Navigation Links
How to design a cancer-killing virus
Date:10/25/2007

One new way to treat individuals with cancer that is being developed is the use of viruses that infect and kill cancer cells while leaving normal cells unharmed. These viruses are known as virotherapeutics. In a new study, David Kirn and colleagues at Jennerex Biotherapeutics, San Francisco, have described the development of a new virotherapuetic with antitumor effects in both mice and rabbits.

After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific cancer cells those with increased expression of a protein known as E2F and/or activation of signaling downstream of a protein known as EGFR. Further engineering to enable the virus to produce the soluble factor GM-CSF was designed to enhance the induction of anti-tumor immune responses. In addition to its antitumor effects in mice and rabbits, the virotherapeutic showed high selectivity for cancer cells in tumor-bearing rabbits and in human tissue samples, leading the authors to suggest that this virotherapeutic should be tested in clinical trials for the treatment of cancer.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. First Vaccine Designed for Africa Cleared for Testing in Humans
2. Designer baby for British couple
3. New !! “Designer” Gene Theray
4. Couples in Britain can have “designer” babis
5. Nanocubes Designed For Delivering Cells
6. Designer Rats Reveal Possible Heart Disease Genes
7. Designer Babies- To Create Or Not To Create!
8. Zactima Receives Fast Track Designation By The FDA
9. Dr.Tadataka Yamada Designated to open Gates for Global Health Program
10. New Test Offers Hope in Effective Hearing Aid Design for Babies
11. A Couple To Create A Designer Baby As A “Saviour Sibling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that ... the risk of visual loss in these patients. , But how often do ophthalmologists ... smoking cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... ... , ... Military Connection friend and veteran advocate Micaela Bensko and ... lounge. , Bensko is no stranger to the plight of the disabled. Before ... to supporting our wounded veterans. A world-class photographer, her riveting photos “The Wounds of ...
(Date:6/23/2017)... , ... June 23, 2017 , ... The Aesthetic Channel ... . Dr. Talei has come up with a proprietary technique that he calls the ... tissues that have dropped. For all ages, patients can expect to look refreshed, rejuvenated, ...
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and South ... selected 21 leaders from government, business and civil society in 11 countries across the ... this fall, engaging in a transformative exchange of knowledge and ideas with the leading ...
(Date:6/23/2017)... ... 2017 , ... Ross Insurance Agency ( http://www.rossinsuranceagency.com ) saves ... Agency’s (FEMA) recent update of flood zones, more people than ever are in ... enacted to reflect the actual risk in flood zone areas during a time ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... HAMPTON, Va. , June 14, 2017  ivWatch ... safety and effectiveness of intravenous (IV) therapy, is pleased ... in the category of Nonsurgical Hospital Supplies and Equipment ... premier awards program for the medtech industry. The award ... at the Jacob K. Javits Center in ...
(Date:6/13/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a ... Food and Drug Administration (FDA) has notified the Company that ... Zhejiang, China manufacturing facility has been ... clearance of the Warning Letter related to our ... of the progress we have made in our ongoing quality ...
(Date:6/10/2017)... 9, 2017  Shane K. Burchfield, DPM, is recognized by Continental ... a Podiatrist in Alabama . ... Foot Care. He brings over 20 years of experience, as well ... healthcare, to his role. ... is pleased to welcome you to his practice," the ...
Breaking Medicine Technology: