Navigation Links
How mom's health may increase risk of kidney disease

Children with Chronic Kidney Disease (CKD) are more likely to have mothers who were obese or had diabetes during pregnancy, according to a study presented at the American Society of Nephrology's 43rd Annual Meeting and Scientific Exposition, by Christine W. Hsu, MD (University of Washington, Seattle) and colleagues.

The study included more than 4,000 patients with childhood CKDdiagnosed at age 21 or youngerin Washington State. These patients were compared to more than 20,000 healthy children to evaluate possible relationships between a pregnant woman having diabetes, being obese or overweight, and the risk of her child developing CKD anytime during infancy, childhood, or adolescence.

The overall rate of childhood CKD was approximately 0.26 percentabout 1 case per 400 live births. When investigators adjusted for length of gestation, CKD risk was 69 percent higher for children whose mothers had diabetes before pregnancy. For children whose mothers developed diabetes during pregnancy (gestational diabetes), there was a 28 percent increase in CKD risk. Children of obese mothers demonstrated a 22 percent increase in CKD risk.

When specific causes of kidney disease were analyzed, children whose mothers had diabetes before pregnancy had nearly a 700 percent increase in the risk of kidney-related birth defects (renal aplasia/dysplasia). "Developmental abnormalities of the kidney and urinary tract are the most common cause of childhood CKD," Hsu explains.

The risk of urinary blockage (obstructive uropathy) which can lead to CKDwas increased by 34 percent for children whose mothers had gestational diabetes, 23 percent in those whose mothers were obese, and 21 percent in those whose mothers were overweight but not obese.

In adults, CKD is often related to medical conditions like diabetes and high blood pressure. In contrast, according to Hsu, "Development of childhood CKD may be programmed prenatally." Few studies have looked at possible risk factors for CKD development before adulthood.

"Our research shows that childhood CKD is modestly associated with maternal diabetes and maternal overweight or obesity, with the strongest association between abnormal kidney development and maternal diabetes," says Hsu. "Previous studies have demonstrated that maternal diabetes is associated with an increased risk of general congenital abnormalities. However, with strict control of maternal diabetes, the rate of congenital malformations is similar to that of non-diabetic mothers."

The new results raise the possibility that stricter control of diabetes and weight control during pregnancy could decrease children's risk of developing CKD. "However, this would have to be evaluated in future research," says Hsu.

The study had some limitations related to the fact that it used Washington State birth records linked to a hospital discharge database. As a result, it could only identify children with CKD who were hospitalized and had kidney disease listed in their hospital discharge diagnoses. The study definition of CKD was also broad, and the results are being reanalyzed with a stricter CKD definition. Furthermore, conclusions regarding cause and effect are not possible due to the case control design of the study.


Contact: Shari Leventhal
American Society of Nephrology

Related medicine news :

1. Jennifer Garner Tops Power Plate(R) Power Moms of 2009 List
2. Be Well Book Launches National Movement to Help Moms Instill Healthy Habits and End Childhood Obesity
3. Ft. Lauderdale Plastic Surgeon Robert E. Rothfield MD Restoring Curves and Self-Esteem in New Moms with Mommy Makeover
4. The Hispanic got milk? Campaign Visited Houston to See How Moms Saborean El Momento!
5. The Hispanic got milk? Campaign Visited Dallas to Ask How Moms Saborean el Momento!
6. Bloggermoms Releases 'Top 10 Things to do with Kids for Earth Day, Earth Week and Earth Month'
7. Severe Morning Sickness Passed From Moms to Daughters
8. Moms who dont breastfeed more likely to develop type 2 diabetes
9. Brain Anomalies Found in Moms With Postpartum Depression
10. Breast-Feeding Less Common for Black Moms
11. New Moms Brains May Grow After Childbirth
Post Your Comments:
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... NORTHBROOK, Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the ... joins Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... appointed General Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: