Navigation Links
How some cancers 'poison the soil' to block metastasis
Date:4/30/2013

Medical School and the University of Bergen, Norway, contributed to this study.

Exploit What Nature Has Provided

Scientists have known that all primary tumors do not metastasize, but no one knew what prevented cancer's spread in these "metastasis incompetent" tumors. This new study was conducted to uncover that very mechanism.

"The novel idea was that if we can learn why these certain cancers don't spread, and then we could leverage that knowledge to block metastatic tumors," says Dr. Mittal.

Scientists don't understand why some tumors wouldn't "want" to spread. It goes against their "job description," says Dr. Mittal. He theorizes that metastasis occurs when the barriers that the body throws up to protect itself against cancer fail. But there are some tumors in which some of the barriers may still be intact. "So that suggests those primary tumors will continue to grow, but that an innate protective barrier still exists that prevents them from spreading and invading other organs," says Dr. Mittal.

What the researchers found is that, like typical tumors, metastasis incompetent tumors also send out signaling molecules that establish what is known as the "pre-metastatic niche" in distant organs. These niches comprised of bone marrow cells and various growth factors have been described previously by others including Dr. Mittal as the fertile "soil" that the disseminated cancer cell "seeds" grow in.

Weill Cornell's Dr. Ral Catena, a postdoctoral fellow in Mittal's laboratory and lead author of the Cancer Discovery study, found an important difference between the tumor types. Metastatic-incompetent tumors systemically increased expression of Tsp-1, a molecule known to fight cancer growth. Importantly, increased Tsp-1 production was found specifically in the bone marrow myeloid cells that comprise the metastatic niche. These results were striking, because for the first time the bone marrow-derived my
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Decoded: Molecular messages that tell prostate and breast cancers to spread
2. UK study shows potential new way to detect colorectal and other cancers
3. Non-Melanoma Skin Cancers Tied to Risk for Other Cancers
4. New radiotherapy approach reduces symptoms of dry mouth in patients with head and neck cancers
5. Screening breast ultrasound detects cancers missed on mammography in women with dense breasts
6. LSUHSC research reveals Rx target for HPV, Hep C and related cancers
7. Fox Chase researchers find some lung cancers linked to common virus
8. UCLA researchers find potential link between auto pollution, some childhood cancers
9. Targeted toxin active in platinum-resistant ovarian cancers
10. Wake-Up Cigarette May Raise Risk for Lung, Mouth Cancers
11. Immortality gene mutation identifies brain tumors and other cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... A recent survey ... number of Hispanics believe people can positively affect their diabetes, few look beyond ... said making diet changes was important. Far fewer participants mentioned the need for ...
(Date:8/3/2015)... ... August 03, 2015 , ... Novatus, Inc. today ... management solution, as well as announced the date of its next major release. ... of contract management tasks as well as enhancements to the customer experience. ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... to Ahjumawi Lava Springs, California’s northernmost and among its least visited State Parks. ... water aquifers, whose main outflow is at Ahjumawi Lava Springs, part of the ...
(Date:8/3/2015)... ... August 03, 2015 , ... Illinois Health & Science (IHS) has completed ... The acquisition includes all of IBAM NA’s cyclotron sites and research and development facilities. ... regionally located business, as well as a large manufacturing hub in Noblesville, Indiana,” said ...
(Date:8/3/2015)... Spring, MD (PRWEB) , ... August 03, 2015 , ... ... the addition of a new associate podiatrist, creating the largest medical practice in the ... foot and ankle medicine. FASMA operates 21 locations with 33 doctors. , Dr. Hetal ...
Breaking Medicine News(10 mins):Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 4Health News:Novatus Unveils Milestone Software Release 2Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 2Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 3Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 4Health News:Illinois Health & Science Expands Nuclear Medicine Footprint With Purchase of IBA Molecular North America, Inc. 2Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 2Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 3Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 4
... BOSTON Ask anyone who suffers from migraine headaches what ... to hear "go into a dark room." And although ... reason why has been unclear. Now scientists at ... visual pathway that underlies sensitivity to light during migraine in ...
... information pathways converge in brain , SUNDAY, Jan. 10 ... exacerbates the already debilitating pain of migraines, even in ... 10 in Nature Neuroscience reveals how visual ... this phenomenon. , Although the findings are unlikely to ...
... ... treatment, Francisco Peinado got plundered by credit card debt and endless collection calls. However, a ... a casualty of medical bankruptcy, which based on a New York Times article, is growing. ... (PRWEB) January 10, ...
... ... Kadrich’s Leading Security Book Endpoint Security, , ... San Jose, CA (PRWEB) January 10, 2010 -- The Security ... announced its support for recently appointed White House cyber-security “czar” Howard Schmidt. A ...
... Mark5inc ... requires to know about attaining whiter and brighter teeth. , ... (PRWEB) January 2, 2010 -- We all were born ... boast our first set of teeth to the world, which were temporary. As we grew, ...
... interpersonal relationships stems weight gain, study finds ... psychotherapy program may work better than traditional health ... obesity from becoming excessively fatter, researchers report. ... by targeting the underlying social and interpersonal difficulties ...
Cached Medicine News:Health News:Study explains why light worsens migraine headaches 2Health News:Study explains why light worsens migraine headaches 3Health News:Why Light Hurts During Migraines 2Health News:Why Light Hurts During Migraines 3Health News:Cancer Patient's Medical Debt Ends in Brother's Credit Card Debt Settlement Victory Over Bankruptcy 2Health News:Cancer Patient's Medical Debt Ends in Brother's Credit Card Debt Settlement Victory Over Bankruptcy 3Health News:Cancer Patient's Medical Debt Ends in Brother's Credit Card Debt Settlement Victory Over Bankruptcy 4Health News:Cancer Patient's Medical Debt Ends in Brother's Credit Card Debt Settlement Victory Over Bankruptcy 5Health News:The Security Consortium Announces Support for White House Cyber Chief Schmidt 2Health News:The Security Consortium Announces Support for White House Cyber Chief Schmidt 3Health News:The Security Consortium Announces Support for White House Cyber Chief Schmidt 4Health News:Mark5inc Teeth Whitening Resource Is Presented To Web 2
(Date:8/3/2015)... , Aug. 3, 2015  Depomed, Inc. (NASDAQ: ... Horizon Pharma plc,s (NASDAQ: HZNP ) ("Horizon") announcement ... Directors ("Depomed Board") set a record date to determine ... The Depomed Board will review the request ... received today and contains the information required under Depomed,s ...
(Date:8/3/2015)... NEW YORK , August 3, 2015 /PRNewswire/ ... report published by Persistence Market Research "Global Market ... to Witness Highest Growth by 2022", ... at US$15 Bn by the end of 2015 and ... 6.8% from 2015 to 2022, to account for ...
(Date:8/3/2015)... SPRINGS, Florida , August 3, 2015 ... development agreements between biotech companies, military surgical ... solutions & therapies with regards to severe ... positive clinical enhancements for regenerative medicine and ... recent developments, partnerships and advancements in focus ...
Breaking Medicine Technology:Depomed Comments on Horizon Pharma Announcement 2Depomed Comments on Horizon Pharma Announcement 3Depomed Comments on Horizon Pharma Announcement 4Depomed Comments on Horizon Pharma Announcement 5Depomed Comments on Horizon Pharma Announcement 6Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 2Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 3Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 4Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 2Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 3Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 4Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 5Biotech Advancements Coupled with Collaborative Partnerships Focus on Developing Orphan Drug Products & Treatments for Critical-Care Patients With Severe Wound Conditions 6
... (OTCQB: SCLR) announced today that it has launched several ... drug delivery platform, Controlled Delivery Technology ... under various private label brands across the country at ... product has been designed to deliver the full nutritional ...
... Feb. 16, 2012   Remedy Informatics, the leading provider ... Translational research, announced that its Founder and CEO, Gary ... R&D Informatics and Knowledge Management Track on Tuesday, Feb. ... 22 at Molecular Med TRI-CON Feb. 19-23, 2012, in ...
Cached Medicine Technology:SCOLR Pharma, Inc. Launches Cutting Edge Nutritional Products at Major Retailers in 2012 2Remedy Informatics CEO, Gary Kennedy, to Speak at Molecular Med TRI-CON 2Remedy Informatics CEO, Gary Kennedy, to Speak at Molecular Med TRI-CON 3
With the Symphony family of Pacemakers, Ela presents the most advanced technology on the market. Symphony, lighter than a passport, will take your patients further, offering fast follow-up, using new...
... Measuring System delivers precise and accurate Measurements! ... receiving a better examination when they see ... equipment. ,User Friendly - after only 5 ... can become very proficient in the operation ...
Gentle curve facilitates less traumatic removal from eye. Increased length ideal for myopic eyes...
Curved Cannula for probing and irrigating lacrimal duct. 0.80mm (21 G)...
Medicine Products: