Navigation Links
How embryonic stem cells develop into tissue-specific cells demonstrated
Date:5/12/2008

Jerusalem, May 12, 2008 While it has long been known that embryonic stem cells have the ability to develop into any kind of tissue-specific cells, the exact mechanism as to how this occurs has heretofore not been demonstrated. Now, researchers at the Hebrew University of Jerusalem and elsewhere have succeeded in graphically revealing this process, resolving a long-standing question as to whether the stem cells achieve their development through selective activation or selective repression of genes.

The collaborative research group, which included Dr. Eran Meshorer of the Department of Genetics at the Silberman Institute of Life Sciences at the Hebrew University of Jerusalem, has revealed that the embryonic stem (ES) cells express large proportions of their genome promiscuously. This permissive expression includes lineage-specific and tissue-specific genes, non-coding regions of the genome that are normally silent, and repetitive sequences in the genome, which comprise the majority of the mammalian genome but are also normally not expressed.

When ES cells differentiate into specific cell tissue-types, they undergo global genetic silencing. But until this occurs, the ES cells maintain an open and active genome. This might very well be the secret of their success, since by maintaining this flexibility they maintain their capacity to become any cell type. Once silencing, or genetic repression, occurs, this ability is gone.

Thus, one can say that the ES cells stand at the ready until the last minute -- prepared to engage in selective activation into specific cells -- holding in abeyance their ability to become any kind of cells at the point and time required.

To reveal the process as to how this occurs, the researchers created the first full-mouse genomic platform of DNA microarrays. Microarrays are glass-based chips that allow simultaneous detection of thousands of genes. The microarrays used in the study were not confined to specific genes only but spanned the entire genome.

Hundreds of such microarrays were required in the study to cover the entire genome in different time points during stem cell differentiation. It was by observation of these sequences that the researchers were able to establish exactly how and at what point the stem cells developed into specific tissue cells and when the silencing occurs.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert

Related medicine news :

1. March of Dimes awards $250,000 prize to leaders in understanding embryonic development
2. Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
3. Embryonic Stem Cells Turned Into Three Types of Heart Cells
4. Embryonic stem cells could help to overcome immune rejection problems
5. Module map links embryonic stem cells and cancer stem cells
6. UCLA researchers examine human embryonic stem cell genome
7. Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
8. Molecular alliance that sustains embryonic stem cell state
9. Embryonic Stem Cell Protein Inhibits Melanoma
10. Protein in embryonic stem cells control malignant tumor cells
11. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Wash Tower Ltd. has ... launch of the Wash Tower, the world's first standalone constant pressure bidet. , The ... the company's website at https://www.washtower.com as well as on its social media ...
(Date:3/22/2017)... ... March 22, 2017 , ... Drs. Jennifer Houck, Lauren Smith, ... to accept new patients in need of skilled pediatric dentistry in Rock ... Care offers pediatric patients routine treatments, including cavities, sealants and fluoride applications, in a ...
(Date:3/22/2017)... TX (PRWEB) , ... March 22, 2017 , ... ... medical imaging core lab with extensive therapeutic experience and operational excellence in oncology ... II immuno-oncology clinical trial for the treatment of non-small cell lung cancer and ...
(Date:3/22/2017)... ... 22, 2017 , ... The Tyler Hitchcock Agency, a Dallas ... eastern Texas, is announcing a charity drive in conjunction with the North Texas ... , Consistently a top-rated nonprofit organization for hunger relief, the North Texas ...
(Date:3/22/2017)... ... March 22, 2017 , ... Chris Humphrey Insurance Agency, a North Carolina ... throughout the coastal plains region, is initiating a charity event to raise support for ... first diagnosed with leukemia on a Friday evening in September 2014. At the time, ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017 A new ... Disinfectorâ„¢ is the proven ultraviolet-C (UV-C) disinfection solution ... infections (HAIs). Published in the ... Infection Control , the peer-reviewed study of UV-C ... of Vancouver General Hospital and Rochester General Hospital. ...
(Date:3/22/2017)... FinancialBuzz.com News Commentary  ... According to a report by the New Frontier Data, the ... and is projected to grow at a compound annual growth rate ... The medical cannabis market is projected to grow at 12% CAGR ... estimated $13.3 billion in 2025. These projections do not include assumptions ...
(Date:3/22/2017)... , March 22, 2017 TFS is ... and Mr. Ed Tumaian , two global executive positions in ... be joining the Operational Leadership Team and will report to Dr. ... ... comes to TFS with 10 years of medical and scientific expertise ...
Breaking Medicine Technology: