Navigation Links
How tumor cells create their own pathways
Date:7/10/2012

How does a tumor cell set up a signaling pathway in order to metastasize? Scientists at Technische Universitt Mnchen's (TUM) Klinikum rechts der Isar and Helmholtz Zentrum Mnchen have made a significant discovery in this area by studying colon cancer. They have learned that the tumor cells release certain proteins known as chemokines. In the case of metastatic colon cancer cells, the chemokine concerned is CCL2. The CCL2 chemokine docks on to the cells of the inner blood vessel walls (endothelial cells) and activates the corresponding receptor (CCR2 receptor). This connection makes the endothelial cells permeable creating a clear path for the tumor cells.

Professor Mathias Heikenwlder of TUM's Institute of Virology explains that the tumor cells use a clever trick to migrate: "The tumor cells outwit the endothelial cells by emitting a signal used by healthy cells." To date, research has mainly focused on macrophage cells attracted by the chemokines of the tumors. "By understanding the role of chemokine receptors in relation to endothelial cells we have potentially uncovered a brand new approach to cancer treatment," says Heikenwlder.

"Measuring the number of chemokines could allow us to draw clear conclusions on the likely spread of a primary tumor to other organs and predict the risk of metastasis in patients," continues Heikenwlder. "Furthermore, the option of blocking the chemokine receptor CCR2 at the endothelial cells gives healthcare professionals a new way of preventing metastases both before and following an operation."

For their research, the scientists used colon cancer tissue and colon cancer cell lines from mice and humans. The next steps will involve studying the findings in greater detail and examining how the new concept can be transferred to other types of cancer.


'/>"/>
Contact: Barbara Wankerl
wankerl@zv.tum.de
49-892-892-2562
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1

Related medicine news :

1. Drug from Mediterranean weed kills tumor cells in mice
2. Pediatric tumors traced to stem cells in developing brain​​
3. Skin contact breast tumor detection
4. Specialized MRI scans assess value of anti-cancer chemotherapy long before tumors shown to shrink
5. Celebrex-derived drug targets common childhood bone tumor
6. Notre Dame researchers paper examines the biology of tumor-derived microvesicles
7. Gene sequencing project identifies potential drug targets in common childhood brain tumor
8. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
9. Researchers determine pathway for origin of most common form of brain and spinal cord tumor
10. Mount Sinai researchers develop a multi-target approach to treating tumors
11. Modeling the demise of migrating brain tumor cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How tumor cells create their own pathways
(Date:2/22/2017)... ... February 22, 2017 , ... Becker’s Spine Review, the leading ... Michigan neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon to Know.” http://www.beckersspine.com/spine-leaders/item/35348- ... in Michigan performing minimally invasive back surgery that often results in less post-operative ...
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five percent of ... report that family members or friends have also commented about their poor hearing. ... wear hearing aids. One reason, suggested by 89 percent of American respondents, is ...
(Date:2/22/2017)... ... ... Social media marketing is transitioning from a singular person activity to a collaborative ... this insight and more in its latest episode of its Brains Over Brawn podcast. ... social media strategist and partner of the digital firm Med|Ed Digital Jessica Columbo. Jessica ...
(Date:2/22/2017)... ... February 22, 2017 , ... In ... advocates stress that the patient context (age, illness and life choices) should be ... mitigate their occurrence. In addition, all too often, studies regarding health ...
(Date:2/21/2017)... Australia (PRWEB) , ... February 22, 2017 , ... Author ... it is valuable for every household and family to know all about it for ... publishing world with the release of “ Detox, Digestive and Wellness Solutions ” (published ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... and HAMBURG, Germany , February 22, 2017 ... precision oncology headquartered in Hamburg, Germany and ... research institution, announced today a collaboration to support the first Indian ... research. ... Indivumed signed an agreement with an initial three-year term. The collaboration ...
(Date:2/22/2017)... , Feb. 22, 2017  Soligenix, Inc. (Nasdaq: ... a late-stage biopharmaceutical company focused on developing and ... is an unmet medical need, announced today that ... granted a European patent for the treatment of ... methods of treatment of skin conditions, complements the ...
(Date:2/21/2017)... Feb. 21, 2017 Mass Spectrometer Market: ... http://www.reportlinker.com/p04711309-summary/view-report.html This report on mass ... future prospects of the market globally. The stakeholders ... in the manufacture and commercialization of various mass ... entrants planning to enter this market. This report ...
Breaking Medicine Technology: