Navigation Links
How to confirm the causes of iron deficiency anemia in young women
Date:6/23/2009

Iron-deficiency anaemia (IDA) is commonly seen in women aged <50 years. The diagnostic workflow in young women affected by IDA is not clearly established. The British Society of Gastroenterology recommends gastroscopy only in IDA women younger than 45 years presenting with gastrointestinal (GI) symptoms. However, symptoms are often mild and aspecific in IDA women and the gastroscopy is an invasive procedure associated with a high number of refusals. In a previous work on IDA premenopausal women, gastroscopy was performed in all patients, later deemed unnecessary in almost 30% of the studied women because these were affected only by menorrhagia.

A research team led by Bruno Annibale from Italy prospectively evaluate the usefulness of a pre-endoscopic serological screening for H. pylori infection and celiac disease with the use of two tests (human recombinant tissue transglutaminase IgA antibodies and anti-H. pylori IgG antibodies) in women aged < 50 affected by IDA in order to increase the compliance for gastroscopy. Their study will be published on June 14, 2009 in the World Journal of Gastroenterology

In this study, 115 women aged < 50 years with IDA were tested by human recombinant tissue transglutaminase IgA antibodies (tTG) and anti-H. pylori IgG antibodies. All cases underwent gastroscopy with biopsies of stomach and duodenum, irrespective of tests results. Of the 115 patients, 45.2% of women were test-positive. The serological results were confirmed by gastroscopy in 100% of those with positive H. pylori antibodies, in 50% of those with positive tTG and in 81.5% of test-negative patients. Sensitivity and specificity were 84.8% and 100% for H. pylori infection, and 80% and 92.8% for tTG, respectively. The gastroscopy compliance rate of test-positive women was significantly increased in comparison with those test-negative (65.4% vs 42.8%; Fisher test P = 0.0239).

This study showed that two simples and widely available tests, such as those for tissue transglutaminase IgA antibodies and anti-H. pylori IgG antibodies, were able to select women with IDA to submit for gastroscopy to identify IDA-related GI causes and to increase the compliance for the invasive procedure. Gastroscopy with biopsies confirmed in the vast majority of IDA women the presence of active H. pylori pangastritis, atrophic gastric body, or celiac disease as possible causes of IDA.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. GAO Report Confirms: Medicare Underpays for Anesthesia Services; Nurse Anesthetists Assure Seniors Access to Safe Anesthesia Care
2. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
3. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
4. PA Game Commission: EHD Outbreak Update: Test Results Confirm EHD In Beaver County
5. Actavis Confirms its Patent Challenge of Kings Avinza(R)
6. Barr Confirms Patent Challenge of UROXATRAL(R)
7. Pennsylvania Game Commission Announces EHD Confirmed in Allegheny and Westmoreland Counties
8. Perrigo Confirms Filing for Generic Version of Mucinex(R) and Announcement of Lawsuit by Adams Respiratory
9. Use of Technology to Document Comorbid Conditions May Improve Reimbursement, Increase Documentation Accuracy Study Confirms
10. Newly Published Study in Leading Medical Journal Further Confirms the Brava Systems Non-Surgical Breast Enhancement Effectiveness
11. LUNA Pure Prevention Survey Confirms Breast Cancer Misconceptions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... Maryland (PRWEB) , ... March 24, 2017 , ... ... is the first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I ... their caregivers during what is often a very difficult and challenging time.” , ...
(Date:3/24/2017)... ... ... “End Time GPS”: a dauntless and enlightened study of the second-coming of Christ, ... of published author, Wesley Gerboth, a World War II veteran, with a highly-regarded reputation ... age ninety-one, he shares the Wisdom God bestowed upon him in this publication. ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The ... about real people of God in congregations across the United States. “The ... minister ordained in 1964 who has served congregations in seven states throughout his ...
(Date:3/23/2017)... ... March 23, 2017 , ... In 2016 the World Health ... there could be four million Zika-related cases in the Americas within the next year. ... US cases reported per year skyrocketing to an estimated 329,000. Yet, Zika, Lyme and ...
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the opening ... at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the new ... in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an even ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- GenomeDx Biosciences today announced that six abstracts featuring Decipher ... Classifier tests will be presented at the 32 nd ... March 24 to 28, 2017 in London, ... Europe,s largest urological event showcasing the ... The abstract titled "Muscle invasive bladder cancer: ...
(Date:3/24/2017)... GENEVA , March 24, 2017 ... efforts to develop sutezolid as effective response to infectious ... TB Alliance and the Medicines Patent Pool (MPP) announced ... an antibiotic drug candidate which demonstrated encouraging results in ... sutezolid in combination with other TB drugs and follows ...
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Procedure By Technique, Repair Procedure By Technique, By Region, By Country ... ... to grow at a CAGR of 13.35% during 2016-2021 ... aging population, growth in population with heart disease and rising advances ...
Breaking Medicine Technology: