Navigation Links
How does aging affect cancer? Einstein awarded $2.8m grant to answer NCI 'provocative question'
Date:10/21/2013

October 21, 2013 -- (BRONX, NY) -- Gene mutations increase as people age, which helps explain why cancer usually strikes older people. But what other consequences of aging promote cancer development or protect against it?

This is one of the 24 "Provocative Questions" that the National Cancer Institute (NCI) wants researchers to address. Now, a team of scientists at Albert Einstein College of Medicine of Yeshiva University has received a $2.8 million grant from NCI to investigate this question. The researchers will examine the role of epigenetics in causing lung cancer in people of different ages.

Epigenetic changes involve chemical "tags" that turn genes on or off without affecting the genes' underlying DNA sequences. As with gene mutations, epigenetic tags accumulate with age, and their presence on genes can be influenced by environmental factors such as what you eat and the quality of the air you breathe. Scientists now recognize that aberrant epigenetic tagging plays a major role in causing many types of cancer, but just how epigenetic changes influence cancer risk still isn't well understood.

The grant award will allow Einstein researchers to focus on a vexing question related to smoking risk.

"Why do some smokers get lung cancer in their 40s while others who smoke their whole lives are protected until very old age?" asked Jan Vijg, Ph.D., professor and chair of genetics and the Lola and Saul Kramer Chair in Molecular Genetics at Einstein and co-principle investigator on the grant. "We will look at how a person's epigenome the entire set of chemical tags that decorate their genes modulates the effect of aging on lung cancer risk."

Dr. Vijg, along with co-principal investigators Simon Spivack, M.D., M.P.H., Adam Auton, D.Phil., and Yousin Suh, Ph.D., will examine lung samples from four groups of former smokers: young smokers with lung cancer, aged smokers without lung cancer, as well as young smokers without cancer and older smokers with cancer.

In studying these lung-tissue samples, the researchers will focus on an important class of epigenetic tag: the methyl groups that attach to genes. Since aging and smoking interact to determine lung-cancer risk, the researchers will determine if this interaction is influenced by the pattern of methyl groups they observe on genes as well as by the DNA sequences of the genes themselves.

One goal of this work is to identify new epigenetic or genetic biomarkers that can help predict a person's risk of developing lung cancer. And since epigenetic modifications of genes are reversible, another goal is to develop ways of modifying peoples' epigenome to reduce their lung-cancer risk and perhaps delay aging as well.

Tissue samples will be provided by surgeons at Montefiore Medical Center, the University Hospital for Einstein. Dr. Spivack is professor of medicine, of epidemiology & population health and of genetics at Einstein and chief of pulmonary medicine at Einstein and Montefiore. Dr. Auton is assistant professor of genetics at Einstein. Dr. Suh is professor of genetics and of medicine at Einstein.

NCI's "Provocative Questions" is a novel funding initiative designed to ignite investigations into 24 promising but neglected or unexplored areas of research. Answering the questions would dramatically enhance ongoing efforts to prevent, treat and cure cancer.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Learning new skills keeps an aging mind sharp
2. Anti-Wrinkle and Anti-Aging Ingredients Featured in Face Whisperer® Line from Sublime Beauty® on Sale
3. Aging expert Colin Milner addresses United Nations' findings by offering "Nine Principles" for improving society's response to population aging
4. Medical imaging professionals develop safety checklist to improve pediatric radiography
5. Over-the-Counter As Effective As Rx at Managing Post-Tonsillectomy Pain
6. Over-the counter as effective as Rx at managing post-tonsillectomy pain
7. mHealth Alliance and Pfizer Call for Collective Action on Mobile Health for Healthy Aging
8. Global Metal Packaging Industry
9. Global Medical Imaging Reagents Market 2016 Forecast Report Now Available at ReportsnReports.com
10. Kollagen Intensiv the Newest Natural Formula is Now Available to Reduce the Appearance of Aging Signs, Dark Circles and Wrinkles
11. Join GSA in New Orleans for the nations premier aging conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, ... organization dedicated to helping service members that have been wounded in battle and their ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
Breaking Medicine Technology: