Navigation Links
How does fibrosis occur in Crohn's disease?
Date:1/30/2013

New research has shown that a protein, known as IL-13, could be the key to the development of fibrosis in Crohn's disease. This breakthrough could help to advance new medicines to treat people suffering with the disease.

Crohn's disease is a chronic, debilitating condition characterised by inflammation and ulceration occurring at any point in the gastrointestinal tract. Currently there is no cure. One of the major complications of Crohn's disease is the development of fibrosis hardening and thickening in the bowel wall. This causes the intestine to lose its mobility and it eventually becomes so narrow that food and faeces are unable to pass.

Fibrosis occurs when there is an overproduction of the proteins which are normally involved in the tissue healing process, including collagens.

The research team, led by the School of Veterinary Sciences at the University of Bristol, found an increase in collagen synthesis and a lack of control of collagen deposition in fibrotic intestine taken from Crohn's disease patients when compared to normal intestine. The researchers believe that this is related to an increase in a soluble mediator, interleukin 13 (IL-13), previously identified as promoting fibrosis in the lung, liver and kidney.

Increased levels of IL-13 were found in fibrotic Crohn's gut when compared to normal gut, and tissue culture experiments showed that IL-13 reduced factors necessary to prevent inappropriate collagen deposition.

Dr Jenny Bailey, a researcher in the School of Veterinary Sciences at the University of Bristol, said: "We have identified a novel population of IL-13-producing cells which, in intestinal samples, were found at very high levels in fibrotic muscle. We believe these cells are key to the development of fibrosis.

"Understanding how fibrosis occurs will help us to develop new medicines to treat patients."

Since many patients developing fibrosis will require surgery,
'/>"/>

Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
44-011-733-17276
University of Bristol
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists identify new strategy to fight deadly infection in cystic fibrosis
2. Impaired blood vessel function found in cystic fibrosis patients
3. Researchers implicate well-known protein in fibrosis
4. Game changer for arthritis and anti-fibrosis drugs
5. Cystic fibrosis patients of low SES are less likely to be accepted for lung transplant
6. New drug successfully halts fibrosis in animal model of liver disease
7. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
8. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
9. Study evaluates use of inhaled saline for young children with cystic fibrosis
10. Early menopause may occur in women with BRCA gene, new study finds
11. Preventable Surgical Errors Continue to Occur: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... NV (PRWEB) September 30, 2014 Elevate ... helping people perform better in and out of the gym ... memory has caught the attention of Shane Michaels, prompting an ... grind, fatigue is the reason most people simply just don’t ... that means staying focused at work, getting the motivation to ...
(Date:9/30/2014)... 2014 VisitandCare.com reports that ... gone up more than 79 percent in 2014, marking ... also reported total revenue tripled for its entirety of ... professional strategy has allowed them to partner with ... patient comfort and privacy — with state-of-the-art surgical atmospheres ...
(Date:9/30/2014)... 2014 Hospice & Palliative Care ... Celebration” gala, honoring three outstanding individuals for their ... to provide extraordinary and dignified comfort, care and ... or life-limiting illness. , The event was held ... and recognized William (Bill) J. McGuinness, Director of ...
(Date:9/30/2014)... September 30, 2014 Regenerative Medicine Solutions ... new clinics in Nashville, Tennessee. RMS welcomes the launch ... and the expansion of a new treatment center for ... the Sleep Apnea Institute to Nashville, the hope is ... sleep apnea: both diagnosed and undiagnosed. With Nashville being ...
(Date:9/30/2014)... Dr. Karl R.O.S. Johnson, DC, has ... of care that is dramatically improving the health and ... Neurology & Nutrition—applies a proprietary, multi-dimensional approach that goes ... sources of inflammation, neurology of the joint and neurology ... the brain to the spine, to the legs, knees ...
Breaking Medicine News(10 mins):Health News:Elevate: Review Exposes Blue Star Nutraceutical’s Latest Supplement for Ultimate Brain Function, Focus, and Energy 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:Hospice & Palliative Care of Westchester Honors Outstanding Individuals at Annual ‘In Celebration’ Gala 2Health News:Regenerative Medicine Solutions Expanding 2Health News:Newly Developed Program Eases Chronic Knee Pain without Surgery and in as Little as Two Days 2Health News:Newly Developed Program Eases Chronic Knee Pain without Surgery and in as Little as Two Days 3
... that the U.S. Food and Drug Administration has approved ... prostate cancer patients, marks the beginning of an era ... the standard therapeutic arsenal against cancer, say Dana-Farber Cancer ... effectiveness in patients. The study the results ...
... ... Illness (NAMI), NAMIWalks help raise funds for local programs. , ... (PRWEB) -- May is Mental Health Month. This weekend, Saturday ... NAMIWalks to raise public awareness about facts concerning mental illness and the ...
... from all drugs used to prevent organ rejection, researchers ... type of drug treatment used to prevent organ rejection ... new study finds. , Kidney transplant patients are at ... use of immunosuppressive drugs to prevent organ rejection. In ...
... ... gastroenterologists from around the world to launch the first international “World IBD Day” dedicated ... conference (May 2 -5) in New Orleans. , ... New York, New York (Vocus) April 29, 2010 -- ...
... of ill people triggered greater response than pictures of gun-wielding ... a sick person may give your immune system a boost, ... sets of slides on two different days. The first set ... either a slideshow that showed photos of people with pox, ...
... This release is available in French . ... in Immunology and Cancer (IRIC) of the Universit de Montral ... ribonucleic acid (RNA) engineering laboratory in Canada. Led by Franois ... of Gerardo Ferbeyre, biochemistry researcher with the Faculty of Medicine ...
Cached Medicine News:Health News:Dana-Farber/Provenge: Approval of prostate cancer immunotherapy-new era of cancer treatments 2Health News:Dana-Farber/Provenge: Approval of prostate cancer immunotherapy-new era of cancer treatments 3Health News:NAMIWalks Kicks-off “Mental Health Month”; Fun Events that Support Serious Work 2Health News:Cancer Risk After Kidney Transplant Unaffected by Type of Drug Treatment 2Health News:First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease 2Health News:First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease 3Health News:First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease 4Health News:First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease 5Health News:Cells programmed to cure and even prevent cancer 2
(Date:9/30/2014)... Quebec , Sept. 30, 2014 Valeant ... TSX: VRX) today announced that the company,s ... Letter from the U.S. Food and Drug Administration (FDA) ... Company,s records with regards to Sculptra Aesthetic injectable, which ... Warning Letter pertains to the management of Valeant,s contract manufacturers ...
(Date:9/30/2014)... , Sept. 30, 2014  HealthLoop® released an ... with HealthKit in iOS 8 and allows people to ... The app harnesses native iOS technologies to enhance the ... a robust connection with their doctors between visits. ... and the data they collect is exciting," says HealthLoop ...
(Date:9/30/2014)... MOUNTAIN VIEW, Calif. , Sept. 30, 2014 ... oncology tissue diagnostics market, Frost & Sullivan recognizes ... the Roche Group, with the 2014 North American ... Adherence to strict quality practices along with a ... made Ventana a global leader in tissue-based cancer ...
Breaking Medicine Technology:Valeant Pharmaceuticals' Bridgewater Location Receives Warning Letter From FDA 2HealthLoop Integrates with Apple's HealthKit Enabling Patients to Share Health Data with Their Doctors Right from their iPhone 2Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 2Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 3Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 4
... and Drug Administration today issued new guidance that advises ... to administer influenza vaccinations. Based on this advice, The ... use of such clinical devices at all pharmacies and ... family of pharmacies and The Little Clinic locations will ...
... 21, 2011 Boca Pharmacal, Inc., today announced that it ... Drug Application (ANDA) for Glycopyrrolate Tablets USP, 1 mg and ... and Robinul Forte Tablets, 2 mg, distributed by Shionogi Pharma, ... in the treatment of peptic ulcers. "We,re up ...
Cached Medicine Technology:Boca Pharmacal Receives FDA Approval on Glycopyrrolate Tablets 2
... Streptavidin magnetic beads are designed ... biotinylated molecules such as DNA, ... cell lysates or hybridization reactions. ... dispersed, it can also be ...
... Streptavidin magnetic beads are ... covalently coupled to a ... substrates can be useful ... experiments including mRNA isolation ...
... For the detection P.falciparum ... and pan specific pLDH, for differentiation ... other malarial species viz P.vivax ... P. malariae and for the ...
The Cellabs Rapimal (P.f.) is a rapid and sensitive in vitro immunochromatography assay system for the detection of HRP-2 antigen produced by P. falciparum at the merozoite (red blood cell) stage o...
Medicine Products: