Navigation Links
How does P wave dispersion change in patients with Wilson's disease?
Date:3/18/2008

Wilson's disease is a severe inherited metabolic disorder, which is associated with intracellular copper overload and multiple organ involvement. Main cardiac manifestations in Wilson's disease include arrhythmias and cardiac failure. Recently, researchers at the Ankara Yksek Ihtisas Hospital and in Ankara University Faculty of Medicine investigated P wave dispersion (PWD) as a non-invasive marker of intra-atrial conduction disturbance in patients with Wilson's disease.

This research, led by Dr. Nurcan Arat is to be published on February 28, 2008 in the World Journal of Gastroenterology.

All the patients were asymptomatic on cardiological examination and had no rhythm disturbances in electrocardiography. Left ventricular and left atrial diameters and left ventricular function were similar in both groups. The Wilson's disease patients had a significantly higher P wave dispersion when compared with the controls. This significant dispersion may correlate to atrial conductance abnormalities like atrial fibrillation.

PWD was significantly higher in Wilson's patients than in the control group. PWD was significantly correlated with the age at diagnosis and serum copper level in patients with Wilson's disease. The team was not able to find any statistically significant correlation between PWD and other clinical and echocardiographic evaluations.

Dr. Arat, leader of the research team, underlined the importance of finding a new non-invasive tool, PWD, to foresee the possible devastating cardiac manifestations like arrhythmias which even asymptomatic patients can suffer from.

Though Wilson's disease is a rare genetic disorder and not a general health problem, the population within this study is large enough to take lessons for the future. Adopting this methodology, both affected people and care giving physicians will have the opportunity to evaluate the risk of cardiac disturbances.

To generate a Wilson's disease population is a tough task. The collaborators within the study did manage, however, to gather a non-negligible number of patients together in Turkey. This clinical research was performed using the resources of Ankara Yksek Ihtisas Hospital. Ankara University Department of Gastroenterology supported them with recruiting additional Wilson's disease patients to the study.

Further research and long term follow-up will confirm and explain the positive PWD data in Wilson's disease patients according to findings of this initiative study.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Food Bank For New York City Acquires FoodChange
2. Hospitals Agree to Pay Fees in Exchange for More Income, but Consumers in the Dark About What Theyll be Charged Under Nunez Plan
3. New AHIP Report Takes a Ten Year Look at the Unintended Consequences of State Efforts to Change the Insurance Market
4. Women less likely than men to change habits that increase heart disease risk
5. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
6. Meritain Health Announces Name Change for Acquired Companies
7. Arbios Announces Management Changes
8. Most patients who have male-to-female sex-change surgery are happy, despite complications
9. Diet Change Can Curb Fatty Liver Disease
10. Partnership to Fight Chronic Disease Announces Ideas for Change in Health Care
11. 4-Star Gen. Barry McCaffrey, Former U.S. Drug Czar, & Countrys Top Drug Treatment CEO Barry Karlin to Keynote Palm Beach, FL National Moment Of Change Intervention Conference:
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... (PRWEB) , ... August 18, ... ... d/b/a Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider of ... entered into a definitive agreement to purchase Unitrans International Corporation, a division ...
(Date:8/18/2017)... NY (PRWEB) , ... August 18, 2017 , ... ... of “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the ... available for individuals with hearing impairments and shares the latest innovations in hearing ...
(Date:8/18/2017)... McLean, VA (PRWEB) , ... August 18, 2017 ... ... offers asset protection services and financial consultations to communities throughout the greater DC ... Semper K9 with the goal of rescuing local animals and training them to ...
(Date:8/18/2017)... ... August 18, 2017 , ... MLM Insurance Group, a Miami ... southern Florida, is working to support the Take Stock In Children Foundation during ... families. , The Take Stock In Children Foundation (TSC) offers guidance and assistance ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a Texas based insurance management ... spearheading a regional charity campaign organized to provide support to Christina Upchurch and her ... year, Christina and her children returned from out of town to find her husband ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... Services, Inc. (NYSE: WST ) today announced ... financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, a record high, ... constant currency (organic) grew by 3.9%. ... in the prior-year quarter. Second-quarter 2017 adjusted diluted EPS ...
(Date:7/26/2017)... SINGAPORE , July 27, 2017  Radium Medical Aesthetics, a ... LASEMD, designed to delay aging by effectively addressing several skin conditions ... the skin to become rougher and more fragile. The skin becomes ... the unavoidable exposure to the harmful UV rays from the sun ... hyperpigmentation. ...
(Date:7/26/2017)... , July 26, 2017 The Galien ... Prix Galien USA Award Nominees. Counted ... Prix Galien Award recognizes outstanding biomedical and technology product achievement ... To qualify, each candidate must be U.S. Food ... five years and demonstrate tremendous potential to impact human health. ...
Breaking Medicine Technology: