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How cells running on empty trigger fuel recycling
Date:12/23/2010

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"The worm experiments show that the connection between AMPK, ULK1 and autophagy is conserved across evolution and not just a recent adaptation specific to mammals," says Egan. "Processes fundamental to life, like energy regulation, metabolism and autophagy, share components across human, mouse, worm, and yeast species."

But if you aren't an evolutionary biologist, you still have a personal stake in AMPK signaling if you: exercise regularly, feel good about drinking red wine, take diabetes meds, and/or starve yourself in hopes of a long lifeall of which reportedly stimulate AMPK signals.

Add to that the possibility that AMPK may have anti-tumor activity and it is no wonder that pharmaceutical companies are keenly interested in what proteins AMPK "talks to" and how drugs that stimulate that conversation work.


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Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

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