Navigation Links
How the fluid between cells affects tumors
Date:7/25/2012

July 25, 2012

There are many factors that affect tumor invasion, the process where a tumor grows beyond the tissue where it first developed. While factors like genetics, tissue type and environmental exposure affect tumor metastasis and invasion, physical forces like fluid flow remain a poorly understood component of tumor invasion. A new video article in JoVE, the Journal of Visualized Experiments, describes a novel procedure that allows researchers to study and test the microenvironment of a growing tumor. The technique is valuable because it allows scientists to assay tumor invasion attributable to extracellular fluid flow in vitro and better understand the effects of such physical changes on a tumor. The study focuses specifically on a type of extracellular fluid called interstitial fluid, which flows between cells in a tissue. This procedure is a significant first step to develop an in vitro system that better mimics what happens within a growing tumor in the patient.

"Our goal is to understand how physical forces affect how tumor cells behave. By understanding factors influencing why a tumor does or does not spread, we will have a much better understanding of which therapies will affect the tumor," said the article's author Dr. Adrian Shieh of Drexel University.

As tumors grow, they promote angiogenesis, or growth of new blood vessels, within the tumor itself and the surrounding tissue. Due to the leaky nature of these new blood vessels, there is an increase in the interstitial fluid pressure and flow. Dr. Shieh notes that current research approaches and therapies are not designed for targeting, addressing or understanding these physiological changes. The procedure published in JoVE demonstrates a better way to measure and understand the effects of interstitial fluid flow on tumor cells.

To mimic this physiological process, cells are embedded in a collagen matrix and pressure is applied to the liquid environment. This pressure causes the liquid to flow around the cell, mimicking in vivo conditions of a developing tumor. This allows scientists to study tumor growth and evaluate potential new therapies on cells in culture systems that more closely resemble physiological conditions.

Dr. Shieh hopes that publication of this article in JoVE's video format will bring more awareness to the study of interstitial fluid flow in tumor cells and that it will demonstrate an accessible system to study the phenomenon. He emphasizes, "For many new techniques, even when accompanied by a detailed text protocol, it is very difficult for someone to pick up the procedure and correctly perform the assay. Tremendous expertise and hours of practice are needed to successfully complete this procedure. This multimedia publication format helps demonstrate the finesse required to perform this technique."


'/>"/>
Contact: Neal Moawed
neal.moawed@jove.com
617-245-0137
The Journal of Visualized Experiments
Source:Eurekalert  

Related medicine news :

1. Fisnar Launches QuantX™ Fluid Dispensing System
2. Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases
3. New method to find novel connections from gene to gene, drug to drug and between scientists
4. Wayne State develops better understanding of memory retrieval between children and adults
5. Feces fossils lend new insights into connection between Native-Americans, diabetes
6. New technique reveals cross-talk between 2 essential cellular processes
7. Strong communication between brain and muscle requires both having the protein LRP4
8. New evidence for link between obesity and circle of friends
9. Wayne State University researcher seeks to understand link between obesity, flu severity
10. The Alzheimer’s Caregiver™ - Bridges the Gap between Research and Care
11. The Alzheimer’s Caregiver™ Offers a New Educational Concept of Care That Bridges the Gap between Research and Caregiving
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the fluid between cells affects tumors
(Date:2/19/2017)... ... February 19, 2017 , ... Braun Industries will be participating as an ... event will take place February 23-25, 2017 at the Calvin L. Rampton Salt Palace ... with three new ambulances on display. , “JEMS is a leader ...
(Date:2/19/2017)... ... 2017 , ... Orbita, Inc., a leading provider ... Healthwise ® at HIMSS 2017 to showcase a breakthrough in remote ... technology and services, will demonstrate a voice-powered knowedge assistant based on Orbita ...
(Date:2/18/2017)... ... ... Butler Mobility invited Ken Matthews to visit its manufacturing facility and showroom to ... with the safety and reliability of the Stannah Stairlift as well as with the ... by Ken Matthews can be heard on News Radio WHP 580 weekdays from 3:00 ...
(Date:2/18/2017)... ... February 18, 2017 , ... ProParagraph ... Pixel Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line FCPX project ... Users can pick and choose from hand-crafted trend-setting designs with smooth animations ...
(Date:2/17/2017)... Murfreesboro, TN (PRWEB) , ... February 17, 2017 ... ... EHR mobility has not kept pace. Enovate Medical has introduced an innovative workstation ... 20 years of supporting nurses, the Encore Mobile EHR Workstation offers a lightweight, ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... AMSTERDAM , Feb. 17, ... connected health offerings at the  ...  (NYSE: PHG,AEX: PHIA), a global ... a broad range of population ... personal health solutions, fully integrated in a ...
(Date:2/16/2017)... 2017 Absorption Systems, a global leader in ... pleased to announce that its Chief Operating Officer, ... winner of the 2017 Executive Management Award. The award ... driven executives for their creative management vision, leadership philosophy, ... and celebration is on March 8, 2017 at the ...
(Date:2/16/2017)... , Feb. 16, 2017 The global preparative ... 7.88 billion by 2021 from USD 5.49 billion in ... On the basis of type, the preparative and process ... chromatography. In 2016, the process chromatography segment is expected ... preparative and process chromatography. Growth in this segment can ...
Breaking Medicine Technology: