Navigation Links
'Hub' of fear memory formation identified in brain cells
Date:9/28/2008

A protein required for the earliest steps in embryonic development also plays a key role in solidifying fear memories in the brains of adult animals, scientists have revealed. An apparent "hub" for changes in the connections between brain cells, beta-catenin could be a potential target for drugs to enhance or interfere with memory formation.

The results are published online this week and appear in the October issue of Nature Neuroscience.

The protein beta-catenin acts like a Velcro strap, fastening cells' internal skeletons to proteins on their external membranes that connect them with other cells. In species ranging from flies to frogs to mice, it also can transmit early signals that separate an embryo into front and back or top and bottom.

During long-term memory formation, structural changes take place in the synapses the connections between neurons in the brain, says Kerry Ressler, MD, PhD, associate professor of psychiatry and behavioral sciences at Emory University School of Medicine. Ressler is a researcher at Emory University's Yerkes National Primate Research Center, where the research was conducted, and a Howard Hughes Medical Institute investigator.

"We thought beta-catenin could be a hub for the changes that take place in the synapses during memory formation," says Ressler. "But because beta-catenin is so important during development, we couldn't take the standard approach of just knocking it out genetically."

He and graduate student Kimberly Maguschak used a variety of approaches to probe beta-catenin's role in fear memory formation, such as stabilizing the protein with a pulse of the psychiatric drug lithium and injecting a virus that could remove the gene for beta-catenin from brain cells.

If mice are electrically shocked just after they hear a certain tone, they gradually learn to fear that tone, and they show that fear by freezing.

To test beta-catenin's involvement i
'/>"/>

Contact: Kathi Baker
kobaker@emory.edu
404-727-9371
Emory University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Joint NJ/NY Rally for Addiction Recovery to Be Hub of Events Nationwide
2. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
3. Federal Labor Law Violations Provoke Teamster Strike at AmerisourceBergen Northwest Distribution Hub
4. Founding CEOS of SureScripts(R) and RxHub(R) Join Forces to Deliver Clinical Information Technology Services to Physician Practices
5. Epilepsy marked by neural hub network
6. Baker Energy and Huber Receive First-of-its-Kind Award from Wyoming Department of Environmental Quality
7. AVMA Launches Animal Welfare Web Section to Provide Hub for Programs and Information
8. Chubb Expects to Release Earnings on July 24 and Hold Conference Call on the Same Day
9. HUB International New England Reminds Massachusetts Boaters that Safety is Paramount This Summer
10. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
11. Removing Ovaries Before Menopause Leads to Memory, Movement Troubles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... First Choice Emergency Room opened ... The new facility is located 1501 FM 685, Pflugerville, Texas ... to be a part of First Choice Emergency Room’s second ... deliver high quality emergency medical care to the local community,” ... Emergency Room Pflugerville – FM 685. , To ...
(Date:8/29/2014)... What is bullying and why does it matter in ... harming, mistreatment by one or more people. It takes ... It is a form of abusive conduct very much ... bullying is a wide range of misconduct, but for us, ... short of the physical, just short of battery.” , “There ...
(Date:8/29/2014)... San Diego, CA (PRWEB) August 29, 2014 ... regarding all the latest information from the FDA on ... on August 26, that several sterile convenience surgical packs, by ... of sterility. , The reason for the recall is ... lead to loss of product sterility and infection. The affected ...
(Date:8/29/2014)... The Florida Chiropractic Association held its ... last week August 21-24 and Maryland and Virginia chiropractor ... , Dr. Greenstein presented at three different ... a standing room session; (2) A Panelist at the ... Leading the Way in Injury Prevention and Maximizing Human ...
(Date:8/29/2014)... Canadian Healthy Vending , the largest ... annual survey of its 200 operators from every region ... that appeal to Canadian consumer seeking refreshment at healthy ... top five selling healthy snacks and top five selling ... issue for consumers, employers, and families. Everyone wants to ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Opens New Facility in Pflugerville, Texas 2Health News:Bullying Expert Dr. Gary Namie discusses NCAA and Professional Sports with Sports Conflict Institute 2Health News:Bullying Expert Dr. Gary Namie discusses NCAA and Professional Sports with Sports Conflict Institute 3Health News:Sterile Convenience Surgical Packs by Customed, Inc. Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Sport and Spine Rehab’s CEO Presents at the Florida Chiropractic Association National Convention and Expo 2014 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 3
... percent of food products specifically targeted to babies and ... than 20 per centof calories coming from sugar, according ... Charlene Elliott. The study, funded by the ... sugar and sodium levels in 186 food products specifically ...
... the Gulf of Mexico, and they are concerned about its potential ... from a continuing survey conducted by the University of Minnesota. ... conducted by The Food Industry Center at the U of M. ... were aware of the spill and 85 percent say they are ...
... ... needs of athletes by offering all natural custom energy bars at elementendurance.com. , ... Chicago, IL (PRWEB) June 28, 2010 -- ... athletes to build their own all-natural, custom energy bars to their training and race needs. ...
... tooth-bleaching agent may improve the oral health of elderly ... of Georgia and Western University of Health Sciences. ... be difficult or impossible for patients with mental challenges ... medications cause xerostomia, or dry mouth, the lack of ...
... the Iacocca Foundation announce today the completion of the Phase ... as the submission of all safety reports to the U.S. ... monitoring boards. Plans for the Phase II clinical study, which ... a treatment for people with existing type 1 diabetes, are ...
... June 28, 2010 In the first ever published estimate ... with their minor children, a team led by a Wake ... cancer survivors are parenting young children, highlighting a group of ... in Cancer , a peer-reviewed journal of the American ...
Cached Medicine News:Health News:Toddler foods too sweet 2Health News:Toddler foods too sweet 3Health News:Element Endurance – Custom Energy Bars for Athletes 2Health News:Tray bleaching may improve oral health of elderly, special-needs patients 2Health News:Mass. General Hospital, Iacocca Foundation announce completion of Phase I diabetes trial 2Health News:More than a million parents with minor children are cancer survivors 2
(Date:8/28/2014)... Pa. , Aug. 28, 2014  Robotic ... patients, and media, both for the promise of ... safety. The quick deployment of surgical robots and ... are prompting facilities to evaluate their robotic surgery ... entire surgical team.    ECRI Institute ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 ... new market research report is available ... Therapeutics to 2020 - Broadened Diagnostic ... Drive Market Growth despite Patent Expirations ... ADHD Therapeutics to 2020 ...
(Date:8/28/2014)... OAKS, Calif. , Aug. 28, 2014 ... submission of a Biologics License Application (BLA) to the ... approval for the treatment of high cholesterol. Evolocumab is ... convertase subtilisin/kexin type 9 (PCSK9), a protein that reduces ... or "bad" cholesterol, from the blood. 1 ...
Breaking Medicine Technology:Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 2Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 3Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 5ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 2ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 3ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 4ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 5ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 6ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 7ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 8Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 2Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 3Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 4Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 5Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 6Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 7Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 8Amgen Submits Biologics License Application For Novel Investigational LDL Cholesterol-Lowering Medication Evolocumab To The FDA 9
Jaws with fine teeth. Serrated handle with polished finish. Jaws: Wide, 4.5 mm. With thumb catch lock....
Straight shafts with curved 1 x 2 teeth. Serrated handle with polished finish....
Straight shafts, 1 x 2 teeth. Wide serrated handle with polished finish. Teeth: 0.3 mm. Most popular size or model....
Straight shafts with delicate 0.7 mm, 1 x 2 teeth. Serrated handle with polished finish....
Medicine Products: