Navigation Links
How to shoot the messenger
Date:1/26/2010

Hamburg, 26 January 2010 Cells rely on a range of signaling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of developing new drugs to tackle disorders like neurodegeneration, cancer and cardiovascular disease. In a study published today in Science Signaling, they have pieced together the first snapshot of what two of the system's components look like while interacting.

One way these signalling systems work is by triggering a flood of calcium ions inside the cell. These get picked up by a receiver, a protein called calmodulin which turns this calcium signal into action by switching various parts of the cell's machinery on or off. Calmodulin regulates a set of proteins called kinases, each of which controls the activity of specific parts of the cell, thus altering the cell's behaviour.

Using high-energy X-rays produced by the European Synchrotron Radiation Facility (ESRF) in Grenoble, France, and by the German Synchrotron Radiation Centre (DESY), in Hamburg, Germany, Matthias Wilmanns' team at EMBL revealed the molecular structure of one of these kinases, a protein called Death-Associated Protein Kinase DAPK, when bound to calmodulin. The structure showed how calmodulin binds to a particular section of DAPK, switching the kinase on so that it can go and change the function of its targets. The team then worked out which of DAPK's building blocks, or amino acids, were crucial for calmodulin to bind.

"Faulty versions of DAPK are involved in the development of some cancers," says Wilmanns, "so we want to know more about how this protein functions to allow its better exploitation as an anti-cancer target."

What's more, DAPK has physical similarities to many of the other kinases controlled by calmodulin, meaning many of them are likely to interact with calmodulin in the same, or similar ways. Being able to see the three-dimensional structures of these proteins, how they clip together and alter each other's behaviour means researchers can devise ways to manipulate this interaction with drugs.

"That will provide a platform to get into drug discovery," says Wilmanns, adding, "obviously, this is the beginning of the story." He is planning to do so in an ongoing collaboration with Adi Kimchi's team at the Weizmann Institute in Israel and other groups from EMBL.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Related medicine news :

1. Does Pathological Shyness Make for School Shooters?
2. New Jersey Nets Shoot Down Staph with High-Tech Defense
3. The SCOOTER Store Donates Power Wheelchair to Paraplegic, a Victim of Accidental Shooting
4. 15th Anniversary Celebration Shoot For a Cure Event Slated for Nov. 8
5. In Wake of Omaha Shooting, Mental Health America Provides Tips to Holiday Shoppers to Ease Anxieties
6. For Virginia Tech Community, Anxiety and Sadness May Increase on Anniversary of School Shootings
7. ATF Offers $10,000 Reward for Information to Solve Shooting and Theft of Guns Case
8. The Sudden Cardiac Arrest Association Shoots Straight for the Heart
9. Mexico Presents Flawed Theory in Shooting Death of American Journalist
10. Suicide by cop phenomenon occurring in over a third of North American shootings involving police
11. Shootings Linked to Alcohol-to-Go Outlets, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How to shoot the messenger
(Date:9/23/2017)... ... ... “You Can't Win Them All”: the story of an entrepreneur and a family man ... the lives of young athletes. “You Can't Win Them All” is the creation ... a small town in Northern Ontario, Canada. He is an entrepreneur who manages ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... and Richard Pedranti Architect (RPA), a full-service architecture firm focusing on ... Solsken Line of Model Homes . Independently, Ecocor and RPA have extensive ...
(Date:9/22/2017)... ... September 22, 2017 , ... Pullano Law Offices, a Chicago personal ... has been selected to serve as President of the North Suburban Bar Association ... and Award Dinner hosted by the NSBA at the North Shore Country Club in ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... you brush more effectively even on the go. Their electric toothbrushes aggressively attack ... gum inflammation, with UV sanitizing technology. Combining leading edge Enke technology with a ...
(Date:9/22/2017)... Greenwich, Connecticut (PRWEB) , ... September 22, 2017 ... ... to conquering Lyme and other tick-borne diseases through research, education and awareness, today ... , A noted immunologist and microbiologist, Dr. Sellati has more than 20 ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... Pa. and KALAMAZOO, Mich. , Sept. 18, ... , and OptiMed Specialty Pharmacy of ... to offer a strategic hub service that expedites and ... sought-after personal spirometer, Spiro PD 2.0, and wellness management ... spirometer is a medical device used to measure lung ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform ... published the first annual edition of its Global CSR Risk and Performance ... evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data ... ... ...
(Date:9/9/2017)... ... ... – Monday, September 18 th .The Brain Tumor Foundation (BTF) begins ... the public.Where:  BTF,s Mobile MRI Unit – a ... Washington, D.C.What:BTF brings its nationwide initiative, the Road to Early Detection Sponsor-A-City ...
Breaking Medicine Technology: