Navigation Links
How the brain makes memories: Rhythmically!
Date:10/3/2011

, said Mehta, "spike frequency refers to how fast the spikes come. Ten spikes could be delivered at a frequency of 100 spikes a second or at a frequency of one spike per second."

Until now, researchers had been unable to conduct experiments that simulated more naturally occurring levels. But Mehta and co-author Arvind Kumar, a former postdoctoral fellow in his lab, were able to obtain these measurements for the first time using a sophisticated mathematical model they developed and validated with experimental data.

Contrary to what was previously assumed, Mehta and Kumar found that when it comes to stimulating synapses with naturally occurring spike patterns, stimulating the neurons at the highest frequencies was not the best way to increase synaptic strength.

When, for example, a synapse was stimulated with just 10 spikes at a frequency of 30 spikes per second, it induced a far greater increase in strength than stimulating that synapse with 10 spikes at 100 times per second.

"The expectation, based on previous studies, was that if you drove the synapse at a higher frequency, the effect on synaptic strengthening, or learning, would be at least as good as, if not better than, the naturally occurring lower frequency," Mehta said. "To our surprise, we found that beyond the optimal frequency, synaptic strengthening actually declined as the frequencies got higher."

The knowledge that a synapse has a preferred frequency for maximal learning led the researchers to compare optimal frequencies based on the location of the synapse on a neuron. Neurons are shaped like trees, with the nucleus being the base of the tree, the dendrites resembling the extensive branches and the synapses resembling the leaves on those branches.

When Mehta and Kumar compared synaptic learning based on where synapses were located on the dendritic branches, what they found was significant: The optimal frequency for inducing synaptic lear
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Yawning May Help the Brain Chill Out
2. Brain Continues to Develop Beyond Adolescence
3. Stanford brain imaging study shows physiological basis of dyslexia
4. Louisiana State University Health Sciences Center research discovers key to survival of brain cells
5. How normal cells become brain cancers
6. New modeling of brains circuitry may bring better understanding of Parkinsons disease
7. Could Too Little Vitamin B-12 Shrink the Aging Brain?
8. Could targeting a virus treat a common pediatric brain tumor?
9. Some brain wiring continues to develop well into our 20s: U of A study
10. The disinhibited brain
11. Buyer beware: Advertising may seduce your brain, UCLA researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... PA (PRWEB) September 18, 2014 ... announces the launch of Good Neighbor Pharmacy University, ... access information that will educate and empower pharmacy ... “As the healthcare industry continues to evolve, Good ... as we deliver resources and tools to help ...
(Date:9/18/2014)... London. (PRWEB) September 18, 2014 CD-adapco, ... Aided Engineering software, today announced its new partnership with ... utilizing the CD-adapco simulation tool, STAR-CCM+® in the design ... announced its participation in the 35th America’s Cup taking ... edition of the America’s Cup is sustainability, the set ...
(Date:9/18/2014)... of college-educated parents eat more vegetables and drink less ... of British Columbia. But it,s still not enough, the ... falling short when it comes to eating healthier at ... an indicator of socioeconomic status, may inform a child,s ... parents completed some post-secondary education were 85 per cent ...
(Date:9/18/2014)... German . ... won the ,International Space Station Research Competition, with their ... the scientists will see the International Space Station crew ... crystallizing two proteins of the hepatitis C virus under ... International Space Station is scheduled to lift off from ...
(Date:9/18/2014)... Cary, NC (PRWEB) September 18, 2014 Relias ... the health and human services markets, today announced it has ... the fastest growing private companies in America. , In the ... growth, and moved up almost 2,000 spots on the Inc. ... in 2012. , “The industries we serve continue ...
Breaking Medicine News(10 mins):Health News:Good Neighbor Pharmacy University Keeps Pharmacists Ahead of the Curve 2Health News:Ben Ainslie Racing Using STAR-CCM+ Simulation Software to Design 35th America’s Cup Racing Boat 2Health News:Kids eat better if their parents went to college 2Health News:Hepatitis C virus proteins in space 2Health News:Relias Learning Named to Inc. 5000 List for Second Consecutive Year 2
... WASHINGTON, Sept. 26 HHS Secretary Mike,Leavitt today announced ... eligible low income homeowners and renters meet home energy ... are expected to,provide states with heating assistance for the ... from the cold," Secretary Leavitt said. "These,funds will put ...
... Committee of,Massachusetts (AAC) today presented written and oral testimony ... of bills having to do with privacy,informed consent and ... in support of H2276,the Public Health Privacy Act, urging ... the public health system,s interest in obtaining health,information for ...
... SAN DIEGO and MCLEAN, Va., Sept. 26 ... today that it,has won a new $38 million ... the,Theater Medical Information Program -- Joint (TMIP-J). ... base,period of performance and three one-year options. The ...
... Sept. 26 SEIU United Healthcare,Workers-West and ... relief seeking,to stop Tenet Healthcare Corp. from ... employees, including registered nurses,pharmacists, licensed vocational nurses, ... certified nursing,assistants. Workers represented by the ...
... of its ongoing dedication to,serving military members and their ... sponsor of Fleet Week San Diego, a,month-long celebration of ... its 11th year on Sept. 17 and continues until,Oct. ... historical, economic and,cultural importance of military personnel in San ...
... Residents from Metropolitan,Jewish Geriatric Center recently participated in ... Yom Kippur. (Photo: http://www.newscom.com/cgi-bin/prnh/20070926/NYW148 ) ... (a rooster for a man and a,hen for ... while reciting a prayer.,This ritual is meant to ...
Cached Medicine News:Health News:HHS Provides Over $131 Million In Energy Assistance 2Health News:AIDS Action Committee Testifies to Protect the Privacy of People Seeking Healthcare in Massachusetts 2Health News:SAIC Selected to Support the U.S. Military Theater Medical Information Program-Joint 2Health News:Unions File Charges Against Tenet Healthcare Corporation, Three Northern California Hospitals 2Health News:TriWest On Deck to Support Fleet Week San Diego 2
(Date:9/18/2014)... 2014 After 6 months of careful ... here - the new programme for the next Cool Chain ... our global Cool Chain series, has just been released! ... As the lines between supply chain, logistics, QA and ... that is broad and yet specific, focused and yet accessible, ...
(Date:9/18/2014)... Calif. , Sept. 18, 2014   ... ), a biopharmaceutical company leading the discovery and ... it has initiated its ATHENA natural history of ... life-threatening genetic kidney disease with no approved therapy. ... natural decline of renal function markers such as ...
(Date:9/18/2014)... , Sept. 18, 2014  RXi Pharmaceuticals ... biotechnology company focused on discovering, developing and ... needs using RNA-targeted technologies, today announced that the ... Geert Cauwenbergh , will present at ... Conference on Wednesday, September 24, 2014 at ...
Breaking Medicine Technology:Europe's Biggest and Longest-Running Gathering of Life Sciences Logistics, Supply Chain & QA Professionals 2Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 2Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 3Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 4Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 5Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 6RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 2RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 3
... MADISON, N.J., March 28, 2011 Quest Diagnostics Incorporated ... of diagnostic testing, information and services, announced today it ... subsidiary, Spark Acquisition Corporation, for all of the outstanding ... (Nasdaq: CRA ), one of the world,s ...
... (Nasdaq: VRUS ) today announced that it will ... Study of the Liver (EASL) on Saturday, April 2, 2011 ... Pharmasset,s progress on the programs that are the subject of ... a simultaneous webcast of this event via the internet, log ...
Cached Medicine Technology:Quest Diagnostics Commences Tender Offer for Acquisition of Celera 2Quest Diagnostics Commences Tender Offer for Acquisition of Celera 3Pharmasset to Webcast an Investor Event From the EASL Meeting 2Pharmasset to Webcast an Investor Event From the EASL Meeting 3
... device for the qualitative detection of drug or ... device can detect up to nine of the ... minutes and requires only a few drops of ... maximize convenience and ease of use. TOX/See features ...
... TOX/See™ is a 1-step, hand-held, point-of-care device ... metabolites in human urine. The TOX/See device ... commonly abused drugs in 3 to 8 minutes ... Each TOX/See cassette is individually packaged to maximize ...
... TOX/See™ is a 1-step, hand-held, point-of-care device ... metabolites in human urine. The TOX/See device ... commonly abused drugs in 3 to 8 minutes ... Each TOX/See cassette is individually packaged to maximize ...
... device for the qualitative detection of drug or ... device can detect up to nine of the ... minutes and requires only a few drops of ... maximize convenience and ease of use. TOX/See features ...
Medicine Products: