Navigation Links
How does sodium phosphate combined with bisacodyl affect small intestine?
Date:5/20/2008

Capsule endoscopy is a well accepted tool for evaluation of small bowel pathologies (e.g., bleeding sources). However, it has some limitations due to restricted recording time and reduced visibility by air and residual material. Several forms of preparation (e.g., prokinetic drugs, laxatives and defoaming agents) have been tried to improve the quality of the examination. However, to date no standardized protocol has been recommended for bowel preparation for CE.

This study, described in a research article, is to be published on April 7, 2008 in the World Journal of Gastroenterology.

We examined the effect of a combination of a saline (sodium phosphate) and a stimulant laxative (bisacodyl, Prepacol(R), Guerbet GmbH, Sulzbach, Germany) as a preparation before CE. Sodium phosphate solution is poorly absorbable and impedes water absorption from the gut through the osmotic gradient. Bisacodyl changes the net absorption of sodium and water in the small bowel into a net secretion and accelerates small intestinal transit.

52 consecutive patients receiving capsule endoscopy were included. The patients were prospectively randomized into two groups. Group A fasted at least 8 h before the examination; group B received additional Prepacol(R). Capsule endoscopy films were evaluated by three independent, endoscopically experienced investigators who were blinded concerning the kind of preparation. The following parameters were assessed: total quality of the film, visibility of small bowel mucosa, velocity of the capsule and occurrence of foam, air and residual food. Every parameter was graded from 1 to 4, as excellent, good, limited and poor quality.

Preparation with Prepacol(R) accelerated small bowel transit time , but had no effect on the different parameters of CE quality.

In the view of the authors, the investigated combination of sodium phosphate and bisacodyl is an inappropriate preparation for CE. Because CE is an expensive and time consuming examination, an effective preparation is essential to minimize false results at the best possible rate. Further studies considering the patient's compliance, which might be reduced by the taste of the preparation, are necessary to identify sufficient preparation procedures.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. District Court Decision Affirmed in U.S. Lovenox(R) (enoxaparin sodium) Patent Infringement Case
2. Frito-Lay Launches Low Sodium Versions of its Top Selling Snack Chips
3. Sodium Content Foods and Beverages Gain Revenues as Americans are Embracing Low- and No-Sodium Campaigns
4. Roxane Laboratories, Inc. Announces the Launch of Balsalazide Disodium Capsules, 750mg
5. AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium
6. Data Show Vaprisol(R) Is Effective & Safe in Promptly Increasing Serum Sodium Levels in Patients With Euvolemic or Hypervolemic Hyponatremia
7. Diffusion Pharmaceuticals Announces Results of Phase I Human Trial of Lead Drug Candidate, Trans Sodium Crocetinate (TSC) and Completion of a $4.5 Million Private Placement
8. Cutting Phosphate May Protect Kidney Patients From Heart Trouble
9. FDA Advisory Committee Votes in Favor of Earlier Use of Phosphate Binders in Stage 4 Kidney Disease Patients With Hyperphosphatemia
10. Genzyme Statement Regarding Results of FDA Advisory Committee Meeting on the Use of Phosphate Binders in Chronic Kidney Disease
11. Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... High Falls, NY & Salt Lake City, UT (PRWEB) , ... ... ... Frank Davis, Founder of Activz Whole-Food Nutrition , announced that the much-anticipated feature ... 5th on the New Really Cool Humans Amateur TV Network. , Each week, on ...
(Date:2/5/2016)... ... February 05, 2016 , ... The Muscular Dystrophy Association and ... launched the 14th annual “Appetite for a Cure” campaign on Feb. 1 to ... and related diseases that severely limit strength and mobility. , Now through ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President ... have signed a joint enrollment and degree completion agreement. The agreement, which ... baccalaureate degrees at FHU|Dickson. , The agreement allows students to be jointly ...
(Date:2/5/2016)... ... February 05, 2016 , ... US Sports Camps , official operators ... to direct high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in the ... Boston. , ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each January, ... to access the treadmills. It’s a predictable trend. After the excesses of November and ... in shape by joining gyms, starting new walking or running routines, or signing up ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... NEW YORK , Feb. 4, 2016   Bernstein ... has been filed in the United States District Court for ... of a class (the "Class") consisting of all persons or ... or the "Company") (NASDAQ: INSY ) from March 3, ... charges Insys and certain of its officers with violations of ...
(Date:2/4/2016)... , Feb. 4, 2016 Wegener ... Global Markets Direct,s, ,Wegener Polyangiitis - Pipeline ... Wegener Polyangiitis,s therapeutic pipeline. This report provides ... Polyangiitis, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ...
(Date:2/4/2016)... , Feb. 4, 2016 Summary ... common cancer and the most common cancer in women ... the disease exceedingly prevalent. The number of women diagnosed ... decades, but the number of deaths has declined due ... cancer treatment has been revolutionized in the past four ...
Breaking Medicine Technology: