new medical-device manufacturers ... while simultaneously looking at ways to reduce the cost ... distributors is one of the effective means to achieve ... distribution market in Eastern European and provides profiles of ...
(Date:9/30/2014)... , Sept. 30, 2014   Decision Resources ... claims data, anemic chronic kidney disease non-dialysis (CKD-ND) ... agent (ESA) medication. In addition, one-year persistency is ... Other key findings from the report ... Analysis of Erythropoiesis Stimulating Agents in Late Stage ...
(Date:9/30/2014)... Calif. , Sept. 30, 2014  Arena ... (PLM) applications, today announced its Fall 2014 release, ... Scribe and Arena DataExtract – ... The newly available products are focused specifically on ... and the aggregation of a complete history of ...
Breaking Medicine Technology:Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3Persistency is Low for Late-Stage Anemic CKD Non-Dialysis Patients Treated with Erythropoiesis-Stimulating Agents 2Persistency is Low for Late-Stage Anemic CKD Non-Dialysis Patients Treated with Erythropoiesis-Stimulating Agents 3Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 2Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 3Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 4
... The Eppendorf Reference Series 2000 Pipette ... smooth stroke, a compact and robust design, ... button is used to operate the measuring ... the tip. Product features:Eppendorf "pipette/tip" system ensures ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
... Focus from Thermo Labsystems was ... with uncompromising performance. The ... a custom fit for different ... tip cones allow easier and ...
... The Eppendorf Reference Series 2000 Pipette ... smooth stroke, a compact and robust design, ... button is used to operate the measuring ... the tip. Product features:Eppendorf "pipette/tip" system ensures ...
Medicine Products: