Navigation Links
How red blood cells get so big -- and the bad things that happen when they don't
Date:3/1/2012

Yale researchers have discovered how megakaryocytes giant blood cells that produce wound-healing platelets manage to grow 10 to 15 times larger than other blood cells.

The findings, to be published March 13 in the journal Developmental Cell, also hint at how a malfunction in this process may cause a form of leukemia.

"A failure of these cells to grow might be an initial trigger for megakaryoblastic leukemias," said Diane Krause, senior author of the paper, who is a researcher for the Yale Cancer Center; professor of laboratory medicine, cell biology, and pathology; and associate director of the Yale Stem Cell Center.

Megakaryocytes grow so large because the DNA within the cell duplicates many times but without the cell undergoing cell division: a process called endomitosis. A megakaryoblastic can shelter more than 120 sets of nuclear DNA before it eventually becomes the biological equivalent of a supernova, undergoing profound changes to break apart into thousands of platelets needed for normal blood clotting.

The Yale team led by postdoctoral associate Yuan Gao found that two proteins called guanine exchange factors (GEF-H1) put the brakes on endomitosis. They found that without GEF-H1, nuclear DNA couldn't go from two internal nuclei to four. Additional divisions of nuclear DNA within the cell could not take place unless there was decreased expression of a second factor, ECT2.

The researchers were intrigued by the results because a gene implicated in malignant leukemias, MKL1, also seems to be necessary to promote normal megakaryocyte maturation. The Krause lab is now studying whether mutant forms of MKL1 may keep levels of GEF-H1 high, thereby making it impossible for megakaryocytes to undergo endomitosis and setting the stage for development of cancer.

"These findings reveal another important step toward the formation of functional platelets, which are necessary for normal blood clotting," Krause said. "But they also provide a clue regarding what may go awry to transform normal megakaryocytes into malignant leukemia cells."


'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. Bowel disease link to blood clots
3. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
6. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
7. Bilberry Seems to Act Against Blood Sugar
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
10. NHLBI, CDC launch surveillance and research program for inherited blood diseases
11. IOM report declares high blood pressure a neglected disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... 2017 , ... Leading CEOs from biotech, pharmaceutical, and healthcare ... at The Four Seasons Hotel Boston. , The Boston CEO Conference is ... access to key decision makers who influence deal making and investment. Attendees gain ...
(Date:5/26/2017)... Plano, Texas (PRWEB) , ... May 26, 2017 , ... ... Cord Stimulation System, a powerfully versatile, patient-centric spinal cord stimulation system. The Nuvectra™ Algovita ... , “We are pleased to be the first in Arkansas to introduce the ...
(Date:5/26/2017)... ... May 26, 2017 , ... A new analysis of ... the healthiest seniors are located in the Midwest. With the average cost of healthcare ... people are concerned with both the quality and affordability of where they live. An ...
(Date:5/26/2017)... Nevada (PRWEB) , ... May 26, 2017 , ... ... produce the first ever copper, antimicrobial, mesh back 24/7 task chair specifically designed ... conference applications. “We are thrilled to partner with Cupron® to provide customers ...
(Date:5/26/2017)... ... ... After raising nearly $30,000 on Kickstarter , about three-times its original ... discounted crowdfunding price on Indiegogo . , “Along with creating an anti-stress gadget ... a fidget toy to the market that was made of superior quality and wouldn’t ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... 2017  Endo International plc (NASDAQ: ENDP ) ... will represent the Company in a fireside chat at Goldman ... June 13, 2017 at 10:40 a.m. PT / 1:40 p.m. ... Rancho Palos Verdes, CA. ... be available on the Company,s website at http://www.endo.com/investors/overview . ...
(Date:5/23/2017)... PLEASANTON, Calif. , May 23, 2017 /PRNewswire/ ... world,s most innovative medical devices for pressure ulcer ... at the American Association of Critical Care Nurses, ... Houston May 22-25. The Leaf Patient ... designed specifically for the hospital environment.  The system ...
(Date:5/18/2017)... , May 18, 2017  Two Bayer U.S. Pharmaceutical ... (HBA) during its recent 28 th Woman ... The event showcases HBA,s longstanding mission of furthering the ... healthcare. Cindy Powell-Steffen , senior director ... Radiology division, and Libby Howe , a regional ...
Breaking Medicine Technology: