Navigation Links
How immune cells destroy cancer cells - MDC researchers elucidate mechanism
Date:1/17/2012

, comparable to clinical-size tumors in patients. Only then, according to the researchers, is the development of the tumor tissue (tumor stroma), which also includes the tumor vasculature, complete. The tumor is then considered "established". The aim of tumor therapy is to kill all cancer cells to prevent the recurrence of cancer disease.

The researchers showed in mice that the tumor is destroyed by the drug-mediated inactivation of the oncogene, but that the tumor vasculature and thus the blood supply of the tumor remains intact. In addition, due to a high mutation rate, some cancer cells become resistant to the drug and quickly generate new tumors despite continual administration of the anti-cancer drug.

Adoptive T-cell therapy, the researchers noted, is more effective in the mice in the long term, because it destroys the blood supply of the tumor. In addition, it evidently intercepts cancer cells that have altered their characteristics via mutations and thus escape drug treatment. In adoptive T-cell therapy, the researchers modulate the cytotoxic T cells (immune cells toxic for the cell) in the test tube in such a way that the T cells recognize certain features on the surface of cancer cells and specifically destroy the tumor cells. Then these primed immune cells are transferred back into the mice. The researchers point out that techniques to produce highly specialized T cells against human tumors have recently been developed following previous studies by Professor Blankenstein's research group. Now it will be important to determine exactly how these immune cells can be used in future clinical trials.

*Oncogene-targeting T cells reject large tumors, while oncogene inactivation selects escape variants in mouse models of cancer


'/>"/>
Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A genetic accelerator hits the gas on autoimmune diseases
2. Gene Research Sheds Light on Rare Immune Disease
3. Self-regulation of the immune system suppresses defense against cancer
4. Severe Sepsis Can Harm the Immune System
5. Team pinpoints amino acid variation in immune response gene linked with ulcerative colitis
6. Researchers investigate link between autoimmune diseases and wounds that dont heal
7. Pep talk can revive immune cells exhausted by chronic viral infection
8. Penn researchers repair immune system in leukemia patients following chemotherapy
9. Traumatic injury sets off a genomic storm in immune system pathways
10. Autoimmune Woes May Raise Risk for Lung Clots
11. U-M Medical School and MedImmune join forces to accelerate search for new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 14, 2014 A new study found that ... stenting of true coronary bifurcation lesions yields similar ... DKCRUSH-VI clinical trial is the first study to ... were reported today at the 26th annual Transcatheter ... Cardiovascular Research Foundation (CRF), TCT is the world,s ...
(Date:9/16/2014)... 16, 2014 Programs and policies that ... of billions of dollars in savings for the US ... Commonwealth Fund. To help spur these types of improvements, ... 10 collaborative groups from across the country to field ... ) - a handbook designed to assist groups working ...
(Date:9/16/2014)... 2014 As part of its Latinos ... Citizens (LULAC) will host the second annual health festival ... feature free health screenings for osteoporosis, HIV, and high ... and cholesterol levels as well as bone marrow typing. ... under 6 years old , The event will also ...
(Date:9/16/2014)... Dennis Thompson HealthDay Reporter ... combination drug therapy aimed at opening the airways and ... older adults with chronic obstructive pulmonary disease (COPD), especially ... COPD patients who received a combination of long-acting beta ... or require hospitalization because of their breathing disorder, compared ...
(Date:9/16/2014)... NC (PRWEB) September 16, 2014 Danny ... on a Fall workshop tour with events throughout the ... the natural running movement and has taught a full ... is now offering ChiWalk-Run and ChiWalking tracks at his ... enjoy the benefits of the Chi techniques. , Workshop ...
Breaking Medicine News(10 mins):Health News:Results of DKCRUSH-VI trial reported at TCT 2014 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 3Health News:LULAC Hosts Second Annual Latinos Living Healthy Feria de Salud in Los Angeles 2Health News:Combo Therapy Best for COPD: Study 2Health News:Combo Therapy Best for COPD: Study 3Health News:Join ChiRunning® Founder, Danny Dreyer, on Fall 2014 US Workshop 2Health News:Join ChiRunning® Founder, Danny Dreyer, on Fall 2014 US Workshop 3
... tau helped in the reduction of Alzheimer’s symptoms in mice. ... treatment// to a deadly brain disorder, scientists hope. ... said, “If this strategy also works in humans, it could ... ,The researchers, whose work is published in the journal Science, ...
... Gastroenterology suggests that smoking may determine which part of ... from Crohn’s disease. Where the disease is located often ... ,“In patients who smoke, Crohn’s disease tends ... than the colon,” says study author Dr. Marian Aldhous. ...
... is seeking to raise glaucoma awareness among Mexican-Americans, who have ... Grande Valley Dispatch reports. ,Mexican-Americans over age ... history of glaucoma all face a higher risk for the ... most common form glaucoma. ,The rate increases ...
... American Cancer Society is launching a major new cancer research ... large-scale population research// in the United States to discover the ... ,The Cancer Prevention Study 3 (CPS-3) aims to enroll ... adults across the United States to help pave the way ...
... indicated that the culprit to most health threat is the ... and heating. According to the UN 5% of the preventable ... ,This study is based on a new estimate ... the physical, chemical, and biological characteristics of air in the ...
... women who like their meat smoked or barbequed. // ... consumed the most grilled, barbecued or smoked red meat over their ... meat-eaters who also skimped on fruit and vegetables had a 74 ... Susan E. Steck of the University of South Carolina in Columbia, ...
Cached Medicine News:Health News:American Cancer Society Launches Major New Study 2Health News:American Cancer Society Launches Major New Study 3Health News:Barbeque Lovers Warned To Load On Fruits And Vegetables 2
(Date:9/16/2014)... BETHESDA, Md. , Sept. 16, 2014 ... CHDX ) announced that, at a special meeting ... previously announced merger agreement (the "Merger  Agreement") by and ... Healthy Harmony Acquisition, Inc. ("Merger Sub"). Parent is an ... ("Fosun") and Ms. Roberta Lipson , the CEO ...
(Date:9/16/2014)... 16, 2014 Research and Markets has ... 2014-2018" report to their offering. Animal ... animals. Animal vaccines are generally prepared from weakened or dead ... healthy state. Some of the animal vaccines are also formulated ... subunits or toxic components. These components act ...
(Date:9/16/2014)... QPID Health , a leader in clinical ... Boston and their first West Coast ... 175 Franklin Street in Boston , and will ... new Southern California office will be ... help meet the demands of customers nationwide.  Both new locations ...
Breaking Medicine Technology:Chindex Stockholders Approve Merger 2Chindex Stockholders Approve Merger 3Global Animal Vaccines Market 2014-2018: Key Vendors are Bayer, Elanco, Merck, Novartis, Sanofi and Zoetis 2Global Animal Vaccines Market 2014-2018: Key Vendors are Bayer, Elanco, Merck, Novartis, Sanofi and Zoetis 3QPID Health Announces Major Office Expansion in Boston and Opens Facility in San Diego 2
... STAMFORD, Conn., Oct. 15 AmeriCares has awarded its ... of the largest health care products and services companies ... presented the award today at the Healthcare Distribution Management ... The Power of Partnership Award was created by AmeriCares ...
... , NEW YORK, Oct. 15 This year,s American ... is shaping up to be an unforgettable evening. With ... annual fundraising gala is being held on the historic Intrepid ... Over 600 people will be in attendance, including diplomats, civic, ...
Cached Medicine Technology:AmeriCares Honors Cardinal Health with Power of Partnership Award 2AmeriCares Honors Cardinal Health with Power of Partnership Award 3Larry King to Host 10th Annual American Friends of Rabin Medical Center 'Broadway on the Hudson' Gala 2Larry King to Host 10th Annual American Friends of Rabin Medical Center 'Broadway on the Hudson' Gala 3
... 265 is a highly accurate portable, waterproof system ... measurements. Temperature compensated pH results can be obtained ... a 3-in-1 electrode. • This GLP/GMP compliant system ... printer or a computer. Up to 100 data ...
... a highly accurate portable system for pH, mV ... pH results can be obtained when used with ... • This GLP/GMP compliant system includes an RS-232 ... computer. Up to 100 data sets can be ...
... Over-sized compressor. Triple pane thermal glass. ... System No plumbing required. Equipped with a ... on Parts & Labor and an Additional 4 ... as a chromatography unit which includes two access ...
... equipped, waterproof system for pH, mV (ORP), relative ... pH results can be obtained when used with ... Up to five custom buffers are supported. • ... to connect to a printer or a computer. ...
Medicine Products: