Navigation Links
How does aging affect cancer? Einstein awarded $2.8m grant to answer NCI 'provocative question'
Date:10/21/2013

October 21, 2013 -- (BRONX, NY) -- Gene mutations increase as people age, which helps explain why cancer usually strikes older people. But what other consequences of aging promote cancer development or protect against it?

This is one of the 24 "Provocative Questions" that the National Cancer Institute (NCI) wants researchers to address. Now, a team of scientists at Albert Einstein College of Medicine of Yeshiva University has received a $2.8 million grant from NCI to investigate this question. The researchers will examine the role of epigenetics in causing lung cancer in people of different ages.

Epigenetic changes involve chemical "tags" that turn genes on or off without affecting the genes' underlying DNA sequences. As with gene mutations, epigenetic tags accumulate with age, and their presence on genes can be influenced by environmental factors such as what you eat and the quality of the air you breathe. Scientists now recognize that aberrant epigenetic tagging plays a major role in causing many types of cancer, but just how epigenetic changes influence cancer risk still isn't well understood.

The grant award will allow Einstein researchers to focus on a vexing question related to smoking risk.

"Why do some smokers get lung cancer in their 40s while others who smoke their whole lives are protected until very old age?" asked Jan Vijg, Ph.D., professor and chair of genetics and the Lola and Saul Kramer Chair in Molecular Genetics at Einstein and co-principle investigator on the grant. "We will look at how a person's epigenome the entire set of chemical tags that decorate their genes modulates the effect of aging on lung cancer risk."

Dr. Vijg, along with co-principal investigators Simon Spivack, M.D., M.P.H., Adam Auton, D.Phil., and Yousin Suh, Ph.D., will examine lung samples from four groups of former smokers: young smokers with lung cancer, aged smokers without lung cancer, as well as young smokers without cancer and older smokers with cancer.

In studying these lung-tissue samples, the researchers will focus on an important class of epigenetic tag: the methyl groups that attach to genes. Since aging and smoking interact to determine lung-cancer risk, the researchers will determine if this interaction is influenced by the pattern of methyl groups they observe on genes as well as by the DNA sequences of the genes themselves.

One goal of this work is to identify new epigenetic or genetic biomarkers that can help predict a person's risk of developing lung cancer. And since epigenetic modifications of genes are reversible, another goal is to develop ways of modifying peoples' epigenome to reduce their lung-cancer risk and perhaps delay aging as well.

Tissue samples will be provided by surgeons at Montefiore Medical Center, the University Hospital for Einstein. Dr. Spivack is professor of medicine, of epidemiology & population health and of genetics at Einstein and chief of pulmonary medicine at Einstein and Montefiore. Dr. Auton is assistant professor of genetics at Einstein. Dr. Suh is professor of genetics and of medicine at Einstein.

NCI's "Provocative Questions" is a novel funding initiative designed to ignite investigations into 24 promising but neglected or unexplored areas of research. Answering the questions would dramatically enhance ongoing efforts to prevent, treat and cure cancer.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Learning new skills keeps an aging mind sharp
2. Anti-Wrinkle and Anti-Aging Ingredients Featured in Face Whisperer® Line from Sublime Beauty® on Sale
3. Aging expert Colin Milner addresses United Nations' findings by offering "Nine Principles" for improving society's response to population aging
4. Medical imaging professionals develop safety checklist to improve pediatric radiography
5. Over-the-Counter As Effective As Rx at Managing Post-Tonsillectomy Pain
6. Over-the counter as effective as Rx at managing post-tonsillectomy pain
7. mHealth Alliance and Pfizer Call for Collective Action on Mobile Health for Healthy Aging
8. Global Metal Packaging Industry
9. Global Medical Imaging Reagents Market 2016 Forecast Report Now Available at ReportsnReports.com
10. Kollagen Intensiv the Newest Natural Formula is Now Available to Reduce the Appearance of Aging Signs, Dark Circles and Wrinkles
11. Join GSA in New Orleans for the nations premier aging conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... The American Board of Family Medicine's (ABFM) Board of Directors has selected ... Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the position ... the end of 2018. Upon assuming the role of President and CEO on January ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of ... part of a disaster drill on October 3rd. , Apple Rehab participated with the ... as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/18/2017)... , Pa. and KALAMAZOO, Mich. , ... Allentown, Penn. , and OptiMed Specialty Pharmacy of ... business partnership to offer a strategic hub service that ... Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, and ... A spirometer is a medical device used to ...
Breaking Medicine Technology: