Navigation Links
How the fluid between cells affects tumors
Date:7/25/2012

July 25, 2012

There are many factors that affect tumor invasion, the process where a tumor grows beyond the tissue where it first developed. While factors like genetics, tissue type and environmental exposure affect tumor metastasis and invasion, physical forces like fluid flow remain a poorly understood component of tumor invasion. A new video article in JoVE, the Journal of Visualized Experiments, describes a novel procedure that allows researchers to study and test the microenvironment of a growing tumor. The technique is valuable because it allows scientists to assay tumor invasion attributable to extracellular fluid flow in vitro and better understand the effects of such physical changes on a tumor. The study focuses specifically on a type of extracellular fluid called interstitial fluid, which flows between cells in a tissue. This procedure is a significant first step to develop an in vitro system that better mimics what happens within a growing tumor in the patient.

"Our goal is to understand how physical forces affect how tumor cells behave. By understanding factors influencing why a tumor does or does not spread, we will have a much better understanding of which therapies will affect the tumor," said the article's author Dr. Adrian Shieh of Drexel University.

As tumors grow, they promote angiogenesis, or growth of new blood vessels, within the tumor itself and the surrounding tissue. Due to the leaky nature of these new blood vessels, there is an increase in the interstitial fluid pressure and flow. Dr. Shieh notes that current research approaches and therapies are not designed for targeting, addressing or understanding these physiological changes. The procedure published in JoVE demonstrates a better way to measure and understand the effects of interstitial fluid flow on tumor cells.

To mimic this physiological process, cells are embedded in a collagen matrix and pressure is applied to the liquid environment. This pressure causes the liquid to flow around the cell, mimicking in vivo conditions of a developing tumor. This allows scientists to study tumor growth and evaluate potential new therapies on cells in culture systems that more closely resemble physiological conditions.

Dr. Shieh hopes that publication of this article in JoVE's video format will bring more awareness to the study of interstitial fluid flow in tumor cells and that it will demonstrate an accessible system to study the phenomenon. He emphasizes, "For many new techniques, even when accompanied by a detailed text protocol, it is very difficult for someone to pick up the procedure and correctly perform the assay. Tremendous expertise and hours of practice are needed to successfully complete this procedure. This multimedia publication format helps demonstrate the finesse required to perform this technique."


'/>"/>
Contact: Neal Moawed
neal.moawed@jove.com
617-245-0137
The Journal of Visualized Experiments
Source:Eurekalert  

Related medicine news :

1. Fisnar Launches QuantX™ Fluid Dispensing System
2. Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases
3. New method to find novel connections from gene to gene, drug to drug and between scientists
4. Wayne State develops better understanding of memory retrieval between children and adults
5. Feces fossils lend new insights into connection between Native-Americans, diabetes
6. New technique reveals cross-talk between 2 essential cellular processes
7. Strong communication between brain and muscle requires both having the protein LRP4
8. New evidence for link between obesity and circle of friends
9. Wayne State University researcher seeks to understand link between obesity, flu severity
10. The Alzheimer’s Caregiver™ - Bridges the Gap between Research and Care
11. The Alzheimer’s Caregiver™ Offers a New Educational Concept of Care That Bridges the Gap between Research and Caregiving
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the fluid between cells affects tumors
(Date:1/20/2017)... ... January 20, 2017 , ... D R Burton ... (OPEP) device, was featured in a study indicating superior performance against competitive products ... “Analysis of Three Oscillating Positive Expiratory Pressure Devices During Simulated Breathing“ was published ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Land of More and More”: ... issue of world hunger, and shares the simple and achievable answer. “The Land of ... member of the Fairview Missionary Church in Angola, Indiana where he works with the ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... Next week ... will be repealed by Congressional political games that circumvent health needs of over 30 ... Rally” capture the human anxieties and needs government public servants were suppose to prioritize. ...
(Date:1/19/2017)... ... January 19, 2017 , ... LabRoots , ... from around the world, announces the launch of its newly redesigned website. The ... to research breakthroughs and trending news, vital information on upcoming virtual events and ...
(Date:1/19/2017)... ... January 19, 2017 , ... WholeHealth is announcing their ... Alexander Paziotopoulos, Andrew Petersen and Trish Henrie-Barrus will be present Saturday and Sunday ... recovery program. , “We know it’s easy to get carried away when ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... NEW YORK , Jan. 19, 2017 ... ... Forecast 2016-2026: Opportunities for Leading Companies – our new ... new report discusses issues and events affecting the Alzheimer,s ... qualitative analyses to answer these key questions: - How ...
(Date:1/19/2017)... 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ), ... dysfunction, today announced new additions to its senior leadership ... Medical Officer, and Daniel Geffken as interim ... Jim Carr , Pharm.D. has been promoted to Chief ... to welcome Doug and Daniel to our management team, ...
(Date:1/19/2017)... 2017 Accuray Incorporated (Nasdaq: ARAY ... continue to set the bar for excellence in customer ... user satisfaction rating among radiation treatment delivery systems in ... Market Intelligence Briefing™. The most recent ratings trend also ... industry peers for 11 of the past 12 quarters. ...
Breaking Medicine Technology: