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How red wine may shield brain from stroke damage
Date:4/21/2010

or good. He has not tested resveratrol in clinical trials. And while resveratrol is found in red grapes, it's the alcohol in the wine that may be needed to concentrate the amounts of the beneficial compound. Dor also cautions that drinking alcohol carries risks along with potential benefits.

He also notes that even if further research affirms the benefits of red wine, no one yet knows how much would be optimal to protect the brain, or even what kind of red wine might be best, because not all types contain the same amount of resveratrol. More research is needed, he says.

Dor says his research suggests that the amount needed could end up being quite small because the suspected beneficial mechanism is indirect. "Resveratrol itself may not be shielding brain cells from free radical damage directly, but instead, resveratrol, and its metabolites, may be prompting the cells to defend themselves," he suggests.

"It's not likely that brain cells can have high enough local levels of resveratrol to be protective," he says. The resveratrol is needed to jump-start this protective enzymatic system that is already present within the cells. "Even a small amount may be sufficient," Dor says.

Dor says his ongoing research also suggests some therapeutic benefits to giving resveratrol to mice after a stroke to limit further neuronal damage.


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Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

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