Navigation Links
How our vision dims: Chemists crack the code of cataract creation
Date:12/5/2013

Irvine, Calif., Dec. 5, 2013 Groundbreaking new findings by UC Irvine and German chemists about how cataracts form could be used to help prevent the world's leading cause of blindness, which currently affects nearly 20 million people worldwide.

"That's the dream, and this is a big step," said Rachel Martin, UC Irvine associate professor of chemistry and co-author of a paper featured on the December cover of the journal Structure. "Understanding the molecular mechanism of what goes wrong in the eye that leads to a cataract could lead to the development of better treatment options, including more sophisticated artificial lenses and drugs."

It has long been known that human eyes have a powerful ability to focus because of three kinds of crystallin proteins in their lenses, maintaining transparency via a delicate balance of both repelling and attracting light. Two types of crystallin are structural, but the third dubbed a "chaperone" keeps the others from clumping into cataracts if they're modified by genetic mutation, ultraviolet light or chemical damage.

The UC Irvine team painstakingly explored and identified the structures of the normal proteins and a genetic mutation known to cause cataracts in young children. They found that the chaperone proteins bind far more strongly to the mutated proteins in an effort to keep the lens clear. One major problem: Every human eye contains a finite number of the helpful proteins. Once they're used up, the researchers learned, weakened ones quickly begin to aggregate and form blinding cataracts.

Now that this mechanism has been mapped at the molecular level, the team is hopeful that organic chemists can create sight-saving treatments to prevent such aggregation.

While people with adequate medical care can have corrective surgery for cataracts, the World Health Organization has found that millions suffer major vision loss because they do not have access to laser surgery or other options. By 2019, the number of people older than 50 with impaired sight is expected to grow even higher, particularly in China, India, Southeast Asia and Eastern Mediterranean nations.


'/>"/>

Contact: Janet Wilson
janethw@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Generation Next Film/Television, Journalism and Social Media Competition Deadline Extended to December 13, 2013
2. PowerSteering Recognized as a “Visionary” for Third Straight Year in Gartner’s Magic Quadrant for Integrated IT Portfolio Analysis Applications
3. Bilateral Biomet Hip Implants Cause Maryland Man Severe Pain, Elevated Metal Ion Levels, and Revision Surgeries, Alleges Lawsuit Filed by Parker Waichman LLP
4. Katie Johnson and Others Spoke About the Role of Children's Vision in Learning and Development at the 37th Annual WAEYC Fall Conference in Seatac, Washington in November
5. Horizon Healthcare, Inc. of Wisconsin Undertakes Bond Offering for its American Telehealthcare Division
6. Sam Rizk, MD, FACS, Top Revision Rhinoplasty Surgeon in Manhattan
7. Garden City Optometrist Dr. Steven Schoenbart Celebrates 25 Years in the Public Eye and the Treatment of Low Vision Patients
8. Global Vision Enters the Russian Market
9. NewsWatch Recently Featured the “Air Ace” Mobile Game Application on National Television
10. NewsWatch Airing on National Television, Thursday, November 21st
11. For many older adults, vision prescription differs between eyes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  Caris Life Sciences ® , a leading ... of precision medicine, today announced that St. Jude Medical ... Alliance™ (POA) as its 17 th member. Through ... Crosson Cancer Institute will help develop standards of care ... profiling, making cancer treatment more precise and effective. ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, ... more than $100 billion in purchasing power, today announced ... and information. The Newsroom is the online ... industry trends, infographics, expert bios, news releases, slideshows and ... access to a wealth of resources at their fingertips, ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
Breaking Medicine Technology: