Navigation Links
How did glycine significantly decrease liver injury?
Date:10/31/2008

The nonessential amino acid glycine has been shown to be anti-inflammatory in several animal injury models. Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin in rat or other animals and improved graft survival after liver transplantation. The influence of dietary glycine on oxidant-induced or cholestatic liver injury was not known.

A research article to be published on October 21, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Thurman from the University of North Carolina used a dietary and cholestatic model thru BDL in rats to address this question. They could demonstrate that hepatic injury due to BDL is significantly reduced by dietary glycine in rats. Moreover, the data indicated that glycine decreases liver injury under the conditions of experimental cholestasis thru a direct effect on hepatocytes. Surprisingly, Kupffer cells did not appear to play a major role in the pathological changes caused by cholestasis.

It is best known that Kupffer cells, the resident macrophages of the liver, are involved in several disease states, such as endotoxin shock, alcoholic liver diseases, and other toxicant-induced liver injury by releasing eicosanoids, inflammatory cytokines, and free radical species. Furthermore, in previous studies of the research team, a glycine-dependent chloride channel on the cell membrane of Kupffer cells and other macrophages that influence the activation process of these cells could be detected. But in the actual used cholestatic model no significant influence of this cell line on liver injury could be detected.


'/>"/>

Contact: Lin-Lin Xiao
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. U of T research finds glycine could be key to REM Sleep Behavior Disorder
2. New intranasal influenza vaccine triggers robust immunity with significantly less antigen
3. Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust Immunity Using Significantly Less Antigen
4. Expert Says Conseco Trust May Significantly Alter The Senior Health Care Market
5. New EPA Lead Standard Significantly Improved to Protect Kids Health
6. Estimate of Annual HIV Incidence Increases Significantly; New Estimate Will Show Need For a National AIDS Strategy
7. On-X Life Technologies Significantly Reduces Study Management Costs with TEMPO from Clinipace
8. New study shows calcium significantly improves childrens bone health
9. Study: Global Business Performance Significantly Improved Through Project Management
10. Hibernation-on-demand drug significantly improves survival after extreme blood loss
11. Combining radiation and surgery significantly improves survival for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/18/2017)... Sherman Oaks, CA (PRWEB) , ... July 18, 2017 , ... ... and Ph.D. scientist extracted cannabis oils, announced today that at the WORLDZ Summit, taking ... Ryan will be speaking on the therapeutic benefits of medical cannabis for both pediatric ...
(Date:7/18/2017)... ... July 18, 2017 , ... ClinicalTrials.gov and the ... You Need to Consider?, **An FDAnews Webinar**, Aug. 2, 2017 — 1:30 p.m. ... “Final Rule for Clinical Trials Registration and Results Information,” is a head-scratcher. After ...
(Date:7/18/2017)... Indio, California (PRWEB) , ... July 18, 2017 ... ... providers working on a lien basis, partners with the best medical professionals who ... Liens pre-screens and pre-approves each medical professional in their network, ensuring that each ...
(Date:7/18/2017)... ... July 18, 2017 , ... An inventor from Seattle, Wash., has developed ... to clean, scrub and moisturize the back and other hard-to-reach areas of the body. ... movement in my upper body, particularly my shoulders. I found it difficult to reach ...
(Date:7/18/2017)... ... 19, 2017 , ... USHEALTH Group, Inc. has been announced ... prestigious CEO World Awards®. The coveted annual CEO World Awards program encompasses ... case studies, corporate social responsibility, and milestones from every major industry in the ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... July 11, 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company focused on the development of oral drug ... Drug Administration (FDA) has agreed to schedule an End-of-Phase ... IIb trial of its oral insulin capsule ORMD-0801 in ... trial met primary and secondary endpoints by indicating a ...
(Date:7/10/2017)...  BDI Group subsidiary Pathway Purchasing Network, a ... serving specialty pharmacies, home infusion companies and physician ... value-added member programs designed to help organizations gain ... improve access and affordability for patients who rely ... Pathway has worked with ...
(Date:7/6/2017)... -- ThriveRx, the nutrition division of Diplomat Specialty Infusion Group, is celebrating ... support. To celebrate its anniversary, ThriveRx recently launched a redesigned ... look with improved organization to create the best user experience for consumers ... ... "We,ve made several great strides throughout ...
Breaking Medicine Technology: