Navigation Links
Human Cells Used to Make Replacement Anal Sphincters in Mice
Date:8/10/2011

WEDNESDAY, Aug. 10 (HealthDay News) -- The first working, replacement anal sphincters have been built in a laboratory and tested on mice.

Now scientists hope the research will benefit humans with fecal and urinary incontinence, because current methods used to repair internal anal sphincters, such as skeletal muscle grafts, silicone injections or mechanical implants, have had only limited success.

"In essence, we have built a replacement sphincter that we hope can one day benefit human patients. This is the first bioengineered sphincter made with both muscle and nerve cells, making it 'pre-wired' for placement in the body," senior author Khalil N. Bitar, a professor of regenerative medicine at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine, said in a Wake Forest news release.

Scientists were able to make the bioengineered anal sphincters in about six weeks using human muscle and nerve cells. They found the sphincters were able to generate blood supply and work properly in mice.

The investigators hope their research will lead to a more effective treatment for humans because there is a high rate of weakened internal anal sphincters in older adults. Women who had episiotomies during childbirth can also be affected by this condition.

"Many individuals find themselves withdrawing from their social lives and attempting to hide the problem from their families, friends, and even their doctors," said Bitar. "Many people suffer without help."

Repeated laboratory tests of the engineered sphincters showed they functioned normally, relaxing and contracting, in the mice. The sphincters were also re-tested after a period of 25 days and compared to the mice's original sphincters. The researchers found the man-made sphincters continued to work like natural ones.

The mice chosen for the experiment had suppressed immune systems to reduce the risk of rejection of the new sphincters, the study authors pointed out. Ultimately, the scientists said they hope to use the muscle and nerve cells of individual human patients to build personalized pre-wired sphincters, eliminating the risk of rejection.

"The engineered sphincters were physiologically similar to native tissue," said Bitar. "This takes us one step closer to realizing the goal of using a patient's own cells to engineer a replacement sphincter in the lab."

The authors concluded that their research could lead to the development of treatments for other conditions. "While we have numerous challenges to meet, we have crossed a major hurdle," noted Bitar. "This proof of concept research suggests that this strategy may be useful for treating a variety of neuromuscular conditions of the intestine. In addition, it could potentially be applied to other diseases of sphincter muscles, including urinary incontinence."

The study was published in a recent issue of the journal Gastroenterology.

More information

The U.S. National Library of Medicine has more on fecal incontinence.

-- Mary Elizabeth Dallas

SOURCE: Wake Forest Baptist Medical Center, news release, Aug. 9, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Education -- a key determinant of population growth and human well-being
2. Human Brains Wired to Empathize, Study Finds
3. Dolphins Superior Ability to Heal May Help Humans
4. Ancient Footprints Reveal Earliest Signs of Human-Like Gait
5. INFORMS: CARE positions disaster relief with promising discipline of humanitarian logistics
6. INFORMS journal announces special issue on using logistics, analytics in humanitarian relief
7. Dolphins remarkable recovery from injury offers important insights for human healing
8. Genetic map of African-Americans to aid study of diseases, human evolution
9. BIDMC to co-lead NIH consortium for AIDS vaccine research in nonhuman primates
10. IBD, LCPD health research in Westie dogs may hold answers to similar human diseases
11. Human Stem Cells Used to Fix Damaged Mouse Heart
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Human Cells Used to Make Replacement Anal Sphincters in Mice 
(Date:3/23/2017)... ... ... feature 150+ Hospital and Health System Executive Speakers including: , , ... of the United States of America: George W. Bush , Boxing Legend, Successful ... Ray Leonard , JD, Chairperson, McGuireWoods LLP: Amber McGraw Walsh , ...
(Date:3/23/2017)... ... ... Sharon Kleyne, host of the nationally syndicated radio program, The Sharon Kleyne ... on her program about how she is looking forward to World Water Day on ... distinction. World Water Day, Kleyne pointed out, is an occasion for looking ahead with ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... supplements that help improve all aspects of people’s health and nutrition, announced its ... nutritional products. , Natural Subsistence develops nutritional supplements that help people improve ...
(Date:3/23/2017)... ... March 23, 2017 , ... Inflow IQ & Inflownomics of Raleigh, NC ... on a solid foundation. As experts in dangerous situations the Inflow IQ team ... soon. Inflownomics deliver ripe, fresh, clean & refreshing knowledge systems that enhance life. ...
(Date:3/23/2017)... ... March 23, 2017 , ... The American Board of Quality Assurance and ... of ABQAURP’s dedication to Health Care Quality and Management and Patient Safety. , It ... to the association, but also to the Health Care Quality and Patient Safety movements. ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... HICKORY, N.C. , March 23, 2017  Transportation ... accolades as an end-to-end supply chain management firm with ... of Consumer Product Solutions Rick Zaffarano was ... Star of the Supply Chain by the only publication ... the global food supply chain. "Rick has ...
(Date:3/23/2017)... -- Summary Global Markets ... Primary Hyperoxaluria - Pipeline Review, H1 2017, provides ... System And Sex Hormones) pipeline landscape. Primary ... kidney and bladder stones. It results from the ... blood in the urine, pain when urinating, fever, ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... ... oxygen therapy devices market to grow at a CAGR of 10.16% ... Therapy Devices Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Medicine Technology: