Navigation Links
How do cells tell time? Scientists develop single-cell imaging to watch the cell clock
Date:11/13/2012

COLUMBUS, Ohio A new way to visualize single-cell activity in living zebrafish embryos has allowed scientists to clarify how cells line up in the right place at the right time to receive signals about the next phase of their life.

Scientists developed the imaging tool in single living cells by fusing a protein defining the cells' cyclical behavior to a yellow fluorescent protein that allows for visualization. Zebrafish embryos are already transparent, but with this closer microscopic look at the earliest stages of life, the researchers have answered two long-standing questions about how cells cooperate to form embryonic segments that later become muscle and vertebrae.

Though these scientists are looking at the molecular "clock" that defines the timing of embryonic segmentation, the findings increase understanding of cyclical behaviors in all types of cells at many developmental stages including problem cells that cause cancer and other diseases. Understanding how to manipulate these clocks or the signals that control them could lead to new ways to treat certain human conditions, researchers say.

Embryonic cells go through oscillating cycles of high and low signal reception in the process of making segmented tissue, and gene activation by the groups of cells must remain synchronized for the segments to form properly. One of a handful of powerful messaging systems in all vertebrates is called the Notch signaling pathway, and its precise role in this oscillation and synchronization has been a mystery until now.

In this study, the researchers confirmed that the cells must receive the Notch signal to maintain synchronization with nearby cells and form segments that will become tissue, but the cells can activate their genes in oscillating patterns with or without the signal.

"For the first time, this nails it," said Sharon Amacher, professor of molecular genetics at Ohio State University and lead author of the study.
'/>"/>

Contact: Sharon Amacher
Amacher.6@osu.edu
614-292-8084
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. First trial in humans of minicells: A completely new way of delivering anti-cancer drugs
2. New cells found that could help save peoples sight
3. Spread of human melanoma cells in mice correlates with clinical outcomes in patients
4. Two Years On, Stem Cells Still Healing Damaged Hearts
5. Stem Cells From Donor May Help Heal Heart
6. How bacteria talk to each other and our cells
7. Therapy with bone marrow-derived stem cells does not improve short-term recovery after heart attack
8. Scientists find Achilles’ heel of cancer cells
9. Vijay Tiwari awarded prestigious grant to study how cancer cells transform to become invasive
10. Stem cells show promise for treating infertility in cancer patients
11. A protein’s role in helping cells repair DNA damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... (PRWEB) April 21, 2015 Dr. Zain Kadri, ... released an interesting infographic that takes a close look at ... The new infographic, which appears on both Dr. Kadri’s website ... of Plastic Surgery in the Age of the Selfie.” According ... Beverly Hills to a variety of A-list patients, the ...
(Date:4/21/2015)... Spring and summer are popular seasons to ... for the holidays or simply taking vacations. Deciding what ... can be a difficult choice. Pet-friendly accommodations are gaining ... becoming a more common option. Royal Flush Havanese ... pet-friendly accommodations a positive experience. , 1.) Firstly, it ...
(Date:4/20/2015)... EDINBURGH, Scotland (PRWEB) April 21, 2015 When ... fatigue syndrome (CFS), she felt as if nothing could ... Health Service estimates that 250,000 U.K. citizens are currently living ... to take action. Her new book, “ Living a Life ... Mind, Body, Home, and Environment. Create a Happier, Healthier Life ...
(Date:4/20/2015)... 21, 2015 Is it possible to create ... relevant to the local needs of the providers, payers and ... was embraced over the past year by the Hutchinson Institute ... Cancer Research Center in Seattle, Washington. , In a new ... The American Journal of Managed Care, HICOR Director Scott ...
(Date:4/20/2015)... CT (PRWEB) April 20, 2015 Global ... Lyme” Gala, held last Saturday at the Hyatt Regency ... a cure for Lyme and other debilitating tick-borne diseases. ... volunteers, donors, friends and families who made this year’s ... “Their dedication to advancing research and education initiatives to ...
Breaking Medicine News(10 mins):Health News:Beverly Hills Plastic Surgery Expert Dr. Zain Kadri Releases Thought-Provoking New Infographic 2Health News:Royal Flush Havanese Announces 5 Tips for a Successful Stay in Pet-Friendly Accommodations 2Health News:Royal Flush Havanese Announces 5 Tips for a Successful Stay in Pet-Friendly Accommodations 3Health News:Royal Flush Havanese Announces 5 Tips for a Successful Stay in Pet-Friendly Accommodations 4Health News:New book by Faith Canter offers guide to banishing toxins 2Health News:Creating Value Metrics in Cancer Care From the Bottom Up 2Health News:Creating Value Metrics in Cancer Care From the Bottom Up 3Health News:Global Lyme Alliance's “Time for Lyme” Gala Raises Over $850,000 for Tick-Borne Disease Research 2Health News:Global Lyme Alliance's “Time for Lyme” Gala Raises Over $850,000 for Tick-Borne Disease Research 3
... study finds differences in screening account for more than ... and nearly 20 percent of colorectal cancer mortality between ... reflect differences in treatment account for additional 35% of ... study, appearing early online in Cancer Epidemiology Biomarkers ...
... HealthDay Reporter , WEDNESDAY, May 2 (HealthDay News) -- Consuming ... disease, new research suggests. The finding stems from work ... 65. All underwent blood tests to assess levels of a ... dietary breakdown dating back more than a year. "Past ...
... disease (CVD) prevention guidelines have been overhauled to ... that awards greater weight than ever before to ... The "European Guidelines on Cardiovascular Disease Prevention in ... the EuroPRevent2012 meeting in Dublin, Ireland. "In ...
... CT examinations are unnecessary for emergency department (ED) patients who ... "ground-level fall", unless the patient has a condition that predisposes ... The study, conducted at Grady Memorial Hospital by researchers from ... University School of Medicine in Atlanta, found that out of ...
... May 3, 2012, New York, NYThe United States spends more ... not provide "notably superior" care, according to a new study ... person in 2009 on health care services, while other countries ... and two-thirds (Norway and Switzerland) as much. While the U.S. ...
... 40-49 diagnosed with breast cancer on screening mammography report no family ... Elizabeth Wende Breast Care, LLC in Rochester, NY of all breast ... 373 cancers (61%) were found in women, aged 40-49 with no ... patients did have a prior personal history of breast cancer or ...
Cached Medicine News:Health News:Study says screening accounts for much of black/white disparity in colorectal cancer 2Health News:Eating More Foods Rich in Omega-3s May Lower Alzheimer's Risk: Study 2Health News:Eating More Foods Rich in Omega-3s May Lower Alzheimer's Risk: Study 3Health News:New guidelines deliver concise messages for implementing cardiovascular prevention 2Health News:New guidelines deliver concise messages for implementing cardiovascular prevention 3Health News:New guidelines deliver concise messages for implementing cardiovascular prevention 4Health News:New guidelines deliver concise messages for implementing cardiovascular prevention 5Health News:Simple assault and ground level fall do not require cervical spine CT 2Health News:US spends far more for health care than 12 industrialized nations, but quality varies 2Health News:US spends far more for health care than 12 industrialized nations, but quality varies 3Health News:US spends far more for health care than 12 industrialized nations, but quality varies 4
(Date:4/20/2015)... --  Precision Image Analysis (PIA) is sponsoring a ... cardiovascular imaging and post-processing. Scott D. Flamm , ... Cardiovascular Magnetic Resonance (SCMR) will be presenting this ... by providing broader access to Cardiac MRI (CMR). ... understand appropriate use of CMR, the strengths of CMR ...
(Date:4/20/2015)... FRANCISCO , April 20, 2015  SillaJen, ... the development of oncolytic immunotherapy products for cancer, ... research at the Annual Meeting of the American ... of a murine adapted version of its lead ... Pexa-Vec is an oncolytic immunotherapy designed to ...
(Date:4/20/2015)... 2015 The global orthopedic braces ... concerned global with analysis and forecast of revenue. This ... estimated to reach $4,918.7 million by 2019, at a ... Browse through the TOC of global orthopedic braces & ... industry trends and segments, with help of various tables ...
Breaking Medicine Technology:Educational Webinar Teaches Improved Patient Management Through Broader Access to Cardiac MRI 2SillaJen Presents Data Demonstrating Pexa-Vec Synergy with Angiogenesis Inhibitors: A Collaboration with University of California, San Francisco 2SillaJen Presents Data Demonstrating Pexa-Vec Synergy with Angiogenesis Inhibitors: A Collaboration with University of California, San Francisco 3Global Orthopedic Braces & Support System Market is Expected to Reach $4,918.7 Million by 2019, at a CAGR of 4.4% from 2014 to 2019 2Global Orthopedic Braces & Support System Market is Expected to Reach $4,918.7 Million by 2019, at a CAGR of 4.4% from 2014 to 2019 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: