Navigation Links
How immune cells destroy cancer cells - MDC researchers elucidate mechanism
Date:1/17/2012

In the treatment of large tumors, how effective is adoptive T cell therapy in comparison to drug-based cancer treatment? To answer this question, Dr. Kathleen Anders and Professor Thomas Blankenstein of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and researchers of the Beckman Research Institute of the City of Hope Cancer Center in Duarte, California, USA designed and carried out a study comparing the two methods. Based on a mouse cancer model, the researchers elucidated the mechanisms of the two different treatments. The researchers showed that both forms of therapy are highly effective against large tumors. However, the T cells not only kill cancer cells they additionally destroy the tumor blood vessel system, thus impeding the supply of nutrients to the tumor. Consequently, quasi as a side effect, "escapee" mutant tumor cells are eradicated that have become resistant to drug-based treatment and are responsible for tumor recurrence. The researchers hope that their insights in defining optimal conditions for T cell therapy may help improve future clinical trials and thus the treatment of cancer patients (Cancer Cell, doi10.1016/j.ccr.2011.10.019)*.

The researchers transplanted tumor cells into mice that express SV40 large T antigen (Tag), the oncogene that is critical for tumor growth. The researchers were thus able to target and inactivate the oncogene using the antibiotic drug doxycycline (dox), which has an effect similar to modern drugs currently in clinical use. Since the oncogene is also present as antigen on the surface of the tumor cells, the researchers were also able to target these tumors with oncogene-specific T cells. Thus, for the first time the effect of the two completely different therapy approaches could be compared directly with each other.

Moreover, a special feature of the study was that the tumors in the mice were large bigger than one centimeter and containing about one billion cancer cells
'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A genetic accelerator hits the gas on autoimmune diseases
2. Gene Research Sheds Light on Rare Immune Disease
3. Self-regulation of the immune system suppresses defense against cancer
4. Severe Sepsis Can Harm the Immune System
5. Team pinpoints amino acid variation in immune response gene linked with ulcerative colitis
6. Researchers investigate link between autoimmune diseases and wounds that dont heal
7. Pep talk can revive immune cells exhausted by chronic viral infection
8. Penn researchers repair immune system in leukemia patients following chemotherapy
9. Traumatic injury sets off a genomic storm in immune system pathways
10. Autoimmune Woes May Raise Risk for Lung Clots
11. U-M Medical School and MedImmune join forces to accelerate search for new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... In a recent article published by the ... (UCL) study showed that dental experts from around the ... was the most effective. Analysis of 66 different advice ... frequently recommended, but none were favored by a majority. ... experienced cosmetic dentist Dr. Patrick J. Broome, DMD, ...
(Date:8/20/2014)... August 20, 2014 Hope For The ... Hope® Celebration to be hosted in Washington, DC on ... Club. This signature event honors the courage of our ... the fallen. Proceeds from the Got Heart, Give Hope® ... nonprofit dedicated to restoring a sense of self, restoring ...
(Date:8/20/2014)... WA (PRWEB) August 20, 2014 No matter ... always count on a steady set of friends to be ... when it comes to the concept of making new ... by various responsibilities ranging from taking care of one’s family ... comes with talking to a new person just is not ...
(Date:8/20/2014)... Ticketability.com has Theresa Caputo ... prices. The well-known medium has been thrilling many with ... in 19 cities, with tickets becoming available August 15. ... visit are Albany, Baltimore, Trenton, Erie, Buffalo, Philadelphia, Charlotte, ... and San Diego. The medium’s fans can obtain Theresa ...
(Date:8/20/2014)... Low market concentration, low price volatility, ... typify the market for packaging design services. These factors ... 5, indicating a moderate level of buyer power. “This ... an equal amount of leverage during negotiations,” according to ... substitutes exist for packaging design services . Buyers ...
Breaking Medicine News(10 mins):Health News:Ending Confusion About the Best Way to Brush Teeth 2Health News:Ending Confusion About the Best Way to Brush Teeth 3Health News:Hope For The Warriors Announces Got Heart, Give Hope Celebration in Washington, DC 2Health News:‘How to Make Friends as an Adult by Just Being Yourself: Becoming a “People Person” In Three Steps or Less’ Gives Tips for Making Friends During Adulthood - Vinamy 2Health News:Theresa Caputo Tour Tickets for Sale at Ticketability.com Cause a Buying Frenzy Among Customers Over Their Offering of Deeply Discounted Seats 2Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 2Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 3Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 4
... by SharpBrains CEO on June 11th, during Games for Health Conference ... How can you take care of your brain when every ... to contradict each other? Do supplements improve memory? Do you need ... enough? Which brain training approach, if any, is worth your time ...
... York Hospital Queens One of Clinical Sites, Research Director is Co-Author ... world,s most respected medical journals, the New England Journal of ... treatments for people with both Type 2 diabetes and coronary artery ... Queens was one of the sites that conducted this study. ...
... (June 9, 2009) Carl D. Stevens, MD, MPH, ... Harbor-UCLA Medical Center (LA BioMed), recently received the Award ... Geffen School of Medicine at the University of California, ... dedication, innovation and sustained excellence in education." ...
... ANN ARBOR, Mich.---In places where young women outnumber young men, ... because the young men feel less pressure to settle down ... when those men reach their 30s, the reverse is true ... women outnumber men. Daniel Kruger, a University of ...
... meet criteria for full alert, agency says , TUESDAY, June ... swine flu in Australia may tip the balance and cause ... pandemic since 1968, agency officials said Tuesday. , Cases in ... occurring in the southern state of Victoria. Rapid spread of ...
... to a restful night, study finds , TUESDAY, June 9 ... trouble getting a good night,s sleep, you may want to ... that they slept better after trying meditation, according to a ... annual meeting of the Associated Professional Sleep Societies, in Seattle. ...
Cached Medicine News:Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 2Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 3Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 4Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 5Health News:Landmark Study Published in New England Journal of Medicine 2Health News:Landmark Study Published in New England Journal of Medicine 3Health News:When young men are scarce, they're more likely to play the field than to propose 2Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 2Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 3Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 4Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 5Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 6Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 7Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 8Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 9Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 10Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 11Health News:Meditation May Help Put Primary Insomnia to Bed 2
(Date:8/19/2014)... 2014  Tokyo-based Atonarp Inc. announced today $8 ... by Walden Riverwood Ventures with participation from other ... Smart Spectrometer technology platform, which will enable a ... the oil & gas and healthcare industries for ... to partner with Atonarp in pursuing the commercialization ...
(Date:8/19/2014)... , Aug. 19, 2014 Avizia, Inc., a ... it has closed an equity financing round led by ... Capital. The new funding will be used to continue ... financing round, Avizia welcomes Edward Kennedy , CEO ... directors. He joins Leonard Kurtzman , CFO of ...
(Date:8/19/2014)... Aug. 19, 2014  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) ... , Sanofi and Regeneron will host an IR Thematic ... Tuesday, September 2, 2014 , Baird 2014 Healthcare ... 3, 2014 , Citi,s 9 th Annual ... September 4, 2014 , Morgan Stanley Global Healthcare ...
Breaking Medicine Technology:Atonarp Inc. Raises $8M Series A Round Led by Walden Riverwood Ventures 2Avizia Closes Funding Round 2
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
Steroid-eluting, screw-in pacing lead...
Medicine Products: