Navigation Links
How some cancers 'poison the soil' to block metastasis
Date:4/30/2013

Medical School and the University of Bergen, Norway, contributed to this study.

Exploit What Nature Has Provided

Scientists have known that all primary tumors do not metastasize, but no one knew what prevented cancer's spread in these "metastasis incompetent" tumors. This new study was conducted to uncover that very mechanism.

"The novel idea was that if we can learn why these certain cancers don't spread, and then we could leverage that knowledge to block metastatic tumors," says Dr. Mittal.

Scientists don't understand why some tumors wouldn't "want" to spread. It goes against their "job description," says Dr. Mittal. He theorizes that metastasis occurs when the barriers that the body throws up to protect itself against cancer fail. But there are some tumors in which some of the barriers may still be intact. "So that suggests those primary tumors will continue to grow, but that an innate protective barrier still exists that prevents them from spreading and invading other organs," says Dr. Mittal.

What the researchers found is that, like typical tumors, metastasis incompetent tumors also send out signaling molecules that establish what is known as the "pre-metastatic niche" in distant organs. These niches comprised of bone marrow cells and various growth factors have been described previously by others including Dr. Mittal as the fertile "soil" that the disseminated cancer cell "seeds" grow in.

Weill Cornell's Dr. Ral Catena, a postdoctoral fellow in Mittal's laboratory and lead author of the Cancer Discovery study, found an important difference between the tumor types. Metastatic-incompetent tumors systemically increased expression of Tsp-1, a molecule known to fight cancer growth. Importantly, increased Tsp-1 production was found specifically in the bone marrow myeloid cells that comprise the metastatic niche. These results were striking, because for the first time the bone marrow-derived my
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Decoded: Molecular messages that tell prostate and breast cancers to spread
2. UK study shows potential new way to detect colorectal and other cancers
3. Non-Melanoma Skin Cancers Tied to Risk for Other Cancers
4. New radiotherapy approach reduces symptoms of dry mouth in patients with head and neck cancers
5. Screening breast ultrasound detects cancers missed on mammography in women with dense breasts
6. LSUHSC research reveals Rx target for HPV, Hep C and related cancers
7. Fox Chase researchers find some lung cancers linked to common virus
8. UCLA researchers find potential link between auto pollution, some childhood cancers
9. Targeted toxin active in platinum-resistant ovarian cancers
10. Wake-Up Cigarette May Raise Risk for Lung, Mouth Cancers
11. Immortality gene mutation identifies brain tumors and other cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... (PRWEB) July 30, 2014 BuyCBDOnline.co ... infused products, is pleased to announce that it is ... selection of top quality products available for immediate shipping. ... still in it's infancy stages," site founder Jason Liss ... already a wide variety of unique products that are ...
(Date:7/30/2014)... 2014 The Independent Woman , ... holding 5 free financial workshops in the San Francisco ... goal of these workshops is our collective success, linking ... financial empowerment. , These workshops were designed by women, ... successful investor, entrepreneur, and bestselling author (Rich Woman and ...
(Date:7/30/2014)... July 30, 2014 With the ... of personal health expenditure as well as the ... system, China diagnostic reagent industry has been developing ... 90%. In 2013, Chinese in vitro diagnostics market ... came from in vitro diagnostic reagents. , ...
(Date:7/30/2014)... According to the Yeast Infection No More book ... that will help candida sufferers get rid of their ... uncovers to readers the truth about yeast infection and the ... people will discover natural and safe remedies to relieve symptoms ... and irritation of the vagina or vulva. , Vkool ...
(Date:7/30/2014)... 30, 2014 My Clients Plus ... 80 different electronic therapy note templates. Healthcare providers ... other computing devices all while meeting the HIPPA ... electronic medial records (EMR) consist of psychological intake ... essential categories. SOAP and DAP note formats ...
Breaking Medicine News(10 mins):Health News:Delicious, Unique CBD-Rich Hemp Oil Product Debuts from BuyCBDOnline.co 2Health News:Delicious, Unique CBD-Rich Hemp Oil Product Debuts from BuyCBDOnline.co 3Health News:The Independent Woman is Coming to the San Francisco Area in August - Women Helping Women Reach Their Financial Goals 2Health News:The Independent Woman is Coming to the San Francisco Area in August - Women Helping Women Reach Their Financial Goals 3Health News:China Diagnostic Reagent Industry (biochemical, molecular & immunodiagnostic) 2016 Forecasts in New Research Report at ChinaMarketResearchReports.com 2Health News:China Diagnostic Reagent Industry (biochemical, molecular & immunodiagnostic) 2016 Forecasts in New Research Report at ChinaMarketResearchReports.com 3Health News:China Diagnostic Reagent Industry (biochemical, molecular & immunodiagnostic) 2016 Forecasts in New Research Report at ChinaMarketResearchReports.com 4Health News:Yeast Infection No More Book Review Exposes Linda Allen's Guide for Treating Yeast Infection – Vkool.com 2Health News:Yeast Infection No More Book Review Exposes Linda Allen's Guide for Treating Yeast Infection – Vkool.com 3Health News:My Clients Plus Announces Over 80 Online Therapy Notes to Help Healthcare Providers Go Paperless 2
... reports of persistent,recent-onset symptoms linked to ovarian cancer ... full quickly and abdominal bloating -- when,combined with ... detection of,ovarian cancer by 20 percent, according to ... Center published online today in CANCER., Research ...
... inflammatory rheumatic disease, associated with stiffening of the vertrebral ... diagnosed in Germany, but milder forms of the disease ... Dr. Roland R. Wick, with Dr. Elke A. Nekolla, ... Dr. Wolfgang Gssner have conducted a long-term follow-up study ...
... Oral cannabis may even cause increased sensitivity in certain ... -- Oral cannabis (a form of medical marijuana) was ... actually increased sensitivity to some other kinds of discomfort, ... , Their study included 18 healthy women who ...
... might extend the effectiveness of clot-busting tPA, researchers say ... weapon against cancer might also boost stroke patients, survival, ... "wonder drug" against cancers such as chronic myelogenous leukemia ... boost the effectiveness and limit the side effects of ...
... More younger people than before are expected to ... acid in 2008, according to Millennium Research Group, ... Group (MRG),conducted a detailed survey focused on facial ... conference in San Antonio, Texas.,Over 60 US-based dermatologists ...
... $0.96 to $0.97 - - ... - Announces Additional ... Nash Corporation,(Nasdaq: KNSY ) today updated and expanded its previously announced ... to,include earnings per share estimates. In addition, the Company provided an,outlook for ...
Cached Medicine News:Health News:Symptom Screening Plus a Simple Blood Test Equals a 20 Percent Jump in Early Detection of Ovarian Cancer 2Health News:Symptom Screening Plus a Simple Blood Test Equals a 20 Percent Jump in Early Detection of Ovarian Cancer 3Health News:Increased cancer risk following the use of radioactive Radium-224 in the therapy 2Health News:Medical Pot Ineffective as Acute Pain Treatment 2Health News:Cancer Drug Gleevec Could Fight Stroke 2Health News:Cancer Drug Gleevec Could Fight Stroke 3Health News:Younger Patients Seeking More Aesthetic Treatments 2Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 2Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 3Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 4Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 5Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 6Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 7Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 8Health News:Kensey Nash Provides 4th Quarter Fiscal 2008 and Fiscal Year 2009 Guidance 9
(Date:7/30/2014)... July 30, 2014 Company ... programming expertise to big data, aerospace and defense, ... eInfochips, a leading engineering R&D services company, today ... NVIDIA GPU-powered solutions for aerospace and defense ... (HPC), industrial , and visual ...
(Date:7/29/2014)... Israel , July 30, 2014 /PRNewswire/ ... Premier, Stockholm : "IMNP."; "Immune" or ... screening of patients for a Phase II proof of ... bertilimumab in the treatment of moderate to severe bullous ... will receive two bertilimumab infusions, at a dose of ...
(Date:7/29/2014)... Amgen (NASDAQ: AMGN ) today announced financial ... include: , Total revenues increased 11 percent to ... by strong performance across the portfolio, particularly Enbrel ® ... (denosumab) and XGEVA ® (denosumab). , Adjusted ... revenues and a significant increase in the profitability of ...
Breaking Medicine Technology:eInfochips to Develop NVIDIA GPU-powered Solutions for Aerospace and Defense, Medical Imaging, HPC and Visual Computing 2Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 2Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 3Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 4Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 5Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 2Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 3Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 4Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 5Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 6Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 7Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 8Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 9Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 10Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 11Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 12Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 13Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 14Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 15Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 16Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 17Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 18Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 19Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 20Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 21Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 22Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 23Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 24Amgen's Second Quarter 2014 Revenues Increased 11 Percent To $5.2 Billion And Adjusted Earnings Per Share (EPS) Increased 25 Percent To $2.37 25
Khosla Precision and Quality in Medical and Surgical Products....
...
...
To enter, dissect, elevate and smooth the flap. Combined features of Spatula, Dissector and Forceps. - Also available in Titanium...
Medicine Products: