Navigation Links
How does immune globulin therapy work? Now is the time to find out
Date:11/21/2012

Immune globulin replacement began decades ago as a treatment for patients who could not make their own protective antibodies, but has proven to have much broader benefits than originally expected. With new uses regularly being discovered for this limited and expensive resource, including as a potential treatment for Alzheimer's disease, now is the time to discover exactly how intravenous immune globulin (IVIG) treatments work, and to engineer a protein that can provide similar benefits, writes Erwin Gelfand, MD, chair of pediatrics at National Jewish Health in the November 22, 2012, issue of the New England Journal of Medicine.

"It has been a challenge to understand exactly how IVIG provides its antiinflammatory and immunomodulatory benefits," said Dr. Gelfand. "We need to figure it out so we can bring this treatment to more people who have no other options for treating their conditions."

Dr. Gelfand is an internationally recognized expert on immune deficiencies. In the late 1960s he was among the first to successfully perform a bone-marrow transplant for severe combined immune deficiency. He has used IVIG for decades to treat patients with inflammatory and autoimmune diseases.

Intravenous immune globulin solutions are prepared from the pooled plasma of thousands of healthy blood donors. Thus, it carries a tremendous diversity of antibodies, which can help defend against a wide variety of pathogens. It was originally introduced in the 1950s as a treatment to replace the missing disease-fighting antibodies in patients whose immune deficiencies left them vulnerable to infections.

Fairly quickly, however, it became apparent that its benefits extended beyond simple antibody replacement. In a patient with an autoimmune blood disease, it successfully restored blood platelet numbers, cells that help clot blood. Since then dozens of immune and inflammatory diseases have been shown to benefit from IVIG treatment, including Kawasaki's disease, kidney transplant, Guillain-Barr syndrome, myasthenia gravis, graft-versus-host disease and chronic lymphocytic leukemia.

Dr. Gelfand and others believe that there are probably several mechanisms responsible for the benefits of IVIG. While antibodies have a primary binding site that they use to detect and clear hazardous proteins, they also have several other binding sites that interact with cells and soluble proteins that influence inflammatory and immune processes. IVIG also contains soluble proteins, including cytokines and chemokines, that could contribute to its beneficial effects.

While some progress has been made in understanding the beneficial mechanisms of IVIG, no definitive proteins have been discovered that could serve as substitute treatments.

"With a growing list of diseases that respond to IVIG treatments and its potential use for Alzheimer's disease, demand for IVIG will soon outstrip our ability to collect and provide it to patients in need," said Dr. Gelfand. "Now is the time to accelerate and focus our efforts on understanding IVIG's extraordinary actions."


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Related medicine news :

1. How does the immune system fight off threats to the brain? New research yields fresh insight
2. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
3. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
4. Rutgers team discovers novel approach to stimulate immune cells
5. Scientists study serious immune malfunction
6. Babies susceptibility to colds linked to immune response at birth
7. Reactions to HIV drug have autoimmune cause, reports AIDS journal
8. First study to suggest that the immune system may protect against Alzheimers changes in humans
9. Belly Membrane May Regulate Immune System, Mouse Study Finds
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. Researchers reveal crucial immune fighter role of the STING protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2017)... ... January 13, 2017 , ... According to a December 9 ... may lower the risk of type 2 diabetes, Alzheimer’s, and cardiovascular disease. Southern ... wellness benefits linked to a Mediterranean diet are only some of the many ...
(Date:1/13/2017)... ... 2017 , ... A January 10 article in the Daily Star ... publication, with an emphasis on some new techniques that the publication says are becoming ... more casually to his patients and colleagues as Dr. J, comments that the best ...
(Date:1/13/2017)... ... January 13, 2017 , ... People who have sensitive teeth are about ... they brush their teeth. Sadly, most dental hygiene products in the market contain chemical ... For these people, continuing their daily oral care routine to keep their teeth white ...
(Date:1/13/2017)... ... 2017 , ... The Joint Corp. was recently ranked in ... by entrepreneurs and franchisors as a top competitive measurement, the Franchise 500® ranked ... strength and stability, growth rate, and brand power. , “It is always an ...
(Date:1/13/2017)... ... January 13, 2017 , ... One way to obtain a green ... if they can show their work is in the national interest. There are two ... having to be sponsored by an employer; and 2) the submission is made directly ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... -- Stock-Callers is currently reviewing the following Medical ... WMGI ), Varian Medical Systems Inc. (NYSE: ... and NuVasive Inc. (NASDAQ: NUVA ). These companies ... negative finish on Thursday, January 12 th , 2017, with ... of health care companies in the S&P 500 were down ...
(Date:1/13/2017)... Jan. 13, 2017 Wichita Laser Clinic ... laser treatments to Wichita, Kansas ... advanced treatments for skin rejuvenation, getting rid of unwanted ... and vascular lesions. "Since being in the ... Wichita for laser tattoo removal ...
(Date:1/13/2017)... Jan. 13, 2017  Secretary of Health Karen ... and community members at Misericordia University and discussed the ... Pennsylvania . "The opioid ... so far in my professional career," Secretary Murphy said. ... been hit hard by heroin and prescription opioid overdoses. ...
Breaking Medicine Technology: