Navigation Links
Human Stem Cells Used to Fix Damaged Mouse Heart
Date:7/18/2011

MONDAY, July 18 (HealthDay News) -- Genetically engineered human cardiac stem cells helped repair damaged heart tissue in mice, according to a new study.

And, the researchers revealed, 10 weeks after the stem cells were implanted, tissue repair and function in these mice doubled that of control animals. They also noted the improvement lasted for at least 20 weeks.

"This study brings us one step closer to a clinical application for stem cell therapy," the study's lead author, Sadia Mohsin, post-doctoral research scholar at San Diego State University in California, said in a news release from the American Heart Association. "Since patients with heart failure are normally elderly, their cardiac stem cells aren't very healthy. We were able to modify these stem cells, obtained from heart failure patients, to be healthier so that they could be transplanted into the heart and survive and thrive."

Unlike other cells, stem cells can regenerate and have the potential to develop into multiple types of tissue. In conducting the study, the researchers used cardiac stem cells from patients receiving mechanical assist device pumps for failing hearts. The stem cells were genetically engineered to express a protein, known as Pim-1, which naturally occurs in response to heart damage.

The genetically engineered Pim-1 and non-modified human cardiac cells were implanted into the mice that had been induced to have a heart attack so researchers could compare the two groups.

Using molecular technology, the researchers also attached another fluorescent green protein derived from jellyfish so the Pim-1 was more easily identified.

The study authors concluded that the application could help in the advancement of stem cell therapy.

Commenting on the study, Dr Roger Hajjar, professor of medicine, cardiology, and professor of gene and cell medicine at Mount Sinai School of Medicine in New York City, said, "One of the main limitations of cell therapy for cardiovascular diseases has been the survival of cardiac progenitors cells implanted into the heart. In certain studies, more than 90 percent of these implanted cells die after injection into the diseased hearts, decreasing their ability to repair the hearts."

In this new study, the researchers showed that by expressing the gene Pim1, the team was "able to enhance the reparative capacity of these cells. This is an important study addressing an unmet need in the field of stem cell therapy."

While the study results are encouraging, experts note that research involving animals frequently doesn't lead to medical advances that benefit people.

More information

The U.S. National Institutes of Health provides more information on stem cells.

-- Mary Elizabeth Dallas

SOURCES: American Heart Association, news release, July 18, 2011; Roger Hajjar, MD, professor medicine, cardiology, and professor gene and cell medicine, Mount Sinai School of Medicine, New York City


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel Virus Jumped From Monkeys to Humans, Researchers Find
2. R&D collaboration focuses on new system for measuring and improving human vision
3. Covidien supports NOSCAR US multicenter human trial
4. UCSF team describes genetic basis of rare human diseases
5. HFES sponsors 2012 Symposium on Human Factors and Ergonomics in Health Care
6. Researchers identify components of speech recognition pathway in humans
7. New book shines light on French versus British models of humanitarian aid
8. Mayo Clinic researchers use human vaccine to cure prostate cancer in mice
9. Study of biomarker development in mice provides a roadmap for a similar approach in humans
10. Scientists create humanized mouse model for hepatitis C
11. Historic first images of rod photoreceptors in the living human eye
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Human Stem Cells Used to Fix Damaged Mouse Heart
(Date:2/13/2016)... ... ... DDi , a Makro company, makes it to ... in eClinical Solutions. DDi has built its solution competency with a unique blend ... DDi provides smarter technology for Clinical Development, Regulatory and Enterprise domains by providing ...
(Date:2/12/2016)... ... 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & Bassett ... of these scholarships is to encourage applicants to pursue a degree in their field ... two parishes. , “We have available jobs in St. Landry and Evangeline Parishes ...
(Date:2/12/2016)... Church, VA (PRWEB) , ... February 12, 2016 , ... CDRH Enforcement Trends: , Back ... http://www.fdanews.com/cdrhenforcementtrends , As Winston Churchill said, “Those who don’t learn from ... will show what to expect when they come knocking this year. But that takes time. ...
(Date:2/12/2016)... ... 12, 2016 , ... As a former television executive, owner Tal Rabinowitz knows ... time to decompress, Rabinowitz found herself drawn to a casual meditation class while working ... her life, implementing a 20-minute-per-day meditation practice with her team. After her tenure at ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... Leadership Series at Zuckerberg San Francisco General Hospital on April 5-7. The series ... behaviors and create new habits. The workshops cover a broad range of topics, ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Kindred Biosciences, Inc. (NASDAQ: ... and improving the lives of pets, today announced the ... the New Animal Drug Application (NADA) for Zimeta™ (dipyrone ... study (KB0120) of Zimeta for the control of pyrexia ... --> --> The ...
(Date:2/11/2016)... , Feb. 11, 2016 Potrero Medical, Inc., the ... to announce the appointment of George M. Rapier, III ... San Antonio, TX , WellMed is one of the ... patients and HMO members in Texas ... 1990 out of his own internal medicine practice, he has ...
(Date:2/11/2016)... , Feb. 11, 2016  AfterPill.com is reporting that ... alcohol abstinence for all women who are at risk ... U.S. each year and raises the risks of unprotected ... --> According to the Guttmacher Institute, there ... women of child-bearing age, who have sex without the ...
Breaking Medicine Technology: