Navigation Links
How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?
Date:1/16/2008

Many hepatocellular carcinoma (HCC) patients in China may be treated with Traditional Chinese medicine (TCM). Some say it works, others doubt its effectiveness. These stated that a research group in China had found TCM can down-regulate the expression of PTEN in HCC, which may suppress tumor cell growth and regulate tumor cell invasion and metastasis.

A research article published on January 7, 2008 in the World Journal of Gastroenterology (volume 14, issue 1) addresses this problem. The research group imbedded hepatoma carcinoma tissue in the livers of 48 male athymic mice. The mice were distributed randomly into two groups: The chemotherapy group was treated by intragastric administration with FT207 (Tegafur). The TCM group was treated by intragastric administration with FZJDT (complex prescription of Chinese crude drug) that had been deliquated into 3 kinds of density as the low, middle, and high.

Four weeks later, the researchers found the TCM group had distinct superiority in their survival rate compared with the chemotherapy group. There was less tumor metastasis in the livers of the TCM group than in the chemotherapy group. Particularly the results of immunohistochemistry showed the intensity of PTEN (Phosphatase and Tensin Homolog deleted on Chromosome 10) in the TCM group was higher than in the chemotherapy group.

PTEN was recently identified as a tumor suppressor gene by three American research teams. They found PTEN may suppress tumor cell growth and regulate tumor cell invasion and metastasis through inhibiting many signal pathways of cell proliferation.

FZJDT has been widely used to treat HCC for years in The First Affiliated Hospital of Sun Yat-Sen University. Just what is the mechanism of the Chinese herbs that strengthens the body's resistance and removes toxic substances? Our research showed TCM could markedly increase expression of PTEN in the athymic mice, compared with the chemotherapy group treated with FT207, indicating the anticancer mechanism of the TCM used in this study.

Mechanisms of TCM healing HCC may partially be explained by the enhancing of the expression of PTEN in the liver. The results of this study suggest a promising future for TCM as a combined therapy to treat HCC in China .


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. iNOS expression may links chronic biliary inflammation to malignant transformation
2. Biolytix to Offer Industrial Gene Expression Analysis and Genotyping Services Using Affymetrix GeneChip(R) Technology
3. Facial expressions have greater impact on kids with bipolar disorder
4. Flip-flopping gene expression can be advantageous
5. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
6. New study shows that therapeutic gene expression can be sustainable for 1 year
7. 10th Anniversary of Revolutionary Teaching Approach that Offers the Severely Disabled the Gift of Self-Expression - Through Painting
8. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
9. A new chemotherapeutic target for hepatocellular carcinoma
10. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
11. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 2017 , ... Judy Buchanan, co-owner of Serenity Natural Health ... says, “I am passionate about sharing Reiki as a holistic, complementary therapy with ... time.” , A Certified Medical Reiki™ Master trained by Raven Keys Medical Reiki™ ...
(Date:3/24/2017)... ... ... “End Time GPS”: a dauntless and enlightened study of the second-coming of Christ, ... of published author, Wesley Gerboth, a World War II veteran, with a highly-regarded reputation ... age ninety-one, he shares the Wisdom God bestowed upon him in this publication. ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... stories about real people of God in congregations across the United States. ... Presbyterian minister ordained in 1964 who has served congregations in seven states throughout ...
(Date:3/23/2017)... Greensboro, NC & Seattle, WA (PRWEB) , ... March 23, 2017 ... ... international public health emergency and now estimates that there could be four million Zika-related ... fastest growing epidemics to date with numbers of US cases reported per year skyrocketing ...
(Date:3/23/2017)... ... March 23, 2017 , ... The physicians of KSF ... the greater Houston Area. The new location is located at 2255 E. Mossy Oaks ... Springwoods Village. This newest location will provide patients living in the north Houston area ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of the ... 2022" report to their offering. ... The global wound care market was worth $24,482.9 million in ... during 2016-2022 Among the various wound care products type, the ... market in 2015. Among the various applications, surgical wound segment held the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Dental ... ... markets for Dental Implants in US$ Million. The report provides separate comprehensive ... , Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2015 through ...
(Date:3/24/2017)... 24, 2017 ShangPharma, a leading ... cost-effective drug development and discovery services, technology, ... industry, announced today the intent for a ... be consolidating the Contract Research Organizations (CRO) ... ChemPartner. These entities include ChemPartner Shanghai, ChemPartner ...
Breaking Medicine Technology: