Navigation Links
Human Stem Cells Used to Fix Damaged Mouse Heart
Date:7/18/2011

MONDAY, July 18 (HealthDay News) -- Genetically engineered human cardiac stem cells helped repair damaged heart tissue in mice, according to a new study.

And, the researchers revealed, 10 weeks after the stem cells were implanted, tissue repair and function in these mice doubled that of control animals. They also noted the improvement lasted for at least 20 weeks.

"This study brings us one step closer to a clinical application for stem cell therapy," the study's lead author, Sadia Mohsin, post-doctoral research scholar at San Diego State University in California, said in a news release from the American Heart Association. "Since patients with heart failure are normally elderly, their cardiac stem cells aren't very healthy. We were able to modify these stem cells, obtained from heart failure patients, to be healthier so that they could be transplanted into the heart and survive and thrive."

Unlike other cells, stem cells can regenerate and have the potential to develop into multiple types of tissue. In conducting the study, the researchers used cardiac stem cells from patients receiving mechanical assist device pumps for failing hearts. The stem cells were genetically engineered to express a protein, known as Pim-1, which naturally occurs in response to heart damage.

The genetically engineered Pim-1 and non-modified human cardiac cells were implanted into the mice that had been induced to have a heart attack so researchers could compare the two groups.

Using molecular technology, the researchers also attached another fluorescent green protein derived from jellyfish so the Pim-1 was more easily identified.

The study authors concluded that the application could help in the advancement of stem cell therapy.

Commenting on the study, Dr Roger Hajjar, professor of medicine, cardiology, and professor of gene and cell medicine at Mount Sinai School of Medicine in New York City, said, "One of the main limitations of cell therapy for cardiovascular diseases has been the survival of cardiac progenitors cells implanted into the heart. In certain studies, more than 90 percent of these implanted cells die after injection into the diseased hearts, decreasing their ability to repair the hearts."

In this new study, the researchers showed that by expressing the gene Pim1, the team was "able to enhance the reparative capacity of these cells. This is an important study addressing an unmet need in the field of stem cell therapy."

While the study results are encouraging, experts note that research involving animals frequently doesn't lead to medical advances that benefit people.

More information

The U.S. National Institutes of Health provides more information on stem cells.

-- Mary Elizabeth Dallas

SOURCES: American Heart Association, news release, July 18, 2011; Roger Hajjar, MD, professor medicine, cardiology, and professor gene and cell medicine, Mount Sinai School of Medicine, New York City


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel Virus Jumped From Monkeys to Humans, Researchers Find
2. R&D collaboration focuses on new system for measuring and improving human vision
3. Covidien supports NOSCAR US multicenter human trial
4. UCSF team describes genetic basis of rare human diseases
5. HFES sponsors 2012 Symposium on Human Factors and Ergonomics in Health Care
6. Researchers identify components of speech recognition pathway in humans
7. New book shines light on French versus British models of humanitarian aid
8. Mayo Clinic researchers use human vaccine to cure prostate cancer in mice
9. Study of biomarker development in mice provides a roadmap for a similar approach in humans
10. Scientists create humanized mouse model for hepatitis C
11. Historic first images of rod photoreceptors in the living human eye
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Human Stem Cells Used to Fix Damaged Mouse Heart
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... On Dec. ... the Hard Rock Hotel San Diego honoring the 2016 MPN Heroes—eight individuals who have ... (MPNs) by going above and beyond the standard of care, demonstrating leadership within the ...
(Date:12/2/2016)... ... ... Advanced Inc., a leading provider of travel therapy and travel nursing across ... Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason previously served as Vice ... leadership experience to Advanced Inc. He began his career in finance at Ernst & ...
(Date:12/2/2016)... Raleigh, NC (PRWEB) , ... December 02, 2016 , ... ... the Open Enrollment Period (or Annual Election Period), is ending December 7th. Currently-enrolled Medicare ... plan (Part C) or prescription drug plan (Part D) need to make changes during ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... interview of two ostomy patients, standing as living proof that attitude and determination ... digestive diseases and issues that spike around the holidays. This campaign will offer ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Health" in USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized ... fulfilling lives. “We are prolonging life 6 years in the last 3 decades,” ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 According to a ... by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical ... Nephrology, Infectious Diseases) - Forecast to 2021" published ... USD 60.22 Billion in 2016. This market is ... during the forecast period (2016-2021) to reach USD ...
(Date:12/2/2016)...  The Addiction Treatment Advisory Group (ATAG), created ... Pharmacy (AMCP), has released detailed findings on how ... addiction crisis, including through improved access to naloxone ... newly released paper, "The Role of Managed Care ... issues around gaps and barriers to addiction treatment ...
(Date:12/2/2016)... -- Boston Scientific Corporation (NYSE: BSX ) ... assets and capabilities of the Neovasc, Inc., (NASDAQ: ... as well as a 15% equity stake in Neovasc, ... Neovasc advanced biological tissue business makes elements used in ... System. * Upon completion of the transaction, the ...
Breaking Medicine Technology: