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How does immune globulin therapy work? Now is the time to find out
Date:11/21/2012

asaki's disease, kidney transplant, Guillain-Barr syndrome, myasthenia gravis, graft-versus-host disease and chronic lymphocytic leukemia.

Dr. Gelfand and others believe that there are probably several mechanisms responsible for the benefits of IVIG. While antibodies have a primary binding site that they use to detect and clear hazardous proteins, they also have several other binding sites that interact with cells and soluble proteins that influence inflammatory and immune processes. IVIG also contains soluble proteins, including cytokines and chemokines, that could contribute to its beneficial effects.

While some progress has been made in understanding the beneficial mechanisms of IVIG, no definitive proteins have been discovered that could serve as substitute treatments.

"With a growing list of diseases that respond to IVIG treatments and its potential use for Alzheimer's disease, demand for IVIG will soon outstrip our ability to collect and provide it to patients in need," said Dr. Gelfand. "Now is the time to accelerate and focus our efforts on understanding IVIG's extraordinary actions."


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Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

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