Navigation Links
How some cancers 'poison the soil' to block metastasis
Date:4/30/2013

NEW YORK (April 30, 2013) -- Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are able to generate fertile soil (the microenvironment) in distant organs that promotes cancer's spread. However, this concept does not explain why some tumors do not spread or metastasize.

Scientists at Weill Cornell Medical College have now solved this mystery by showing that metastatic incompetent cancers actually poison the "soil" by generating a microenvironment that blocks cancer cells from settling and growing in distant organs. Researchers also found that two key proteins involved in this process work by dramatically suppressing cancer's spread.

The study, reported in the April 30 issue of Cancer Discovery, offers hope that a drug based on these potentially therapeutic two proteins, Thrombospondin 1 (Tsp-1)- the poison produced by the microenvironment under the influence of tumor secreted protein prosaposin, might help keep human cancer at bay and from metastasizing.

"The majority of cancer-related deaths are due to metastasis, yet there are no approved targeted drugs that have shown significant benefit specifically in treating that spread. We may now finally have a lead on a strategy that could offer us that option for developing and guiding specific anti-metastatic therapeutic strategies in the clinic," says the study's senior investigator, Dr. Vivek Mittal, an associate professor of cell and developmental biology in cardiothoracic surgery and director of the Neuberger Berman Foundation Lung Cancer Laboratory at Weill Cornell Medical College.

"We have work to do on exploiting these novel insights into fruitful clinical translation, but our findings are, so far, very exciting," says Dr. Mittal.

Researchers from Children's Hospital in Boston, Harvard
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Decoded: Molecular messages that tell prostate and breast cancers to spread
2. UK study shows potential new way to detect colorectal and other cancers
3. Non-Melanoma Skin Cancers Tied to Risk for Other Cancers
4. New radiotherapy approach reduces symptoms of dry mouth in patients with head and neck cancers
5. Screening breast ultrasound detects cancers missed on mammography in women with dense breasts
6. LSUHSC research reveals Rx target for HPV, Hep C and related cancers
7. Fox Chase researchers find some lung cancers linked to common virus
8. UCLA researchers find potential link between auto pollution, some childhood cancers
9. Targeted toxin active in platinum-resistant ovarian cancers
10. Wake-Up Cigarette May Raise Risk for Lung, Mouth Cancers
11. Immortality gene mutation identifies brain tumors and other cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... a researcher from the Cancer Science Institute of Singapore ... identified the cancer specific stem cell which causes gastric ... new drugs for the treatment of this disease and ... by Dr Chan Shing Leng, Research Assistant Professor at ... cancer-specific variant of a cell surface protein, CD44v8-10, marks ...
(Date:4/23/2014)... Physical Activity on Mobility Limitation in Old Age , ... of mobility limitation in old age, whereas leisure-time physical ... study which followed up 5,200 public sector employees for ... Research Center in Finland and the Finnish Institute of ... wears the body and lasts for several hours a ...
(Date:4/23/2014)... may prevent the depletion of self-control, according to research ... the Association for Psychological Science. , Self-control can be ... focus attention on a boring textbook are hard things ... this difficulty: Exerting self-control for a long period seems ... subsequent tasks. , "It is as if self-control is ...
(Date:4/23/2014)... Getting to the bottom of Alzheimer,s disease has ... turns and controversies. In the latest crook in ... insight into the interaction between proteins associated with ... journal ACS Chemical Neuroscience , could have ... K. Surewicz, Krzysztof Nieznanski and colleagues explain that ...
(Date:4/22/2014)... visited the New Jersey Institute of Technology (NJIT) ... for the launch of the New Jersey Innovation ... new model for business innovation through the leveraging ... investment. U.S. Senator Cory Booker, Panasonic Corp. of ... Jersey Lieutenant Governor Kim Guadagno, New Jersey Secretary ...
Breaking Medicine News(10 mins):Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3Health News:Midlife occupational and leisure-time physical activity limits mobility in old age 2Health News:ADHD drug may help preserve our self-control resources 2Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2
... Instead of dismissing grumblings about being tired or exhausted, ... to a worsened health state or even death, says ... ,Dr. Karin Olson, a U of A professor from ... between tiredness, fatigue and exhaustion and that recognizing those ...
... study has found that a brief session of muscle-building exercise ... response.// ,The immune system’s reaction differs markedly between ... process remains unclear. ,“We’re trying to find ... benefit your vaccine response,” said lead author Kate Edwards, Ph.D., ...
... in the United States over age 20 are affected ... from the Johns Hopkins Bloomberg School of Public Health. ... age, cardiovascular disease, diabetes and a lack of physical ... lifestyle changes, such as increased physical activity and measures ...
... is a condition resulting from inflammation of joints. ... movement.// ,Spondylarthritis (SpA), ankylosing spondylitis (AS), ... all associated rheumatic diseases collectively known as "spondyloarthropathies".,Aside ... by ankylosis, stiffness and fusion of bone in ...
... which the bone mass in the body becomes reduced// and ... normally affects postmenopausal women. ,A McMaster University researcher ... a woman's problem but that the bone-wasting disease can severely ... professor of clinical medicine, and a group of five Canadian ...
... brain cell came from remain distinct even after the cell ... will report in the February 1 issue of Cancer Research. ... complexity to the quest to understand the causes of childhood ... Ph.D., the Donald O. Schnuck Family Professor of Neurology at ...
Cached Medicine News:Health News:Take Fatigue Seriously - Says Researcher 2Health News:Take Fatigue Seriously - Says Researcher 3Health News:Muscle-Building Exercise Improves Response to Flu Shot 2Health News:More Than 18 Million US Men Affected by ED 2Health News:Does Anti-TNF Therapy Control Ankylosis ? 2Health News:Osteoporosis Does Not Spare Men Either 2Health News:Genetic Fingerprints Identify Brain Tumors' Origins 2
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... India Drug Forecast and Market Analysis to ... PharmaPoint: Atopic Dermatitis - India Drug ...
(Date:1/15/2014)... , Jan. 15, 2014 ... research report is available in its ... Markets and Technologies for Advanced Drug ... of Administration ...
(Date:1/14/2014)... HeartWare International, Inc . (NASDAQ: HTWR ... support technologies that are revolutionizing the treatment of advanced ... the fourth quarter of 2013 will be approximately $53 ... million. "Our full-year revenue growth of 87% ...
Breaking Medicine Technology:PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4
... Calif., Oct 21 MAP Pharmaceuticals, Inc. (Nasdaq: ... of Thomas P. McCracken as Vice President, Intellectual ... property program in support of the potential commercialization ... inhaled migraine therapy, and other product opportunities. ...
... (San Francisco, CA and Ottawa, Ontario), a clinical-stage cancer ... Backer, Ph.D., to the newly-created position of senior vice ... all aspects of chemistry, manufacturing and controls (CMC) in ... pipeline products. "We are extremely pleased to ...
Cached Medicine Technology:MAP Pharmaceuticals Appoints Thomas P. McCracken as Vice President, Intellectual Property 2MAP Pharmaceuticals Appoints Thomas P. McCracken as Vice President, Intellectual Property 3Jennerex Names Dr. Mark P. Backer as Senior Vice President of Technical Operations 2
... Vibratome Semi-Automatic Tissue Sectioning System has maintained ... sectioning system. Researchers from around the globe ... for their fresh and fresh fixed tissue ... With the Vibratome Automatic Tissue Sectioning ...
... 1500 Sectioning System provides a versatile means ... plant tissues. The 1500 employs a ... freezing or embedding. The creation of ... of enzyme activities, and other deleterious effect ...
... Semi-Automatic Tissue Sectioning System has maintained the ... system. Researchers from around the globe have ... their fresh and fresh fixed tissue sectioning ... With the Vibratome Automatic Tissue Sectioning Systems, ...
... The NEW Vibratome 3000 Plus Sectioning ... fresh or fixed, animal, or plant tissues. ... principle which allows sectioning without freezing or ... alteration of morphology, the destruction of enzyme ...
Medicine Products: