Navigation Links
'Hub' of fear memory formation identified in brain cells
Date:9/28/2008

A protein required for the earliest steps in embryonic development also plays a key role in solidifying fear memories in the brains of adult animals, scientists have revealed. An apparent "hub" for changes in the connections between brain cells, beta-catenin could be a potential target for drugs to enhance or interfere with memory formation.

The results are published online this week and appear in the October issue of Nature Neuroscience.

The protein beta-catenin acts like a Velcro strap, fastening cells' internal skeletons to proteins on their external membranes that connect them with other cells. In species ranging from flies to frogs to mice, it also can transmit early signals that separate an embryo into front and back or top and bottom.

During long-term memory formation, structural changes take place in the synapses the connections between neurons in the brain, says Kerry Ressler, MD, PhD, associate professor of psychiatry and behavioral sciences at Emory University School of Medicine. Ressler is a researcher at Emory University's Yerkes National Primate Research Center, where the research was conducted, and a Howard Hughes Medical Institute investigator.

"We thought beta-catenin could be a hub for the changes that take place in the synapses during memory formation," says Ressler. "But because beta-catenin is so important during development, we couldn't take the standard approach of just knocking it out genetically."

He and graduate student Kimberly Maguschak used a variety of approaches to probe beta-catenin's role in fear memory formation, such as stabilizing the protein with a pulse of the psychiatric drug lithium and injecting a virus that could remove the gene for beta-catenin from brain cells.

If mice are electrically shocked just after they hear a certain tone, they gradually learn to fear that tone, and they show that fear by freezing.

To test beta-catenin's involvement i
'/>"/>

Contact: Kathi Baker
kobaker@emory.edu
404-727-9371
Emory University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Joint NJ/NY Rally for Addiction Recovery to Be Hub of Events Nationwide
2. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
3. Federal Labor Law Violations Provoke Teamster Strike at AmerisourceBergen Northwest Distribution Hub
4. Founding CEOS of SureScripts(R) and RxHub(R) Join Forces to Deliver Clinical Information Technology Services to Physician Practices
5. Epilepsy marked by neural hub network
6. Baker Energy and Huber Receive First-of-its-Kind Award from Wyoming Department of Environmental Quality
7. AVMA Launches Animal Welfare Web Section to Provide Hub for Programs and Information
8. Chubb Expects to Release Earnings on July 24 and Hold Conference Call on the Same Day
9. HUB International New England Reminds Massachusetts Boaters that Safety is Paramount This Summer
10. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
11. Removing Ovaries Before Menopause Leads to Memory, Movement Troubles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... 2014 First Warning Systems, a pioneer ... changes throughout the body, announced the company is changing ... the company’s breadth of upcoming product releases. The initial ... technology. , “Our initial focus will be an ‘Internet ... abnormal circadian cellular changes over time,” said Rob Royea, ...
(Date:10/1/2014)... Join the more than 80 golfers who ... first ever charity golf tournament to benefit Project HEAL, a ... who cannot afford treatment. The tournament will be held Monday, ... , The day-long event starts with 10:30 a.m. check-in ... dinner will begin at 5 p.m. and will include an ...
(Date:10/1/2014)... Innovations announces the upcoming airing of Innovations with ... 20, 2014 at 7:30 a.m. EST/PT via Discovery Channel. ... scenes to learn about Break the Cycle’s comprehensive dating ... help and information Break the Cycle provides to teens ... abuse, how to navigate the legal system, and provides ...
(Date:10/1/2014)... NC (PRWEB) October 01, 2014 Scientists ... of three drugs that target immune system proteins has ... Mesothelioma has just posted details of the new study ... story now. , Researchers in the UWA School ... and anti-CTLA-4 drugs to mice with mesothelioma with promising ...
(Date:10/1/2014)... 01, 2014 October is national Breast ... early detection plans while raising money for breast cancer ... Cancer Awareness Month in the effort to find ... promote the importance of having access to clean, healthy ... be linked to certain forms of cancer. , ...
Breaking Medicine News(10 mins):Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 2Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 3Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 4Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2Health News:New Mesothelioma Study Says Mice Cured by Immuntherapy “Cocktail”, Reports Surviving Mesothelioma 2Health News:Pelican Water Supports Breast Cancer Awareness Month with Order Donations 2
... not exactly help in memory recall. The need of the hour ... 30 seconds. You might look weird doing this in an ... the forgotten facts and figures. ,A study shows that ... eye from one end to the other for 30 seconds every ...
... tenth of Idahos trout population and a loss of ... The outbreak of Ichthyophthirius multifilis has killed around 250,000 trout ... Fish and Game hatchery, in Nampa. This is the second ... probably resulted when stress from overcrowding weakened the fish, making ...
... regard to doctor-patient ratio in various State Government Hospitals ... from case to case depending upon various factors like ... patient-care required i.e. indoor/outdoor. According to the Medical Council ... out to 1:1722. ,The patient nurse ...
... country are 73557. There are 22273 numbers of doctors at ... as on March 2006. As on 1.1.2007, total numbers of ... 340308 beds are available in urban government hospitals including Community ... 92.4% of CHCs are located in government buildings. As on ...
... Lara has thrown a punch at the West Indies Cricket ... named after him. ,He commended the persons and ... Lara Cancer Center for their "teamwork, integrity and use of ... Cricket Board. ,His statement underlines the fact there ...
... quality at western Yamuna canal meets the desired water ... Haridwar, is carrying out water quality monitoring and analysis ... Yamunanagar upstream, Yamunanagar downstream, Panipat downstream and Sonepat upstream ... The monitoring results are being submitted by PCRI to ...
Cached Medicine News:Health News:Eyeing a Good Memory - Not an Exercise in Futility! 2Health News:Disease Outbreak Claims Trout From Idaho Hatchery 2
(Date:10/1/2014)... 2014   Plexus Information Systems, Inc. ... Management Systems (AIMS), announced a partnership with ... owned subsidiary of Quality Systems, Inc. and a ... solutions.  Logo - http://photos.prnewswire.com/prnh/20140930/149406 ... This partnership extends the NextGen Healthcare product ...
(Date:10/1/2014)... Oct. 1, 2014 NeuroCall, Inc., ("NeuroCall") announced ... its Telestroke and Teleneurology services. Dr. Ricardo Garcia-Rivera ... "We are extremely proud that our quality of service ... continue to provide lifesaving support and continuity of care ... throughout the United States ." ...
(Date:10/1/2014)... Oct. 1, 2014 Quantum Materials Corp ... production of photoactive quantum dots for use in ... offering numerous advantages for solar power generation, the ... of quantum dots with which to develop thin ... from commercial utilization and acceptance. The company is ...
Breaking Medicine Technology:Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 2Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 3NeuroCall Awarded Joint Commission Accreditation 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 3
... 16, 2007 - ZIOPHARM Oncology,Inc. (NASDAQ: ZIOP) announced ... active form of ZIO-201 (isophosphoramide mustard,- IPM) at ... in Los Angeles. Data presented demonstrated oral availability,of ... models, including,those with ifosfamide (IFOS) and cyclophosphamide resistant ...
... 2007 - Somanta,Pharmaceuticals (OTCBB:SMPM) today announced that ... later today at the American,Association for Cancer ... poster presentation is entitled "Cytotoxicity of novel,alkylating ... and DNA Mismatch Repair defects," and focuses ...
Cached Medicine Technology:ZIOPHARM Presents Data on Orally Active ZIO-201 at AACR 2ZIOPHARM Presents Data on Orally Active ZIO-201 at AACR 3Somanta Announces the Presentation of Alchemix Data at The American,Association for Cancer Research Annual Meeting 2
Hudson Cranial Drill, complete, consisting of: brace; with extension piece and 4 burs...
23 cm - 9, adult size, for skull thickness up to 12 mm....
Length-9 (229 mm) Tapered retractor blades....
Pattie Tray...
Medicine Products: