Navigation Links
How did glycine significantly decrease liver injury?
Date:10/31/2008

The nonessential amino acid glycine has been shown to be anti-inflammatory in several animal injury models. Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin in rat or other animals and improved graft survival after liver transplantation. The influence of dietary glycine on oxidant-induced or cholestatic liver injury was not known.

A research article to be published on October 21, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Thurman from the University of North Carolina used a dietary and cholestatic model thru BDL in rats to address this question. They could demonstrate that hepatic injury due to BDL is significantly reduced by dietary glycine in rats. Moreover, the data indicated that glycine decreases liver injury under the conditions of experimental cholestasis thru a direct effect on hepatocytes. Surprisingly, Kupffer cells did not appear to play a major role in the pathological changes caused by cholestasis.

It is best known that Kupffer cells, the resident macrophages of the liver, are involved in several disease states, such as endotoxin shock, alcoholic liver diseases, and other toxicant-induced liver injury by releasing eicosanoids, inflammatory cytokines, and free radical species. Furthermore, in previous studies of the research team, a glycine-dependent chloride channel on the cell membrane of Kupffer cells and other macrophages that influence the activation process of these cells could be detected. But in the actual used cholestatic model no significant influence of this cell line on liver injury could be detected.


'/>"/>

Contact: Lin-Lin Xiao
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. U of T research finds glycine could be key to REM Sleep Behavior Disorder
2. New intranasal influenza vaccine triggers robust immunity with significantly less antigen
3. Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust Immunity Using Significantly Less Antigen
4. Expert Says Conseco Trust May Significantly Alter The Senior Health Care Market
5. New EPA Lead Standard Significantly Improved to Protect Kids Health
6. Estimate of Annual HIV Incidence Increases Significantly; New Estimate Will Show Need For a National AIDS Strategy
7. On-X Life Technologies Significantly Reduces Study Management Costs with TEMPO from Clinipace
8. New study shows calcium significantly improves childrens bone health
9. Study: Global Business Performance Significantly Improved Through Project Management
10. Hibernation-on-demand drug significantly improves survival after extreme blood loss
11. Combining radiation and surgery significantly improves survival for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... ... and financial planning services to families and business owners in the greater Kansas ... supporting children with developmental disabilities. , The Lakemary Center is a comprehensive educational ...
(Date:1/18/2017)... ... January 18, 2017 , ... The Hear ... aid project with the donation of cochlear implants. In February 2017, the first ... thus a fair chance of leading an independent life. This engagement builds on ...
(Date:1/17/2017)... ... January 17, 2017 , ... Anesthesia Progress – Everyone wants less ... best drug option for each patient. Dentists have several general anesthesia alternatives and finding ... Researchers from the Tokyo Dental College in Tokyo, Japan wanted to find out which ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... supplement, Healthful-Flex. , The company, owned and operated by Ed Stroup, was ... a reasonable price with the highest level of customer service. Healthful Balance products ...
(Date:1/17/2017)... ... 17, 2017 , ... Achieve TMS West, with multiple locations ... office in San Clemente, California this month. Achieve TMS West is the largest ... individuals struggling with major depression. Depression impacts over 15 million adults in the ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... In China , we say Health is ... China,s Healthy Strategy originates. 2016 is ... and Social Development of the People,s Republic of ... council of the People,s Republic of China ... plan, identifying medical devices as one of the main breakthrough ...
(Date:1/18/2017)... 2017 Ximbio, a non-profit online one-stop-shop ... has opened its first North American headquarters in Kendall Square, ... ... Ximbio following its launch in October 2014 as a business ... commercialization arm of the foundation Cancer Research UK. ...
(Date:1/18/2017)... Regulatory Authority Chinese Food and Drug Administration CSL ... Flanders Institute Food and Drug Administration FORT ... Glaxo Smith Klein GlaxoWellcome Global ... Japan Immune Targeting Systems Indian Association ... oxford Johnson & Johnson Krka Pharmaceuticals ...
Breaking Medicine Technology: