Navigation Links
How our vision dims: Chemists crack the code of cataract creation
Date:12/5/2013

Irvine, Calif., Dec. 5, 2013 Groundbreaking new findings by UC Irvine and German chemists about how cataracts form could be used to help prevent the world's leading cause of blindness, which currently affects nearly 20 million people worldwide.

"That's the dream, and this is a big step," said Rachel Martin, UC Irvine associate professor of chemistry and co-author of a paper featured on the December cover of the journal Structure. "Understanding the molecular mechanism of what goes wrong in the eye that leads to a cataract could lead to the development of better treatment options, including more sophisticated artificial lenses and drugs."

It has long been known that human eyes have a powerful ability to focus because of three kinds of crystallin proteins in their lenses, maintaining transparency via a delicate balance of both repelling and attracting light. Two types of crystallin are structural, but the third dubbed a "chaperone" keeps the others from clumping into cataracts if they're modified by genetic mutation, ultraviolet light or chemical damage.

The UC Irvine team painstakingly explored and identified the structures of the normal proteins and a genetic mutation known to cause cataracts in young children. They found that the chaperone proteins bind far more strongly to the mutated proteins in an effort to keep the lens clear. One major problem: Every human eye contains a finite number of the helpful proteins. Once they're used up, the researchers learned, weakened ones quickly begin to aggregate and form blinding cataracts.

Now that this mechanism has been mapped at the molecular level, the team is hopeful that organic chemists can create sight-saving treatments to prevent such aggregation.

While people with adequate medical care can have corrective surgery for cataracts, the World Health Organization has found that millions suffer major vision loss because they do not have access to lase
'/>"/>

Contact: Janet Wilson
janethw@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Generation Next Film/Television, Journalism and Social Media Competition Deadline Extended to December 13, 2013
2. PowerSteering Recognized as a “Visionary” for Third Straight Year in Gartner’s Magic Quadrant for Integrated IT Portfolio Analysis Applications
3. Bilateral Biomet Hip Implants Cause Maryland Man Severe Pain, Elevated Metal Ion Levels, and Revision Surgeries, Alleges Lawsuit Filed by Parker Waichman LLP
4. Katie Johnson and Others Spoke About the Role of Children's Vision in Learning and Development at the 37th Annual WAEYC Fall Conference in Seatac, Washington in November
5. Horizon Healthcare, Inc. of Wisconsin Undertakes Bond Offering for its American Telehealthcare Division
6. Sam Rizk, MD, FACS, Top Revision Rhinoplasty Surgeon in Manhattan
7. Garden City Optometrist Dr. Steven Schoenbart Celebrates 25 Years in the Public Eye and the Treatment of Low Vision Patients
8. Global Vision Enters the Russian Market
9. NewsWatch Recently Featured the “Air Ace” Mobile Game Application on National Television
10. NewsWatch Airing on National Television, Thursday, November 21st
11. For many older adults, vision prescription differs between eyes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... (PRWEB) September 01, 2014 Registration is now ... Warriors® 5K and 1-Mile Race to be held on Sunday, ... Plaza Court Yard at Harmon Meadow in Secaucus, New Jersey. ... Warriors®, a national nonprofit dedicated to restoring a sense of ... service members and our military families. , General registration is ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 AttorneyOne.com, a ... all the latest information from the FDA on ... US FDA announced on August 28, that specific lots ... (Class I) as the device may reverse directions ... Synthes Craniomaxillofacial (CMF) Distraction System is an implant used ...
(Date:9/1/2014)... US (PRWEB) September 01, 2014 ... view into Heartbeat Experts’ perspectives on ... market. , Download the flash report to ... for any launching Diabetes product:, ... within an increasingly crowded market , ...
(Date:8/31/2014)... Just in time for Washington’s Indian Summer, ... Alaska Salmon, award winning chowder and legendary sourdough ... Lake location , Sunday, September 28, 2014 from 1 pm ... salmon BBQ culinary delights. Live music will add to the ... Rico and Mexico will be featured. “There is no ...
(Date:8/31/2014)... to celebrate the coming of autumn, Guangdong FODAY Automobile ... big promotion. Now, all the global clients can access cheap, ... are made with great materials. FODAY Automobile strives to offer ... of fact, it is providing big discounts on many of ... cheap cars can visit its website for more details. ...
Breaking Medicine News(10 mins):Health News:Hope For The Warriors New Jersey Run to Honor Wounded and Families of the Fallen 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 2Health News:DePuy Synthes Craniomaxillofacial Distraction System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 3Health News:Download HeartBeat Experts White Paper: Stakeholder Management for new Diabetes Products 2Health News:Seattle Seafood Restaurant Duke's Chowder House on Green Lake Will Celebrate The Long Anticipated Indian Summer With First Annual Sizzling BBQ Salmon Tasting Event. 2
... SMITHFIELD, R.I., July 29 FGX International,(Nasdaq: FGXI ... sunglasses and costume jewelry, today announced financial results,for its ... (Logo: http://www.newscom.com/cgi-bin/prnh/20071025/NETH104LOGO ), ... sales increased 14% to $71.6 million in the current ...
... WHITE PLAINS, N.Y., July 29 Four leaders,from the ... been elected to the national Board of Trustees of ... March of Dimes trustees, who serve as volunteers, represent ... and serve five-year,terms., The new trustees are:, ...
... cancer screening program in Norway and an approach to ... are equally sensitive for detecting cancer, researchers report in ... of the National Cancer Institute . But the recall ... Breast cancer screening in the United States is usually ...
... Income Per Share, SAN JOSE, Calif., July 29 ... leading provider of medical devices,for the minimally invasive treatment ... second quarter ended June 30, 2008., Net revenues ... $31.9,million compared with $17.2 million for the second quarter ...
... (Pink,Sheets: VSMD) announced today that Craig M. Walker, M.D., ... the number of directors from,four to five. Dr. Walker ... cardiologist, clinical investigator and thought leader., "Dr. Walker ... one of the,world,s leading experts in the care of ...
... literacy and,curbing HIV/AIDS is the centerpiece of the U.S. ... stabilize parts of,Haiti plagued by community unrest., The ... -- will,target public and private primary schools as well ... who manages a worldwide education and,health program for USAID., ...
Cached Medicine News:Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 2Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 3Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 4Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 5Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 6Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 7Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 8Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 9Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 10Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 11Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 12Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 13Health News:FGX International Reports Strong Sales and Earnings Growth for the Second Quarter and First Six Months of 2008 14Health News:Four Named to March of Dimes Board of Trustees 2Health News:Four Named to March of Dimes Board of Trustees 3Health News:Four Named to March of Dimes Board of Trustees 4Health News:Four Named to March of Dimes Board of Trustees 5Health News:Four Named to March of Dimes Board of Trustees 6Health News:Four Named to March of Dimes Board of Trustees 7Health News:2 different breast cancer screening strategies are equally effective 2Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 2Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 3Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 4Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 5Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 6Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 7Health News:VNUS Medical Technologies Reports Second-Quarter 2008 Results: 25% Growth in Net Product Revenues and 38% Growth in Unit Sales 8Health News:VASAMED(R) Appoints Craig M. Walker, MD to Board of Directors 2Health News:Three Rs and HIV/AIDS Mark New Haiti Literacy Plan 2
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "China Orthopedic Instrument Industry Report, 2014-2017" report ... aging population and rising proportion of reimbursement for medical ... effectively released, with its scale presenting a CAGR of ... products are three product segments of orthopedic instruments in ...
(Date:8/29/2014)... DUBLIN , Aug. 29, 2014 ... the "Research and Development Trend Forecast of Pharmaceutical ... offering. Research and Development Trend Forecast ... , 2014-2018 mainly analyzes China,s ... status, supply & demand, competition landscape, and business performance ...
(Date:8/29/2014)... -- Unilife Corporation ("Unilife" or "Company") (NASDAQ: UNIS ... release its financial results for the fiscal 2014 fourth ... trading ends on Tuesday, September 9, 2014. ... p.m. U.S. EDT on Tuesday, September 9, 2014 (Wednesday, ... Company,s financial results, commercial partnerships, and future outlook.  The ...
Breaking Medicine Technology:China Orthopedic Instrument Industry Report, 2014-2017 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2
... Md., April 11, 2012 Sunpeaks Ventures, Inc. (OTCBB: ... its wholly owned subsidiary Healthcare Distribution Specialists, LLC ("HDS") ... an agreement with DS Healthcare Limited to assist in ... Under terms of the agreement, DS Healthcare will evaluate ...
... has used an electronic clinical system since its inception in ... original technology with an enterprise clinical and financial solution from ... start out as a completely electronic hospital. But we realize ... all of our needs," says Jeremy Lyman, CFO at the ...
Cached Medicine Technology:Sunpeaks Ventures Enters Agreement with UK Based Healthcare Firm to Introduce Clotamin to UK and European Union Countries 2Blue Mountain Hospital Selects Enterprise System from Prognosis HIS 2Blue Mountain Hospital Selects Enterprise System from Prognosis HIS 3
The Vitatron Slimtine S lead series are endocardial leads with an excellent history of reliability and optimal handling en pacing performance....
Bipolar Atrial "J" Lead...
Unipolar temporary atrial pacing lead is smaller and thinner than Medtronics standard temporary pacing leads. It is well suited for thin, delicate, atrial tissue....
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
Medicine Products: