Navigation Links
Human breast tumors' 'microenvironment' primes them for metastasis
Date:4/3/2008

The environment within primary breast tumors can empower cells that break free and enter the bloodstream to successfully invade other organs, researchers report in the April 4th Cell, a publication of Cell Press.

Specifically, through studies of hundreds of human breast tumors, the researchers found evidence that the cytokine TGF in the tumor microenvironment primes breast cancer cells for metastasis to the lungs, one of the most common sites for the spread of breast and other cancers. TGF signaling is often activated within tumors as a natural response to the oxygen starved and inflammatory conditions that come with tumor progression.

The microenvironment of a tumor is not just cancer cells, but all other cell types that congregate there, said Joan Massague of Memorial Sloan-Kettering Cancer Center in New York. In recent years, he said, increasing attention has been paid to the impact those other body cells can have on the tumor locally, through their affects on blood vessel growth, the ability of cancer cells to enter the circulation, and so on.

Our study shows that it doesnt end there, he said. The cancer cells can come out with instructions that serve them in the long run.

The research team analyzed the expresssion of all 20,000 genes in the human genome within hundreds of primary breast tumors. Those tumors fell within two classical groups based on whether their estrogen receptor status was positive or negative (ER+ or ER-). In both tumor groups, the researchers found that about 40 percent of the tumors bore the genetic signature of TGF?s influence.

They found that TGF exposure didnt seem to make any difference to the risk of cancer spread in ER+ tumors. In ER- tumors, however, TGF correlated markedly with an increased risk for metastasis to the lung, but not to bone. In other words, Massague said, context matters."

The researchers continued to dig, ultimately uncovering the fascinating biology behind that correlation. They found that the TGF exposure in ER- tumors leads to an increase in a second cytokine within the tumor cells, called angiopoietin-like 4 (ANGPTL4). Once those cells escape the tumor and lodge in the lungs, ANGPTL4 disrupts the connections between cells in the thin capillaries there. That separation of cell-cell contacts allows the cancer cells to cross the vessel wall and pass into the lung proper, Massague said.

The findings suggest that TGF, or perhaps even better ANGPTL4, might serve as targets for drugs aimed at preventing the spread of breast cancer to the lungs. The TGF signature could also offer a means of predicting those breast cancer patients at particularly high risk for developing metastatic lung cancer so that they might be monitored more closely and treated more aggressively with existing drugs.

Massague said he suspects the new findings are but one example of a more general cancer phenomenon.

Entering and colonizing an organ requires of a tumor cell a number of special abilities, he said. After all, our bodies are not made up of cells that are allowed to go anywhere as tumor cells [sometimes] manage to do. Weve shown that factors within primary tumors can act on cancer cells to enhance their ability to selectively spread to other tissues.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. General Dynamics Itronix Donates Computers to Humanitarian Expedition Fighting Malaria in Africa
2. Families of children with cancer support human tissue research, study finds
3. Mayo Clinic Proceedings Examines a Possible Link Between Bacteria Found in the Human Digestive System and Obesity
4. Humans have more distinctive hearing than animals, Hebrew U study shows
5. Dogs and Cats Need Omega-3 Fatty Acids Just as Humans Do - Nordic Naturals Offers Premium Fish Oil to Supplement Pets Diet!
6. UCLA researchers examine human embryonic stem cell genome
7. 10th Annual Human Resources Conference, June 4-6: Sharing New Insights on Workforce Planning
8. Batesville Holdings, Inc., Appoints Doug Wilson Senior Vice President Human Resources
9. Researchers urge ethics guidelines for human-genome research
10. Source Endurance and So High Sports Announce Research Alliance for Physiology and Human Performance
11. Monkey Brain Gives Clues to Human Interaction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: