Navigation Links
Human Stem Cells Used to Fix Damaged Mouse Heart
Date:7/18/2011

MONDAY, July 18 (HealthDay News) -- Genetically engineered human cardiac stem cells helped repair damaged heart tissue in mice, according to a new study.

And, the researchers revealed, 10 weeks after the stem cells were implanted, tissue repair and function in these mice doubled that of control animals. They also noted the improvement lasted for at least 20 weeks.

"This study brings us one step closer to a clinical application for stem cell therapy," the study's lead author, Sadia Mohsin, post-doctoral research scholar at San Diego State University in California, said in a news release from the American Heart Association. "Since patients with heart failure are normally elderly, their cardiac stem cells aren't very healthy. We were able to modify these stem cells, obtained from heart failure patients, to be healthier so that they could be transplanted into the heart and survive and thrive."

Unlike other cells, stem cells can regenerate and have the potential to develop into multiple types of tissue. In conducting the study, the researchers used cardiac stem cells from patients receiving mechanical assist device pumps for failing hearts. The stem cells were genetically engineered to express a protein, known as Pim-1, which naturally occurs in response to heart damage.

The genetically engineered Pim-1 and non-modified human cardiac cells were implanted into the mice that had been induced to have a heart attack so researchers could compare the two groups.

Using molecular technology, the researchers also attached another fluorescent green protein derived from jellyfish so the Pim-1 was more easily identified.

The study authors concluded that the application could help in the advancement of stem cell therapy.

Commenting on the study, Dr Roger Hajjar, professor of medicine, cardiology, and professor of gene and cell medicine at Mount Sinai School of Medicine in New York City, said, "One of the main limitations of cell therapy for cardiovascular diseases has been the survival of cardiac progenitors cells implanted into the heart. In certain studies, more than 90 percent of these implanted cells die after injection into the diseased hearts, decreasing their ability to repair the hearts."

In this new study, the researchers showed that by expressing the gene Pim1, the team was "able to enhance the reparative capacity of these cells. This is an important study addressing an unmet need in the field of stem cell therapy."

While the study results are encouraging, experts note that research involving animals frequently doesn't lead to medical advances that benefit people.

More information

The U.S. National Institutes of Health provides more information on stem cells.

-- Mary Elizabeth Dallas

SOURCES: American Heart Association, news release, July 18, 2011; Roger Hajjar, MD, professor medicine, cardiology, and professor gene and cell medicine, Mount Sinai School of Medicine, New York City


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel Virus Jumped From Monkeys to Humans, Researchers Find
2. R&D collaboration focuses on new system for measuring and improving human vision
3. Covidien supports NOSCAR US multicenter human trial
4. UCSF team describes genetic basis of rare human diseases
5. HFES sponsors 2012 Symposium on Human Factors and Ergonomics in Health Care
6. Researchers identify components of speech recognition pathway in humans
7. New book shines light on French versus British models of humanitarian aid
8. Mayo Clinic researchers use human vaccine to cure prostate cancer in mice
9. Study of biomarker development in mice provides a roadmap for a similar approach in humans
10. Scientists create humanized mouse model for hepatitis C
11. Historic first images of rod photoreceptors in the living human eye
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Human Stem Cells Used to Fix Damaged Mouse Heart
(Date:1/23/2017)... ... January 23, 2017 , ... ... science companies, has achieved ISO 17100:2015 certification following a comprehensive audit performed ... the globally recognized standard that establishes guidance for critical processes within translation, ...
(Date:1/23/2017)... ... January 23, 2017 , ... Ultimate Medical Academy today ... to be held March 23-25, 2017 in Tampa, and reminded educators and education ... keynote speakers include Dr. Michelle R. Weise, executive director of the Sandbox Collaborative, ...
(Date:1/23/2017)... ... January 23, 2017 , ... DMG Productions is ... Ed Begley, Jr., scheduled to broadcast Saturday, January 28, 2017 at 5:00pmEST. , ... in 2008 to address the limitations of fatigue monitoring technologies within the mining ...
(Date:1/23/2017)... IL (PRWEB) , ... January 23, 2017 , ... ... first-quality education and high-level training standards for healthcare treatment providers who treat the ... to its Presidents Council. , The Presidents Council consists of the leading ...
(Date:1/23/2017)... ... January 23, 2017 , ... Wooden and plastic balance boards have been around since at ... Kumo Board is the first and only balance board to use a patent-pending ... and rigid at the same time as well as skill-level adjustable for all ages and ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... A new Transparency Market Research report states ... at US$0.53 bn in 2013 and is predicted to touch US$2.38 ... 2014 and 2022. The title of the report is "Non-invasive Prenatal ... Trends and Forecast 2014 - 2022." ... Non-invasive prenatal testing (NIPT), also referred to as ...
(Date:1/23/2017)... Longer life expectancy and rising healthcare expenditure in ... medical device technologies. BCC Research reveals in its new report ... region, should see strong growth due to rising government healthcare spending, ... Continue Reading ... ...
(Date:1/23/2017)... January 23, 2017 The global  anxiety disorders and depression ... 2025. The rising incidence of depression worldwide is anticipated to drive the market ... in the declining demand for antidepressants in the recent years. ... ... View Research Logo ...
Breaking Medicine Technology: