Navigation Links
How the brain's daily clock controls mood: A new project
Date:4/24/2012

ANN ARBOR, Mich.A math professor at the University of Michigan will lead an international, $1 million project examining the links between bipolar disorder and abnormalities in the circadian, or daily, rhythms of a mammal's internal clock.

In humans, this grain-of-rice-sized timepiece is a cluster of 20,000 neurons right behind the eyes. It's called the suprachiasmatic nucleas (SCN) of the brain's hypothalamus, and it is responsible for keeping our bodies in synch with our planet's 24-hour day.

Scientists believe it's off kilter in patients with bipolar disorder. Some of the genes implicated in the disease are the same ones that regulate the biological clock. The common treatment drug lithium is known to change the period of that clock, and when manic patients are forced to stay on a 24-hour schedule, many experience a reprieve from the episode, said principal investigator Daniel Forger, an associate professor in the U-M Department of Mathematics.

Exactly how the brain's clock controls mood remains a mystery, though. This new project aims to change that through complex mathematical modeling and experiments involving mice.

"We're going to continuously monitor the state of the animals' internal clock. We'll watch it tick, use mathematics to understand its function and test how it controls mood," Forger said.

The researchers will examine the brains of depressed and normal mice and look for abnormal electrical activity. The researchers aim to determine what state of the clock region corresponds with different moods in the animals.

"We're going to learn an awful lot about the circadian clock, which could also, in addition to depression, play a role in Alzheimer's, cancer and heart attacks," Forger said.


'/>"/>
Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1

Related medicine news :

1. Strength Training May Give Boost to Seniors Brains
2. Our brains on food: From anorexia to obesity and everything in between
3. Infants Faces Trigger Caregiving Impulse in Adults Brains
4. Spring Break Boozing May Put Young Brains at Risk
5. Study reveals how anesthetic isoflurane induces Alzheimers-like changes in mammalian brains
6. Smoking May Be Especially Tough on Mens Brains
7. Why Human Brains Are Smarter Than Chimp Brains
8. Adolescents brains respond differently than adults when anticipating rewards
9. Bat brains parse sounds for multitasking
10. Thinner Brains Could Signal Alzheimers, Study Suggests
11. Century-old brains may hold future of treatment for mentally ill, Indiana University pathologist says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... ... MadgeTech will be showcasing its line of data logging products , ... MadgeTech headquarters. With products sold in more than 100 countries around the world, MadgeTech ... , In 2012, NASA strategically set up 17 RHTemp101A MadgeTech data loggers around ...
(Date:5/26/2016)... ... May 26, 2016 , ... An April Gallup survey found rising health care ... of Sun Health Senior Living (SHSL) may not share those same worries ... prescription copays for the year, while holding the line on increasing their contributions, including ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership of ... today announced the organization has earned its ISO 13485 certification, indicating the company’s ... with all rules and policies associated with ISO quality standard 13485. , ...
(Date:5/26/2016)... ... 2016 , ... North Cypress Medical Center hosted its 9th Annual ... With the help of community partners, the event organizers raised $45,000 for the ... service members and their families through health, wellness, and therapeutic support. , A ...
(Date:5/26/2016)... FL (PRWEB) , ... May 26, 2016 , ... The ... of events featuring guest speaker Dr. Adonis Maiquez MD, ABAARM. Dr. Adonis , ... and Regenerative Medicine, and a member of the Institute for Functional Medicine. , He ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25, 2016 Digital Health Dialog, LLC ... by the US Patent and Trademark Office of ... proprietary processes for electronic opt-­in and processing of ... programs, HIPAA compliance and otherwise. Logo - ... "Our technology allows for individuals to ...
(Date:5/24/2016)... 24, 2016 Niederländische Chirurgen ... die es Ärzten erlaubt, ihre Expertise weltweit zu ... kombiniert Live Streaming mit einer Instant-Messaging-Funktion und der ... Mediziner in Europa, Afrika, Asien und den ... die Plattform registriert. Information und Weiterbildung   ...
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
Breaking Medicine Technology: