Navigation Links
How does sodium phosphate combined with bisacodyl affect small intestine?
Date:5/20/2008

Capsule endoscopy is a well accepted tool for evaluation of small bowel pathologies (e.g., bleeding sources). However, it has some limitations due to restricted recording time and reduced visibility by air and residual material. Several forms of preparation (e.g., prokinetic drugs, laxatives and defoaming agents) have been tried to improve the quality of the examination. However, to date no standardized protocol has been recommended for bowel preparation for CE.

This study, described in a research article, is to be published on April 7, 2008 in the World Journal of Gastroenterology.

We examined the effect of a combination of a saline (sodium phosphate) and a stimulant laxative (bisacodyl, Prepacol(R), Guerbet GmbH, Sulzbach, Germany) as a preparation before CE. Sodium phosphate solution is poorly absorbable and impedes water absorption from the gut through the osmotic gradient. Bisacodyl changes the net absorption of sodium and water in the small bowel into a net secretion and accelerates small intestinal transit.

52 consecutive patients receiving capsule endoscopy were included. The patients were prospectively randomized into two groups. Group A fasted at least 8 h before the examination; group B received additional Prepacol(R). Capsule endoscopy films were evaluated by three independent, endoscopically experienced investigators who were blinded concerning the kind of preparation. The following parameters were assessed: total quality of the film, visibility of small bowel mucosa, velocity of the capsule and occurrence of foam, air and residual food. Every parameter was graded from 1 to 4, as excellent, good, limited and poor quality.

Preparation with Prepacol(R) accelerated small bowel transit time , but had no effect on the different parameters of CE quality.

In the view of the authors, the investigated combination of sodium phosphate and bisacodyl is an inappropriate preparation for CE. Because CE is an expensive and time consuming examination, an effective preparation is essential to minimize false results at the best possible rate. Further studies considering the patient's compliance, which might be reduced by the taste of the preparation, are necessary to identify sufficient preparation procedures.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. District Court Decision Affirmed in U.S. Lovenox(R) (enoxaparin sodium) Patent Infringement Case
2. Frito-Lay Launches Low Sodium Versions of its Top Selling Snack Chips
3. Sodium Content Foods and Beverages Gain Revenues as Americans are Embracing Low- and No-Sodium Campaigns
4. Roxane Laboratories, Inc. Announces the Launch of Balsalazide Disodium Capsules, 750mg
5. AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium
6. Data Show Vaprisol(R) Is Effective & Safe in Promptly Increasing Serum Sodium Levels in Patients With Euvolemic or Hypervolemic Hyponatremia
7. Diffusion Pharmaceuticals Announces Results of Phase I Human Trial of Lead Drug Candidate, Trans Sodium Crocetinate (TSC) and Completion of a $4.5 Million Private Placement
8. Cutting Phosphate May Protect Kidney Patients From Heart Trouble
9. FDA Advisory Committee Votes in Favor of Earlier Use of Phosphate Binders in Stage 4 Kidney Disease Patients With Hyperphosphatemia
10. Genzyme Statement Regarding Results of FDA Advisory Committee Meeting on the Use of Phosphate Binders in Chronic Kidney Disease
11. Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- Story Highlights: , ... health care industry is causing providers to review operating ... offers a suite of solutions for health care providers ... optimization: labor resource analysis, revenue cycle optimization and physician ... and better economics ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
Breaking Medicine Technology: