Navigation Links
How do neural stem cells decide what to be -- and when?
Date:11/15/2010

SINGAPORE Researchers at Duke-NUS Graduate Medical School in Singapore have uncovered a novel feedback mechanism that controls the delicate balance of brain stem cells.

Zif, a newly discovered protein, controls whether brain stem cells renew themselves as stem cells or differentiate into a dedicated type of neuron (nerve cell).

In preclinical studies, the researchers showed that Zif is important for inhibiting overgrowth of neural stem cells in fruit flies (genus Drosophila) by ensuring that a proliferation factor (known as aPKC) maintains appropriate levels in neural stem cells.

"There is a Zif-related protein in humans, and its function remains to be analyzed," said senior and corresponding author Hongyan Wang, Ph.D. "Our finding has paved the way for future study of this human protein in the context of diseases, including glioblastomas, the most severe form of brain tumors."

She said it may be "possible to manipulate Zif function into a form of therapy against diseases, including cancer."

The study was published in the Nov. 16 issue of Developmental Cell journal.

The findings suggest that a lack of Zif protein expression correlates with neural stem cell overpopulation in Drosophila.

The mechanism is circular: Zif is a transcription factor that inhibits the manufacture of aPKC. But Zif can also be tagged with a phosphate by aPKC, which excludes Zif from the cell nucleus, and leads to Zif inactivation, which in turn means an overgrowth of stem cells.

"Next, we would like to investigate the mechanisms of neural stem cells' self-renewal in mammals, and we are looking for the right collaborators," Wang said. "We will also continue to use Drosophila as a powerful model system to uncover critical players in neural stem cell self-renewal so that we can understand the network involved in this regulation."


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Neuralstem updates ALS clinical trial progress
2. Neuralstem chief scientific officer to take part in World Stem Cell Summit plenary session
3. Neuralstem stem cells survive and differentiate into neurons in rats with stroke
4. Misfolded neural proteins linked to autism disorders
5. The neural basis of the depressive self
6. Hurts so good -- neural clues to the calming effects of self-harm
7. Neuralstem files FDA application for first chronic spinal cord injury stem cell trial
8. Human neural stem cells restore motor function in mice with chronic spinal cord injury
9. FDA approves first human neural stem cell clinical trial to treat brain tumors
10. Neuralstem updates clinical trial progress
11. Race and empathy matter on neural level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... has recently contributed a medical article to the newly revamped Cosmetic Town ... article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 ... , and OptiMed Specialty Pharmacy of Kalamazoo, ... offer a strategic hub service that expedites and streamlines ... personal spirometer, Spiro PD 2.0, and wellness management services.  ... is a medical device used to measure lung function ...
Breaking Medicine Technology: