Navigation Links
How does P wave dispersion change in patients with Wilson's disease?
Date:3/18/2008

Wilson's disease is a severe inherited metabolic disorder, which is associated with intracellular copper overload and multiple organ involvement. Main cardiac manifestations in Wilson's disease include arrhythmias and cardiac failure. Recently, researchers at the Ankara Yksek Ihtisas Hospital and in Ankara University Faculty of Medicine investigated P wave dispersion (PWD) as a non-invasive marker of intra-atrial conduction disturbance in patients with Wilson's disease.

This research, led by Dr. Nurcan Arat is to be published on February 28, 2008 in the World Journal of Gastroenterology.

All the patients were asymptomatic on cardiological examination and had no rhythm disturbances in electrocardiography. Left ventricular and left atrial diameters and left ventricular function were similar in both groups. The Wilson's disease patients had a significantly higher P wave dispersion when compared with the controls. This significant dispersion may correlate to atrial conductance abnormalities like atrial fibrillation.

PWD was significantly higher in Wilson's patients than in the control group. PWD was significantly correlated with the age at diagnosis and serum copper level in patients with Wilson's disease. The team was not able to find any statistically significant correlation between PWD and other clinical and echocardiographic evaluations.

Dr. Arat, leader of the research team, underlined the importance of finding a new non-invasive tool, PWD, to foresee the possible devastating cardiac manifestations like arrhythmias which even asymptomatic patients can suffer from.

Though Wilson's disease is a rare genetic disorder and not a general health problem, the population within this study is large enough to take lessons for the future. Adopting this methodology, both affected people and care giving physicians will have the opportunity to evaluate the risk of cardiac disturbances.

To generate a Wilson's disease population is a tough task. The collaborators within the study did manage, however, to gather a non-negligible number of patients together in Turkey. This clinical research was performed using the resources of Ankara Yksek Ihtisas Hospital. Ankara University Department of Gastroenterology supported them with recruiting additional Wilson's disease patients to the study.

Further research and long term follow-up will confirm and explain the positive PWD data in Wilson's disease patients according to findings of this initiative study.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Food Bank For New York City Acquires FoodChange
2. Hospitals Agree to Pay Fees in Exchange for More Income, but Consumers in the Dark About What Theyll be Charged Under Nunez Plan
3. New AHIP Report Takes a Ten Year Look at the Unintended Consequences of State Efforts to Change the Insurance Market
4. Women less likely than men to change habits that increase heart disease risk
5. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
6. Meritain Health Announces Name Change for Acquired Companies
7. Arbios Announces Management Changes
8. Most patients who have male-to-female sex-change surgery are happy, despite complications
9. Diet Change Can Curb Fatty Liver Disease
10. Partnership to Fight Chronic Disease Announces Ideas for Change in Health Care
11. 4-Star Gen. Barry McCaffrey, Former U.S. Drug Czar, & Countrys Top Drug Treatment CEO Barry Karlin to Keynote Palm Beach, FL National Moment Of Change Intervention Conference:
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... 2016 , ... In its newly released Infusion Therapy Standards ... be used to ensure patient safety when placing an IV catheter. A key ... use of vein visualization technology in patients with difficult venous access or after ...
(Date:2/13/2016)... ... 2016 , ... In the early or “honeymoon” stage of a relationship, couples ... of their way to be romantic, and may exaggerate a strength or two in ... dating profile. , A recent study from Queendom.com , however, suggests that ...
(Date:2/12/2016)... ... February 12, 2016 , ... Mystic Buddha Publishing House presents ... SKies Buddha, the biography of Rama - Dr. Frederick Lenz. , According ... love of a Buddhist teacher for teaching and helping others. Valentine’s Day celebrates ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma community ... hosted over 250 members of South Florida’s philanthropic community at its 10th anniversary ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Each year, ... will be held in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical ... see new therapy products in action, learn more about their chosen field and network ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016   Health 2.0 , the premiere showcase ... announced today " 10 Year Global Retrospective ", a ... the past ten years.   --> ... 2.0 has served as the preeminent thought-leader in the ... of technologies, companies, innovators, and patient-activists through an array ...
(Date:2/11/2016)...  NOIT™ Research LLC, a private, leading-edge autism research ... to assist needy families in obtaining one of its ... February 10, 2016 and March 31, 2016, the company ... NOIT is an auditory stimulus that plays a key ... Beth Shier , NOIT Research director. ...
(Date:2/11/2016)... WILMINGTON, N.C. , Feb. 11, 2016 /PRNewswire/ ... a leading provider of custom manufacturing and development ... announces expanded sterile fill-finish capabilities and capacity in ... Substantial growth in demand has driven several recent ... in 2001 it had one filling line with ...
Breaking Medicine Technology: