Navigation Links
How do happiness and sadness circuits contribute to bipolar disorder?
Date:1/14/2013

Philadelphia, PA, January 14, 2013 Bipolar disorder is a severe mood disorder characterized by unpredictable and dramatic mood swings between the highs of mania and lows of depression. These mood episodes occur among periods of 'normal mood', termed euthymia.

Prior research has clearly shown that brain emotion circuitry is dysregulated in individuals diagnosed with bipolar disorder. It is thought that these disturbances impair one's ability to control emotion and contribute to mood episodes.

Continuing this line of research, the January 15th issue of Biological Psychiatry reports the results of a study conducted by scientists from Indiana University School of Medicine. These investigators used functional magnetic resonance imaging (fMRI) to investigate which areas of the brain showed abnormal activation while patients in different mood phases of bipolar disorder tried to control their response to emotional and non-emotional material.

This allowed them to analyze brain activation patterns based on patient mood (manic, depressed, or euthymic) and stimuli type (emotion versus no emotion and happy versus sad). Because medication effects on brain activation have been observed in some studies, the researchers recruited only unmedicated volunteers.

They found that bipolar depressed patients abnormally activated brain areas when they had to withhold responses to sad faces. Manic patients, on the other hand, had abnormal activation regardless of whether they were trying to withhold response to sad faces, happy faces or non-emotional material. Even the euthymic bipolar subjects showed abnormal activation of cortical areas of the brain while withholding responses to emotional faces.

These findings suggest that distinct circuit dysfunctions may contribute to different features of emotion dysregulation in bipolar disorder.

Professor and senior author Dr. Amit Anand said, "This study provides important information regarding brain areas that may be important in controlling response to emotional material and the functional abnormalities in these areas in mood disorders."

"It is interesting that subtly different circuits distinguish symptomatic and non-symptomatic patients with bipolar disorder when they are suppressing their happy and sad reactions," commented Dr. John Krystal, Editor of Biological Psychiatry. "These findings may have implications for the refinement of circuit-based treatments for bipolar disorder including neurostimulation and psychotherapy."


'/>"/>
Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related medicine news :

1. Travel and Other Adventures Can Boost Happiness
2. Money Really Cant Buy Happiness, Study Finds
3. United Nations Adopts International Day of Happiness
4. Childhood Friendships May Be Key to Adult Happiness
5. Study finds gene that predicts happiness in women
6. New study examines how health affects happiness
7. Fidelity Investments Brings the Happiness of the Holidays to Five Educational First Steps Assisted Centers
8. Greg Reid of Napoleon Hill Foundation Makes a Special World Premier Announcement of His Latest Project (The Secret of Happiness) on the “Your Do Over” Podcast on iTunes
9. Simple mathematical computations underlie brain circuits
10. Songbirds shed light on brain circuits and learning
11. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2017)... ... April 27, 2017 , ... Healthcare companies are trying to ... rapidly reject an outdated healthcare executive resume. , “If you’re a healthcare executive open ... resume and wondering if it’s as ready as you are for a new job ...
(Date:4/27/2017)... (PRWEB) , ... April 27, 2017 , ... ... named the 2017 North American CAREGiverSM of the Year for her extraordinary compassion ... one of its 60,000 North American professional caregivers for the prestigious award each ...
(Date:4/27/2017)... ... 27, 2017 , ... Offering the purest product of its kind, Swissx Labs ... more potent than the market has seen before. Swissx uses proprietary strains of hemp ... patented chromatography process for extraction, to produce its CBD oil--maximizing its benefits for health ...
(Date:4/26/2017)... ... April 26, 2017 , ... Jump Technologies, Inc., ... announced it has completed a round of funding to accelerate its growth strategies. ... Black Granite Capital is a growth equity firm focused on investments in healthcare ...
(Date:4/26/2017)... , ... April 26, 2017 ... ... is thrilled to announce the ATA 2017 President’s Awards recipients, comprised of ... demonstrated superior healthcare delivery. , The ATA 2017 President’s Awards recognize ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... April 20, 2017  Zimmer Biomet Holdings, Inc. (NYSE ... today announced that it will be participating in the ... the InterContinental Hotel in Boston, Massachusetts ... present at 11:20 a.m. Eastern Time. A ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com .  ...
(Date:4/20/2017)... 2017   ZappRx, Inc ., a digital health company ... today announced it closed $25 million in Series B funding ... based in Seattle that is part ... The Series B round included participation from SR One ... GV (formerly Google Ventures). As part of the ...
(Date:4/20/2017)... 20, 2017 Research and Markets has ... Manufacturing Services Market Analysis By Service (Manufacturing, Research), By Country, ... - 2025" report to their offering. ... The Latin American pharmaceutical contract manufacturing ... 2025 Low drug registration cost in Latin American ...
Breaking Medicine Technology: