Navigation Links
How does P wave dispersion change in patients with Wilson's disease?
Date:3/18/2008

Wilson's disease is a severe inherited metabolic disorder, which is associated with intracellular copper overload and multiple organ involvement. Main cardiac manifestations in Wilson's disease include arrhythmias and cardiac failure. Recently, researchers at the Ankara Yksek Ihtisas Hospital and in Ankara University Faculty of Medicine investigated P wave dispersion (PWD) as a non-invasive marker of intra-atrial conduction disturbance in patients with Wilson's disease.

This research, led by Dr. Nurcan Arat is to be published on February 28, 2008 in the World Journal of Gastroenterology.

All the patients were asymptomatic on cardiological examination and had no rhythm disturbances in electrocardiography. Left ventricular and left atrial diameters and left ventricular function were similar in both groups. The Wilson's disease patients had a significantly higher P wave dispersion when compared with the controls. This significant dispersion may correlate to atrial conductance abnormalities like atrial fibrillation.

PWD was significantly higher in Wilson's patients than in the control group. PWD was significantly correlated with the age at diagnosis and serum copper level in patients with Wilson's disease. The team was not able to find any statistically significant correlation between PWD and other clinical and echocardiographic evaluations.

Dr. Arat, leader of the research team, underlined the importance of finding a new non-invasive tool, PWD, to foresee the possible devastating cardiac manifestations like arrhythmias which even asymptomatic patients can suffer from.

Though Wilson's disease is a rare genetic disorder and not a general health problem, the population within this study is large enough to take lessons for the future. Adopting this methodology, both affected people and care giving physicians will have the opportunity to evaluate the risk of cardiac disturbances.

To generate a Wilson's disease population is a tough task. The collaborators within the study did manage, however, to gather a non-negligible number of patients together in Turkey. This clinical research was performed using the resources of Ankara Yksek Ihtisas Hospital. Ankara University Department of Gastroenterology supported them with recruiting additional Wilson's disease patients to the study.

Further research and long term follow-up will confirm and explain the positive PWD data in Wilson's disease patients according to findings of this initiative study.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Food Bank For New York City Acquires FoodChange
2. Hospitals Agree to Pay Fees in Exchange for More Income, but Consumers in the Dark About What Theyll be Charged Under Nunez Plan
3. New AHIP Report Takes a Ten Year Look at the Unintended Consequences of State Efforts to Change the Insurance Market
4. Women less likely than men to change habits that increase heart disease risk
5. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
6. Meritain Health Announces Name Change for Acquired Companies
7. Arbios Announces Management Changes
8. Most patients who have male-to-female sex-change surgery are happy, despite complications
9. Diet Change Can Curb Fatty Liver Disease
10. Partnership to Fight Chronic Disease Announces Ideas for Change in Health Care
11. 4-Star Gen. Barry McCaffrey, Former U.S. Drug Czar, & Countrys Top Drug Treatment CEO Barry Karlin to Keynote Palm Beach, FL National Moment Of Change Intervention Conference:
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
Breaking Medicine Technology: