Navigation Links
How to shoot the messenger
Date:1/26/2010

Hamburg, 26 January 2010 Cells rely on a range of signaling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of developing new drugs to tackle disorders like neurodegeneration, cancer and cardiovascular disease. In a study published today in Science Signaling, they have pieced together the first snapshot of what two of the system's components look like while interacting.

One way these signalling systems work is by triggering a flood of calcium ions inside the cell. These get picked up by a receiver, a protein called calmodulin which turns this calcium signal into action by switching various parts of the cell's machinery on or off. Calmodulin regulates a set of proteins called kinases, each of which controls the activity of specific parts of the cell, thus altering the cell's behaviour.

Using high-energy X-rays produced by the European Synchrotron Radiation Facility (ESRF) in Grenoble, France, and by the German Synchrotron Radiation Centre (DESY), in Hamburg, Germany, Matthias Wilmanns' team at EMBL revealed the molecular structure of one of these kinases, a protein called Death-Associated Protein Kinase DAPK, when bound to calmodulin. The structure showed how calmodulin binds to a particular section of DAPK, switching the kinase on so that it can go and change the function of its targets. The team then worked out which of DAPK's building blocks, or amino acids, were crucial for calmodulin to bind.

"Faulty versions of DAPK are involved in the development of some cancers," says Wilmanns, "so we want to know more about how this protein functions to allow its better exploitation as an anti-cancer target."

What's more, DAPK has physical similarities to many of the other kinases controlled by calmodulin, meaning many of them are l
'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Does Pathological Shyness Make for School Shooters?
2. New Jersey Nets Shoot Down Staph with High-Tech Defense
3. The SCOOTER Store Donates Power Wheelchair to Paraplegic, a Victim of Accidental Shooting
4. 15th Anniversary Celebration Shoot For a Cure Event Slated for Nov. 8
5. In Wake of Omaha Shooting, Mental Health America Provides Tips to Holiday Shoppers to Ease Anxieties
6. For Virginia Tech Community, Anxiety and Sadness May Increase on Anniversary of School Shootings
7. ATF Offers $10,000 Reward for Information to Solve Shooting and Theft of Guns Case
8. The Sudden Cardiac Arrest Association Shoots Straight for the Heart
9. Mexico Presents Flawed Theory in Shooting Death of American Journalist
10. Suicide by cop phenomenon occurring in over a third of North American shootings involving police
11. Shootings Linked to Alcohol-to-Go Outlets, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How to shoot the messenger
(Date:10/20/2014)... 2014 Women’s health specialist, Dr. Amber ... Gynecology of Columbus, Inc., A Division of MaternOhio Clinical ... more than 100,000 patients annually. Dr. Murphy will provide ... stages of a women’s life. She is accepting new ... Westerville and Dublin. , Dr. Murphy offers a wide ...
(Date:10/20/2014)... Zereana Jess-Huff, a 34-year-old mother, corporate executive and ovarian cancer ... think outside the bra. She doesn’t try to hide her ... about women’s other lady parts. , "We have won the ... pink and everybody knows what you’re talking about,” Jess-Huff points ... not been won when it comes to gynecologic cancers. It ...
(Date:10/20/2014)... Principle Business Enterprises, a family owned ... top-of-the-line absorbent products. The company has recently made ... brand, Tranquility® Premium Protection absorbent products. The company ... its packaging a new look, and is currently working ... the public. , The new website, developed with Thread ...
(Date:10/20/2014)... October 20, 2014 Rockynol Retirement ... Center on Oct. 14. The $11 million project will ... and a cooked-to-order kitchen with full-service restaurant style dining. ... choice for first class Assisted Living apartments,” said Kara ... deserve the highest quality of care and this investment ...
(Date:10/20/2014)... National Teen Driver Safety Week is October 19-25, 2014 ... (Ohio AAP, http://www.ohioaap.org ) is joining the National Highway ... to talk to their teens and always set the rules ... the leading cause of death for U.S. teens. In 2012, ... 859 (42%) of those teen drivers were killed in crashes. ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2
... Brands Donate $500,000 To Help Americans Live Heart-Healthy, ... North America Inc. today announced that it is ... heart health and encouraging healthy habits among Americans. ... the American Heart Association to address the dangers ...
... Office Expands with Appointment of New Strategic Talent -WEST ... strategic interactive marketing agency serving the healthcare industry, today ... the addition of four key new hires. Three of ... Group,s Manhattan offices which were established in 2007."We,re excited ...
... Practicing Clinicians Exchange (PCE) has formed a partnership ... to provide immunization continuing education programs to nurse practitioners ... In recognition of these vital healthcare providers, expanding role ... Updates throughout the year as part of the PCE ...
... generously during 2008 holiday shopping seasonFORT WORTH, Texas, Feb. ... its customers, raised nearly $1.5 million for the fifth-annual ... and fundraising initiative for St. Jude Children,s Research Hospital ... , Customers who shopped at RadioShack stores had ...
... Hospice By The Bay,s eight-week group provides teens, ages 13-17, who are ... to be with other young people who are grieving. , ... Larkspur, ... adults. Hospice By The Bay ,s eight-week group provides teens, ages ...
... Direct, Inc., a leading online retailer of contact lenses in the United ... from dry winter eyes can be easily prevented. , ... Bellevue, WA ... online retailer of contact lenses in the United States wants ...
Cached Medicine News:Health News:Leading Spring Water Brands From Nestle Waters Team Up With the American Heart Association START! Initiative 2Health News:Leading Spring Water Brands From Nestle Waters Team Up With the American Heart Association START! Initiative 3Health News:Cadient Group Continues Growth Trend with Key New Hires 2Health News:Practicing Clinicians Exchange Forms Partnership with CDC 2Health News:RadioShack Helps Raise $1.5 Million for St. Jude Children's Research Hospital(R) Fifth-Annual Thanks and Giving(R) Campaign 2Health News:RadioShack Helps Raise $1.5 Million for St. Jude Children's Research Hospital(R) Fifth-Annual Thanks and Giving(R) Campaign 3Health News:Hospice By The Bay Teen Grief Group Offers Support for Ages 13-17 2Health News:Contact Lens Wearers Should Blink More Often During Winter - Tips from VisionDirect.com to Keep Eyes Moist During Dry Winter Months 2Health News:Contact Lens Wearers Should Blink More Often During Winter - Tips from VisionDirect.com to Keep Eyes Moist During Dry Winter Months 3
(Date:10/20/2014)... VIEW, California , 20 de octubre de ... líder en el campo de la pulmonología intervencional, ... su Estudio RENEW, casi 3 meses antes de ... fundamental de exención de dispositivo de investigación (IDE) ... Medicamentos) para el sistema de espiral de reducción ...
(Date:10/20/2014)... 20, 2014  ResMed (NYSE: RMD ... Data Exchange program, a comprehensive suite of software ... and other health care providers. ... critical patient information. It integrates valuable sleep and ... patient management platforms with customers, in-house or third-party ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., ... therapeutic antibodies, today announced the appointment of ... Dr. Londei will lead the preclinical and clinical ... "We are pleased to welcome Dr. Londei ... Suria , President and Chief Executive Officer of ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3ResMed Launches ResMed Data Exchange 2AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... Top 10 Medical Innovations for 2010 list features a wide ... to treat everything from deafness and Parkinson,s disease to pneumonia ... and therapies was selected by a panel of Cleveland Clinic ... Cleveland Clinic,s 2009 Medical Innovation Summit , which is ...
... Inc., a manufacturer of medical devices, today announced that ... of the single-patient use Manual Pulmonary Resuscitator (MPR). The ... March 2008 and matching the lot numbers listed on ... . This recall is being conducted because of ...
Cached Medicine Technology:Cleveland Clinic Unveils 'Top 10' Medical Innovations for 2010 2Cleveland Clinic Unveils 'Top 10' Medical Innovations for 2010 3Cleveland Clinic Unveils 'Top 10' Medical Innovations for 2010 4Unomedical Issues Worldwide Recall of Certain Manual Pulmonary Resuscitators 2
... system has been designed to ... The maneuverability of this system ... fatigue-free viewing even at the ... in posterior fossa, cerebral tumor, ...
Wide Field Surgical Prism Loupes...
... 40 cm field-of-view enables high-quality full-coverage body ... scalable 32-channel architecture. New powerful Quasar Dual ... up to 80 mT/m SR ... to fully exploit the power of 3.0T ...
... Allegra is the ultimate brain machine. ... optimized for best image quality and ... in a highly compact design. ,These ... stroke, epilepsy, tumor and multiple sclerosis. ...
Medicine Products: