Navigation Links
How tumor cells create their own pathways
Date:7/10/2012

How does a tumor cell set up a signaling pathway in order to metastasize? Scientists at Technische Universitt Mnchen's (TUM) Klinikum rechts der Isar and Helmholtz Zentrum Mnchen have made a significant discovery in this area by studying colon cancer. They have learned that the tumor cells release certain proteins known as chemokines. In the case of metastatic colon cancer cells, the chemokine concerned is CCL2. The CCL2 chemokine docks on to the cells of the inner blood vessel walls (endothelial cells) and activates the corresponding receptor (CCR2 receptor). This connection makes the endothelial cells permeable creating a clear path for the tumor cells.

Professor Mathias Heikenwlder of TUM's Institute of Virology explains that the tumor cells use a clever trick to migrate: "The tumor cells outwit the endothelial cells by emitting a signal used by healthy cells." To date, research has mainly focused on macrophage cells attracted by the chemokines of the tumors. "By understanding the role of chemokine receptors in relation to endothelial cells we have potentially uncovered a brand new approach to cancer treatment," says Heikenwlder.

"Measuring the number of chemokines could allow us to draw clear conclusions on the likely spread of a primary tumor to other organs and predict the risk of metastasis in patients," continues Heikenwlder. "Furthermore, the option of blocking the chemokine receptor CCR2 at the endothelial cells gives healthcare professionals a new way of preventing metastases both before and following an operation."

For their research, the scientists used colon cancer tissue and colon cancer cell lines from mice and humans. The next steps will involve studying the findings in greater detail and examining how the new concept can be transferred to other types of cancer.


'/>"/>
Contact: Barbara Wankerl
wankerl@zv.tum.de
49-892-892-2562
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1

Related medicine news :

1. Drug from Mediterranean weed kills tumor cells in mice
2. Pediatric tumors traced to stem cells in developing brain​​
3. Skin contact breast tumor detection
4. Specialized MRI scans assess value of anti-cancer chemotherapy long before tumors shown to shrink
5. Celebrex-derived drug targets common childhood bone tumor
6. Notre Dame researchers paper examines the biology of tumor-derived microvesicles
7. Gene sequencing project identifies potential drug targets in common childhood brain tumor
8. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
9. Researchers determine pathway for origin of most common form of brain and spinal cord tumor
10. Mount Sinai researchers develop a multi-target approach to treating tumors
11. Modeling the demise of migrating brain tumor cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How tumor cells create their own pathways
(Date:8/16/2017)... ... August 16, 2017 , ... Modern Consulting Insurance & ... program. Partnering once again with Boys & Girls Clubs of Greater Kansas City, ... area’s very own American Idol. With all proceeds benefitting local worthy causes, donations ...
(Date:8/16/2017)... GA (PRWEB) , ... August 16, 2017 , ... ... for Telehealth, Inc. has received a three-year grant totaling $975,000, renewing its funding ... of Health and Human Services. , This funding marks, the fourth time the ...
(Date:8/16/2017)... ... August 16, 2017 , ... LabRoots , the leading provider of ... world, is excited to announce Andrew Ly as the winner of the LabRoots Summer ... costs. , Ly, who is in his third year at the University of ...
(Date:8/16/2017)... ... , ... With a new PD diagnosis every nine minutes, research is critical ... are awarded through a competitive application process and reviewed by APDA’s Scientific Advisory Board ... in all areas relevant to PD research. The SAB meets annually to review ...
(Date:8/16/2017)... ... August 16, 2017 , ... Melbourne’s reign as the world’s most liveable city ... (EIU) annual Liveability Index. , The Index surveys 140 of the world’s cities and ... Melbourne has consistently come in the top three of the index. So what is ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... , Aug. 7, 2017 Diplomat Pharmacy, Inc. ... Joel Saban as president, effective Aug. 7, 2017. ... has decided to pursue other interests and will serve ... his tenure, Paul has served us in multiple leadership roles ... Pharmacy in Jun. 2015 and has provided decisive, strategic leadership ...
(Date:8/7/2017)... -- Endo International plc (NASDAQ: ENDP ) today ... known U.S. mesh product liability claims and that it ... U.S. claims at reasonable values. Under the agreements, Endo ... of 2017 and continuing through the fourth quarter of ... the Company intends to increase its mesh product liability ...
(Date:8/4/2017)... 2017  Agragen, LLC, a Cincinnati ... biopharmaceutical, nutraceutical, and aquacultural feed sectors, announces a ... drug candidates, AGR131.  This drug is designed to ... blood of patients suffering from inflammatory conditions such ... Biological pharmaceuticals ...
Breaking Medicine Technology: