Navigation Links
'How well did you sequence that genome?' NIST, consortium partners have answer
Date:2/25/2014

In December 2013, the U.S. Food and Drug Administration approved the first high-throughput DNA sequencer (also known commonly as a "gene sequencer"), an instrument that allows laboratories to quickly and efficiently sequence a person's DNA for genetic testing, medical diagnoses and perhaps one day, customized drug therapies. Helping get the new device approved was another first: the initial use of a reference set of standard genotypes, or "coded blueprints" of a person's genetic traits. The standard genotypes were created by the National Institute of Standards and Technology (NIST) and collaborators within the NIST-hosted Genome in a Bottle consortium.

"Two years ago, NIST hosted Genome in a Bottlea group that includes stakeholders from industry, academia and the federal governmentto develop reference materials that could measure the performance of equipment, reagents and mathematical algorithms used for clinical human genome sequencing," says NIST biomedical engineer Justin Zook. "Our goal is to provide well-characterized, whole genome standards that will tell a laboratory how well its sequencing process is working, sort of a 'meter stick of the genome.'"

Modern DNA sequencers take a genetic sample in the form of long strings of DNA and randomly chop the DNA into small pieces that can be individually analyzed to determine their sequence of letters from the genetic alphabet. Then, bioinformaticians apply complex mathematical algorithms to identify from which part of the genome the pieces originated. These pieces can then be compared to a defined "reference sequence" to identify where mutations have occurred in specific genes.

There are several different DNA sequencing technologies and computer algorithms to do this very complex analysis, and it's known that for any given sample, they will produce similar, but not identical results. Built-in biases as well as what are essentially "blind spots" for certain possible sequences contrib
'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. The Affordable Care Act could have negative consequences for elderly recipients
2. Pacifiers may have emotional consequences for boys
3. Bullying has long-term health consequences
4. The consequences of late preterm birth
5. Mistaking OCD for ADHD has serious consequences
6. USF and VA researchers find long-term consequences for those suffering traumatic brain injury
7. Measuring the consequence of forest fires on public health
8. Long-term consequences of vaginal delivery on the pelvic floor
9. St Jude Retreats Releases New Infographic Which Reports Consequences of Drunk Driving
10. Hello, electronic medical records? Its me, unintended consequences
11. Rutgers-Camden professor examines social capabilities of performing multiple-action sequences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'How well did you sequence that genome?' NIST, consortium partners have answer
(Date:8/30/2014)... As the economy continues to recover ... style bathrooms and in-home fitness centers, the North ... in interest not only in designing and installing saunas ... benefits of sauna. Through working with manufacturers across ... Sauna Society provides a strong knowledge base of Finnish ...
(Date:8/30/2014)... 2014 UWDress.com, a distinguished wedding dress supplier, ... first range of fashionable outfits. Recently, the company has unveiled ... As an autumn special offer, all these brand new products ... , “We are excited to unveil the new and ... high quality products are available at low prices now. The ...
(Date:8/30/2014)... 2014 Recently, Skmen.com, a well-known clothing ... casual dresses . Before the middle of September, all ... discounted price, from 15 to 30 percent off. ... long casual outfits are carefully made and come with ... for the wearers. Skmen.com is popular for its fashionable, ...
(Date:8/30/2014)... Patients suffering from vitiligo can now discover a ... published by Daily Gossip. , Vitiligo is a ... no wonder that numerous sufferers search for an alternative ... one of the most appreciated such methods at the ... the spread of this disorder immediately, while completely curing ...
(Date:8/30/2014)... 30, 2014 The term nutraceuticals ... Pharameuticals. Nutraceuticals is a source of healthy-dietary supplements ... natural food sources. Nutraceutical ingredients have certain curative ... human body. Nutraceutical health products include factors such ... and more. Although nature is the most bountiful ...
Breaking Medicine News(10 mins):Health News:As Interest in Saunas Increases, the North American Sauna Society Increases Outreach to Provide Education on History, Design, and Culture 2Health News:UWDress.com’s Beautiful Collection Of “Flowy Bridesmaid Dresses” Released 2Health News:Huge Deals On 2014 Long Casual Dresses Unveiled By Skmen.com 2Health News:Natural Vitiligo Treatment Review Exposes Fast Method for Skin Repigmentation 2Health News:A Granular Analysis of the Nutraceutical Ingredients Market by Transparency Market Research 2Health News:A Granular Analysis of the Nutraceutical Ingredients Market by Transparency Market Research 3Health News:A Granular Analysis of the Nutraceutical Ingredients Market by Transparency Market Research 4
... SHENZHEN, China, Feb. 13 /PRNewswire-Asia/ -- Winner Medical Group Inc.,(OTC ... financial results for the first quarter ended December 31,2008. The ... with,the United States Securities and Exchange Commission. , , ... Total net sales revenue increased by 33.14% over the first ...
... the University of Brighton Medical School has chosen a Mecmesin MultiTest ... orthopaedic prosthesis for shoulder reconstruction. , ... Slinfold, West ... orthopaedic surgeon at the University of Brighton Medical School has chosen ...
... share most of their genes, including 70 percent of ... remarkable evolutionary conservation, researchers at the Salk Institute for ... model for an innovative study of gliomas, the most ... disease but we still know very little about the ...
... 44%, researchers say , , THURSDAY, Feb. 12 (HealthDay News) ... much as a 44 percent increased risk of developing ... has established a connection between smoking and increased risk ... the largest review to date showing a link between ...
... Feb. 12 Biotel Inc.,(OTC Bulletin Board: BTEL) announced ... net earnings of $289,000, or $0.10 per diluted share,on ... $206,000, or $0.07,per diluted share, on revenues of $2,859,000 ... months ended December 31, 2008, Biotel had net earnings ...
... The Pennsylvania Department of Health has reviewed and ... Hospital in Brownsville, Fayette County, which ceased operations ... have been relocated to other facilities. All hospital ... work, assisted with the patient transfer.Local ambulances and ...
Cached Medicine News:Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 2Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 3Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 4Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 5Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 6Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 7Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 8Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 9Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 10Health News:Force Tester Shoulders The Burden 2Health News:Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers 2Health News:Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers 3Health News:Secondhand Smoke Linked to Dementia 2Health News:Biotel Announces Profitable Second Quarter Ended December 31, 2008 2
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "Global Multiple Sclerosis Drugs Market 2014-2018" report ... a chronic, inflammatory medical condition that results in demyelination, ... because of an abnormal response by the immune system, ... It is a potentially debilitating disease in which the ...
(Date:8/29/2014)... -- Pixcelldata, the innovative Irish developer of ... major new deal with Dutch based eX-Path, global providers ... Marius Nap . The announcement was ... Pathology which is taking placing between August 30th and ... where Pixcelldata will demonstrate its innovative solution. ...
(Date:8/28/2014)...  Rigrodsky & Long, P.A.: , Do you, ... LCI )? , Did you purchase your shares before ... 2014, inclusive? , Did you lose money in your ... to discuss your rights? Rigrodsky & ... Timothy J. MacFall , announces that a complaint has been filed ...
Breaking Medicine Technology:Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3
... test kit is an enzyme immunometric ... with a liquid phase,incubation, designed for ... serum. The microplate is coated,with anti-rabbit ... to anti-rabbit antibody-coated wells, along with ...
Vitamin B6 Jumbo REA Vitamin Assays, Cardiovascular 001-RK-VB6N...
Myoglobin EIA Lipid / Protein Quantification, Cardiovascular 024-IDC-13 Muscle Disease...
IGF-BP3 EIA Endocrine Function 022-IGF-E03 Insulin Growth Factor binding protein...
Medicine Products: