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Human aging gene found in flies
Date:5/11/2008

flies that have the damaged version of the gene and the chromosomes are often altered. The researchers show that the flys DNA becomes rearranged, with genes being swapped between chromosomes. In patients with Werner syndrome, this genome instability leads to cancer. Cells derived from Werner syndrome patients are extremely sensitive to a drug often used to treat cancers: the researchers show that the flies that have the damaged gene are killed by even very low doses of the drug.

Professor Nigel Brown, Director of Science and Technology, Biotechnology and Biological Sciences Research Council said: The ageing population presents a major research challenge to the UK and we need effort to understand normal ageing and the characteristics that accompany it.

Fruit flies are already used as a model for the genetics behind mechanisms that underlie normal functioning of the human body and it is great news that this powerful research tool can be applied to such an important area of study into human health.


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Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

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