Navigation Links
How cells know when it's time to eat themselves
Date:1/17/2013

Researchers at the University of California, San Diego School of Medicine have identified a molecular mechanism regulating autophagy, a fundamental stress response used by cells to help ensure their survival in adverse conditions.

The findings are published online in the January 17 issue of Cell.

Senior author Kun-Liang Guan, PhD, a professor of pharmacology at UC San Diego Moores Cancer Center, and colleagues report that an enzyme called AMPK, typically involved in sensing and modulating energy use in cells, also regulates autophagic enzymes.

Autophagy, which derives from the Greek words for "self" and "eat," is triggered to protect cells when times are tough, such as when cells are starved for nutrients, infected or suffering from damaged organelles, such as ribosomes and mitochondria. Much like the human body in freezing conditions will reduce operations in extremities to preserve core temperatures and organ functions, cellular autophagy involves the degradation and synthesis of some internal cellular elements to ensure survival of the whole.

The scientists found that AMPK regulates different complexes of an enzyme class called Vps34 kinase in different ways. Some Vps34 enzymes are involved in normal cellular vesicle trafficking the vital movement of molecules inside a cell. Other Vps34 complexes are involved in autophagy. Guan and colleagues say AMPK inhibits some non-autophagy enzymes, but activates autophagous ones.

The study more fully illuminates a process essential to healthy cell function and survival. "Autophagy is an important way for cells to clear damaged parts that could be harmful to them and to digest parts for nutrients when cells are experiencing starvation conditions," Guan said.

More broadly, he noted that "defects in autophagy have been associated with human disease, such as cancer and neurodegenerative disorders." Failure of normal autophagy has also been associated with accumulated cell damage and aging.


'/>"/>
Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. New drug prevents spread of human prostate cancer cells
2. Tiny hitchhikers attack cancer cells
3. To prevent leukemias dreaded return, go for the stem cells
4. Scientists identify major source of cells defense against oxidative stress
5. Therapy exploits addiction of leukemia cells
6. IBN discovers human neural stem cells with tumor targeting ability
7. Leukaemia cells have a remembrance of things past
8. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
9. Research yields new clues to how brain cancer cells migrate and invade
10. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
11. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How cells know when it's time to eat themselves
(Date:7/21/2017)... ... 21, 2017 , ... Bernard R. Bach, Jr., MD, orthopaedic surgeon at Rush ... Society of Sports Medicine (AOSSM) , received the 2017 Robert E. Leach Sports Medicine ... Canada. This prestigious award is given annually to honor those who have made a ...
(Date:7/21/2017)... ... July 21, 2017 , ... The ... from the C. R. Bard Foundation, Inc. to support the music ... a service available through the nonprofit home care agency. Using evidence-based methods, professionally ...
(Date:7/21/2017)... ... 21, 2017 , ... Sharon Kleyne is proud of the ... research center at Bio-Logic Aqua Research® Water Life Science®, has been released in ... sufferers of blindness. “We think that Nature’s Tears® EyeMist® will contribute to eliminating ...
(Date:7/21/2017)... TORONTO, ONTARIO, CANADA (PRWEB) , ... July 21, ... ... repair a torn anterior cruciate ligament (ACL) offer patients improved quality of life ... Orthopaedic Society for Sports Medicine’s Annual Meeting in Toronto, Ontario, Canada. The ...
(Date:7/20/2017)... ... ... ChenMed , a leading provider of value-based care for seniors, today announced ... Chief Medical Officer. Dr. McCarter, formerly Associate Professor of Family Medicine at the ... for the UVA Health System, brings 30 years of highly relevant experience to his ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... -- RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides ... San Jose for hi-tech, pharmaceutical and biomedical ... with its Fremont Innovation District, is excited to strategically partner ... to the hundreds of biotech, pharma and biomed companies throughout ...
(Date:7/11/2017)... 2017  Bayer has awarded grants totaling more than $2 ... its prestigious Bayer Hemophilia Awards Program (BHAP). Four U.S. clinicians ... and Uniformed Services University of the Health Sciences ... Grant recipients were announced last night during a reception at ... Berlin, Germany . ...
(Date:7/10/2017)... 10, 2017  US medical equipment and supply demand ... to Medical Equipment & Supplies: United States ... Reports. Continued increases in demand for medical services – ... population and supported by gains in disposable personal income ... New product introductions will also drive sales as providers ...
Breaking Medicine Technology: