Navigation Links
How the brain makes memories: Rhythmically!
Date:10/3/2011

, said Mehta, "spike frequency refers to how fast the spikes come. Ten spikes could be delivered at a frequency of 100 spikes a second or at a frequency of one spike per second."

Until now, researchers had been unable to conduct experiments that simulated more naturally occurring levels. But Mehta and co-author Arvind Kumar, a former postdoctoral fellow in his lab, were able to obtain these measurements for the first time using a sophisticated mathematical model they developed and validated with experimental data.

Contrary to what was previously assumed, Mehta and Kumar found that when it comes to stimulating synapses with naturally occurring spike patterns, stimulating the neurons at the highest frequencies was not the best way to increase synaptic strength.

When, for example, a synapse was stimulated with just 10 spikes at a frequency of 30 spikes per second, it induced a far greater increase in strength than stimulating that synapse with 10 spikes at 100 times per second.

"The expectation, based on previous studies, was that if you drove the synapse at a higher frequency, the effect on synaptic strengthening, or learning, would be at least as good as, if not better than, the naturally occurring lower frequency," Mehta said. "To our surprise, we found that beyond the optimal frequency, synaptic strengthening actually declined as the frequencies got higher."

The knowledge that a synapse has a preferred frequency for maximal learning led the researchers to compare optimal frequencies based on the location of the synapse on a neuron. Neurons are shaped like trees, with the nucleus being the base of the tree, the dendrites resembling the extensive branches and the synapses resembling the leaves on those branches.

When Mehta and Kumar compared synaptic learning based on where synapses were located on the dendritic branches, what they found was significant: The optimal frequency for inducing synaptic lear
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Yawning May Help the Brain Chill Out
2. Brain Continues to Develop Beyond Adolescence
3. Stanford brain imaging study shows physiological basis of dyslexia
4. Louisiana State University Health Sciences Center research discovers key to survival of brain cells
5. How normal cells become brain cancers
6. New modeling of brains circuitry may bring better understanding of Parkinsons disease
7. Could Too Little Vitamin B-12 Shrink the Aging Brain?
8. Could targeting a virus treat a common pediatric brain tumor?
9. Some brain wiring continues to develop well into our 20s: U of A study
10. The disinhibited brain
11. Buyer beware: Advertising may seduce your brain, UCLA researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, Sigma Theta Tau ... of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key nurse leaders ... Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of Human Resources ...
(Date:7/31/2015)... ... July 31, 2015 , ... Precision Aesthetics is New ... It was also the first provider of Exilis non-surgical fat reduction in New ... procedures it has attracted a large International clientele. Many patients travel to New ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... The 2nd ... Church Park in Downtown Memphis on October 3, 2015. The Ride to Fight On ... on cancer research between Methodist Healthcare, The West Clinic and The University of Tennessee ...
(Date:7/31/2015)... Jacksonville, FL (PRWEB) , ... July 31, 2015 ... ... has announced an important workshop at its new True North Conference Center. The ... attend so that the Jacksonville community may be more aligned in the effort ...
(Date:7/31/2015)... ... July 31, 2015 , ... M3 USA MDLinx.com, source of ... three new Board Exam Courses. , The additions of Gastroenterology, Pulmonology and Allergy/Immunology ... from MDLinx makes preparing for the exam easy and painless. MDLinx offers thousands ...
Breaking Medicine News(10 mins):Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3
... a vascular surgeon at London's Middlesex Hospital, advices passengers, who fly ... death of a woman on board an airliner, while she was ... that long flights can be fatal to many people. ,Dr. ... over reacting.,He says that clot formation can also occur if a ...
... found inside the mouth can lead to oral cancer in ... the patches could become cancerous or not.,Scientists at the University ... leukoplakia, as the patches are known, can be cured and ... in the cells that make up the patches is the ...
... are too small to be picked up by a mammogram, ... candidate for breast cancer. But to offset this problem, scientists ... by Dr. Saraswathi Sukumar, have devised a new method of ... method called ductal lavage. Ductal lavage, involves "washing" breast milk ...
... may opt for mastectomy over breast-conserving lumpectomy if they test ... on Monday. ,About 5% to 10% of all breast ... of these cancers are linked to mutations or alterations in ... carriers have a 55% to 85% risk of breast cancer ...
... tubes in young children who develop fluid in the ears ... new research. ,Currently there are two reasons for ear ... the inner ear cavity of an otherwise healthy child. Doctors ... the second case, children could face long-term developmental impairment. ...
... say that wound healing in depressed people is four times ... find a place in the latest issue of the journal, ... effects on the rate of wound healing, according to the ... affect the immune system, which may keep a wound from ...
Cached Medicine News:Health News:Researchers urge caution in using ear tube surgery 2Health News:Researchers urge caution in using ear tube surgery 3
(Date:7/30/2015)... , July 30, 2015  Today we bring you a special edition of #MedicareMonday ... remind you about some of our Medicare resources and continue highlighting the success of ... Check out our latest infographics and videos here: ... ... ...
(Date:7/30/2015)... 2015  Amgen (NASDAQ: AMGN ) today announced the ... of Warburg Pincus LLC, to the Amgen Board of Directors. ... Hassan and the deep, global experience he brings in ... A. Bradway , chairman and chief executive officer of Amgen. "Fred,s ... Amgen well." Mr. Hassan has been Partner and ...
(Date:7/30/2015)... New York , July 30, 2015 ... of its latest report titled, "Continuous Glucose Monitoring Systems ... 2020". According to the report, the global continuous glucose ... in 2014 and is expected to reach US$ 788.4 ... the forecast period, 2015 to 2020. Global ...
Breaking Medicine Technology:Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4
... 3 Tapestry,Pharmaceuticals, Inc. (Nasdaq: TPPH ) announced ... multi-center study of TPI 287 in patients with,advanced pancreatic ... the,activity of TPI 287 in various tumor types: the ... hormone refractory prostate cancer. "Currently available taxanes are ...
... Effective for Menopausal ... Women, ... the 2007 Annual Meeting of the North American Menopause Society (NAMS),revealed that ... severe hot flashes associated with,menopause. Additional data presented at the meeting found ...
Cached Medicine Technology:Tapestry Initiates Phase 2 Trial of TPI 287 for the Treatment of Advanced Pancreatic Cancer 2Tapestry Initiates Phase 2 Trial of TPI 287 for the Treatment of Advanced Pancreatic Cancer 3Tapestry Initiates Phase 2 Trial of TPI 287 for the Treatment of Advanced Pancreatic Cancer 4Tapestry Initiates Phase 2 Trial of TPI 287 for the Treatment of Advanced Pancreatic Cancer 5New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes 2
... state-of-the-art electronic medical record the development of ... a proven, comprehensive electronic medical record designed ... at the point of care and to ... through the Internet. AmkaiCharts chronicles patient history, ...
... Medical Systems Information Technologies ... for yourself how it's ... Office - Practice Management ... can simplify your office ...
... The ReSeeVit 3Z slit lamp is designed ... This video ready slit lamp offers the ... another addition to the ReSeeVit family of ... on the market to capture clear, crisp ...
The AIA-600 II has become the new standard in benchtop immunoassay analyzers....
Medicine Products: