Navigation Links
How do happiness and sadness circuits contribute to bipolar disorder?
Date:1/14/2013

Philadelphia, PA, January 14, 2013 Bipolar disorder is a severe mood disorder characterized by unpredictable and dramatic mood swings between the highs of mania and lows of depression. These mood episodes occur among periods of 'normal mood', termed euthymia.

Prior research has clearly shown that brain emotion circuitry is dysregulated in individuals diagnosed with bipolar disorder. It is thought that these disturbances impair one's ability to control emotion and contribute to mood episodes.

Continuing this line of research, the January 15th issue of Biological Psychiatry reports the results of a study conducted by scientists from Indiana University School of Medicine. These investigators used functional magnetic resonance imaging (fMRI) to investigate which areas of the brain showed abnormal activation while patients in different mood phases of bipolar disorder tried to control their response to emotional and non-emotional material.

This allowed them to analyze brain activation patterns based on patient mood (manic, depressed, or euthymic) and stimuli type (emotion versus no emotion and happy versus sad). Because medication effects on brain activation have been observed in some studies, the researchers recruited only unmedicated volunteers.

They found that bipolar depressed patients abnormally activated brain areas when they had to withhold responses to sad faces. Manic patients, on the other hand, had abnormal activation regardless of whether they were trying to withhold response to sad faces, happy faces or non-emotional material. Even the euthymic bipolar subjects showed abnormal activation of cortical areas of the brain while withholding responses to emotional faces.

These findings suggest that distinct circuit dysfunctions may contribute to different features of emotion dysregulation in bipolar disorder.

Professor and senior author Dr. Amit Anand said, "This study provides important informati
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Travel and Other Adventures Can Boost Happiness
2. Money Really Cant Buy Happiness, Study Finds
3. United Nations Adopts International Day of Happiness
4. Childhood Friendships May Be Key to Adult Happiness
5. Study finds gene that predicts happiness in women
6. New study examines how health affects happiness
7. Fidelity Investments Brings the Happiness of the Holidays to Five Educational First Steps Assisted Centers
8. Greg Reid of Napoleon Hill Foundation Makes a Special World Premier Announcement of His Latest Project (The Secret of Happiness) on the “Your Do Over” Podcast on iTunes
9. Simple mathematical computations underlie brain circuits
10. Songbirds shed light on brain circuits and learning
11. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount Labels ... a local organization that provides services to veterans and ... on a couple hundred acres in the hills of ... class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet shooting, ... ago to support U.S. Service men and women, police ...
(Date:12/22/2014)... 2014 7,178 small business owners and ... Friday shopping and opted instead to join Digital Marketer, ... for their 5th annual “Black Friday Boot Camp”. ... to attend the 5 hour online training event and ... to support two Central Texas based charities dedicated to ...
(Date:12/22/2014)... December 22, 2014 NAPW ... Professional Woman of the Year. Ms. Foley is recognized ... the largest, most-recognized networking organization of professional women in ... National Association of Professional Women is a powerfully vibrant ... Local Chapters. , “As a nurse, I felt like ...
(Date:12/22/2014)... Washington, DC (PRWEB) December 22, 2014 ... Nursing Leadership Conference, next month in San ... strategies to address dynamics that often stand in ... authority, and competition. , This premier faculty ... Center for Transformational Leadership, whose mission is to ...
(Date:12/21/2014)... an outstanding online supplier of wedding dresses and women’s ... of Cocktail Dresses for the winter 2014. All these ... trends. , “We take pride in releasing ... of them are offered at greatly discounted rates, up ... to offer a nice shopping experience for global customers.” ...
Breaking Medicine News(10 mins):Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:Stunning Cocktail Party Dresses from Weddingshe.com 2
... , MONDAY, Feb. 27 (HealthDay News) -- Rapid diagnostic ... flu season could lead to earlier treatment for patients and ... suggest. The 2012 flu season is just beginning and, ... 5 million people worldwide, experts say. Most patients will recover, ...
... news digest: , Summary of a study being ... Clinical Oncology , showing that women who underwent a once-common ... slightly lower on cognitive tests that measure word learning, memory ... cancer. While CMF is no longer the standard ...
... MONDAY, Feb. 27 (HealthDay News) -- If a luxurious-looking car ... That,s the message of a new observational study that contends ... cut off pedestrians and ignore stop-sign etiquette. The new ... experiments done by the researchers found that study participants ...
... By Jenifer Goodwin HealthDay Reporter , SUNDAY, Feb. ... cells from adult human ovaries that can mature into eggs ... which upend longstanding scientific theory, could potentially lead to ... woman,s fertility. It was long believed that women were ...
... -- A second company has issued a voluntary recall of ... lead to incorrect dosing and expose women to unintended pregnancies. ... control pill packets, sold as Norgestimate and Ethinyl Estradiol, do ... these oral contraceptives should immediately switch to another form of ...
... TAK-875, a new treatment for type 2 diabetes, improves blood ... a significantly lower risk of creating a dangerous drop in ... The results of the phase 2 randomized trial were published ... 2 diabetes is the most common form of diabetes accounting ...
Cached Medicine News:Health News:Rapid Flu Tests a Good First Step: Study 2Health News:First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen 2Health News:First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen 3Health News:First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen 4Health News:Are the Rich Really Different From You and Me? 2Health News:Are the Rich Really Different From You and Me? 3Health News:Stem Cell Finding Could Expand Women's Lifetime Supply of Eggs 2Health News:Stem Cell Finding Could Expand Women's Lifetime Supply of Eggs 3Health News:Another Batch of Birth Control Pills Recalled for Faulty Packaging 2Health News:Another Batch of Birth Control Pills Recalled for Faulty Packaging 3Health News:Diabetes drug gets patients with Type 2 diabetes on target 2
(Date:12/22/2014)... , Dec. 22, 2014 Research and ... the addition of the "Investment Analysis of ... to their offering. ... in the US medical device sector identifies the ... and venture capital investments, and mergers and acquisitions. ...
(Date:12/22/2014)... 22, 2014  Mark Farrah Associates (MFA), ... summary of the 2015 marketplace exchange projections and ... According to a recent ASPE (Office ... Department of Health and Human Services) report, an ... medical plans through the Marketplace as of October ...
(Date:12/19/2014)... the Friday, December 19 edition of USA ... (HIT) features Konica Minolta, the company announced today. The supplement will ... healthcare organizations. In addition to the print section ... New York , Chicago , ... Minneapolis and San Francisco , ...
Breaking Medicine Technology:Investment Analysis of the US Medical Device Sector 2Insights into the Marketplace and Individual Market Growth 2USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2
... Oct. 10, 2011 The Prostate Conditions Education ... men,s health and a leader in prostate cancer screening ... recommendations from the U.S. Preventative Services Task Force (USPSTF). ... for prostate cancer. PCEC believes that ...
... Today, Roche announced that Harsukh Parmar, ... of Translational and Experimental Medicine (TM) for the Inflammation ... will drive the strategy and implementation of early clinical ... in delivering innovative, first-in-class or best-in-class compounds to the ...
Cached Medicine Technology:Prostate Conditions Education Council Opposes U.S. Preventative Services Task Force Recommendation 2Prostate Conditions Education Council Opposes U.S. Preventative Services Task Force Recommendation 3Harsukh Parmar Joins Roche as Head of Translational and Experimental Medicine - Inflammation 2Harsukh Parmar Joins Roche as Head of Translational and Experimental Medicine - Inflammation 3
... The FR-120F, Fujinon's new fiberoptic Naso-Pharyngo-Laryngoscope ... and patient comfort. The latest in ... an increased light guide, and a wide ... very impressive 3.3mm distal tip diameter. ...
... Tip Laryngoscopes are the most ... The articulating tip aids during ... improved view of epiglottis. Available ... styles. We guarantee your complete ...
German Style MacIntosh Fiber Optic Blade Laryngoscopes...
CCR Medical fiberoptic green system laryngoscope handles., ,OUTSTANDING PERFORMANCE, QUALITY, AND PRICING MAKE OUR FIBEROPTIC SELECTION MOST ECONOMICAL....
Medicine Products: