Navigation Links
How to design a cancer-killing virus
Date:10/25/2007

One new way to treat individuals with cancer that is being developed is the use of viruses that infect and kill cancer cells while leaving normal cells unharmed. These viruses are known as virotherapeutics. In a new study, David Kirn and colleagues at Jennerex Biotherapeutics, San Francisco, have described the development of a new virotherapuetic with antitumor effects in both mice and rabbits.

After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific cancer cells those with increased expression of a protein known as E2F and/or activation of signaling downstream of a protein known as EGFR. Further engineering to enable the virus to produce the soluble factor GM-CSF was designed to enhance the induction of anti-tumor immune responses. In addition to its antitumor effects in mice and rabbits, the virotherapeutic showed high selectivity for cancer cells in tumor-bearing rabbits and in human tissue samples, leading the authors to suggest that this virotherapeutic should be tested in clinical trials for the treatment of cancer.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. First Vaccine Designed for Africa Cleared for Testing in Humans
2. Designer baby for British couple
3. New !! “Designer” Gene Theray
4. Couples in Britain can have “designer” babis
5. Nanocubes Designed For Delivering Cells
6. Designer Rats Reveal Possible Heart Disease Genes
7. Designer Babies- To Create Or Not To Create!
8. Zactima Receives Fast Track Designation By The FDA
9. Dr.Tadataka Yamada Designated to open Gates for Global Health Program
10. New Test Offers Hope in Effective Hearing Aid Design for Babies
11. A Couple To Create A Designer Baby As A “Saviour Sibling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... Tampa, FL (PRWEB) , ... December 08, 2016 ... ... been awarded accreditation with distinction by the Undersea and Hyperbaric Medical Society (UHMS), ... patients with advanced care and patient safety. Only a few hospitals and facilities ...
(Date:12/8/2016)... ... December 08, 2016 , ... ZyDoc ... Language Processing–Enabled and Conventional Data Capture Methods for Input to Electronic Health Records: ... , Results of the comparative usability study demonstrate that a dictation-based method (“NLP ...
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the nation’s leading ... has aligned with Upstage Lung Cancer in efforts to combat lung cancer, announced CURE ... Hennessy, Jr said, “CURE Media Group is honored to team up with Upstage Lung ...
(Date:12/8/2016)... ... December 08, 2016 , ... Premier Fitness Camp (PFC) and The Chopra ... weight loss and wellness program, at their world headquarters of Omni La Costa Resort ... long-term results to anyone seeking weight loss, personal development, a healthy lifestyle, or mental ...
(Date:12/8/2016)... ... December 08, 2016 , ... Catalent Pharma Solutions, the leading ... consumer health products, today announced that it had joined the Pharmaceutical Supply Chain ... organization to unite pharmaceutical and healthcare companies that share a vision of better, ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... LONDON , December 9, 2016 ... ICD, Subcutaneous ICD, Single-Chamber ICD, Dual-Chamber ICD, Cardiac ... External Defibrillators, Wearable Cardioverter Defibrillators The ... grow at a CAGR of 5.3% from 2016-2020 ... is expected to grow at a CAGR of ...
(Date:12/9/2016)... Research and Markets has announced the addition of the "High ... offering. ... analyses the market by the following Technology Types: Label-Free Technology, Cell-Based Assay, ... Canada , Japan , Europe ... , and Rest of World. Annual estimates and forecasts ...
(Date:12/9/2016)... Research and Markets has announced the ... 2021" report to their offering. ... Market growth can be ... the pharmaceutical and biotechnology industry and technological advancements like automation ... markets and growing research activities in toxicology and stem cells ...
Breaking Medicine Technology: