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How meningitis bacteria attack the brain
Date:8/18/2009

s from 7 to 23 of the most common strains of pneumococcus.

"Our immune system generates antibodies more readily against protein rather than sugar vaccine antigens," said Nizet. "Since at least 80 different pneumococcal capsule types exist, not all strains can be represented in the capsule sugar-based vaccines. An added benefit of an effective NanA vaccine would be to reduce the risk of pneumococcus spreading into the brain to cause meningitis."

Ongoing research in the Nizet and Doran labs will seek to characterize the receptor on the blood-brain barrier cells to which NanA binds, and to explore whether similar processes contribute to the ability of other meningitis pathogens such as group B streptococcus to pass through the blood-brain barrier.


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Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

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